|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Adjunctive aripiprazole for antipsychotic-related hyperprolactinaemia in patients with first-episode schizophrenia:a metaanalysis显示文摘Background Hyperprolactinaemia is a common antipsychotic(AP)-induced adverse effect,particularly in female patients.Aims This meta-analysis examined the efficacy and safety of adjunctive aripiprazole in preventing AP-related hyperprolactinaemia in patients with first-episode schizophrenia.Methods PubMed,PsycINFO,EMBASE,Cochrane Library,WanFang and China Journal Net databases were searched to identify eligible randomised controlled trials(RCTs).Primary outcomes were the reductions of serum prolactin level and prolactin-related symptoms.Data were independently extracted by two reviewers and analysed using RevMan(V.5.3).Weighted/standardised mean differences(WMDs/SMDs)±95%Cis were reported.Results In the five RCTs(n=400),the adjunctive aripiprazole(n=197)and the control groups(n=203)with a mean of 11.2 weeks of treatment duration were compared.The aripiprazole group had a significantly lower endpoint serum prolactin level in all patients(five RCTs,n=385;WMD:-50.43 ng/mL(95%Cl:-75.05 to-25.81),p<0.00001;l2=99%),female patients(two RCTs,n=186;WMD:-22.58 ng/mL(95%Cl:-25.67 to-19.49),p<0.00001;l2=0%)and male patients(two RCTs,n=127;WMD:-68.80 ng/mL(95%Cl:-100.11 to-37.49),p<0.0001).In the sensitivity analysis for the endpoint serum prolactin level in all patients,the findings remained significant(p<0.00001;l2=96%).The aripiprazole group was s叩erior to the control group in improving negative symptoms as assessed by the Positive and Negative Syndrome Scale(three RCTs,n=213;SMD:-0.51(95%Cl:-0.79 to-0.24),p=0.0002;l2=0%).Adverse effects and discontinuation rates were similar between the two groups.Conclusions Adjunctive aripiprazole appears to be associated with reduced AP-induced hyperprolactinaemia and improved prolactin-related symptoms in first-episode schizophrenia.Further studies with large sample sizes are needed to confirm these findings. | Wei Zheng Dong-Bin Cai Xin-Hu Yang Wei Zheng Gabor S Ungvari Chee H Ng Zhan-Ming Shi Mei-Ling Hu Yu-Ping Ning Yu-Tao Xiang | 2019 | General Psychiatry2019，32，5： | 4 |
| 2 | Adjunctive Peony-Glycyrrhiza decoction for antipsychotic-induced hyperprolactinaemia:a meta-analysis of randomised controlled trials显示文摘Background Hyperprolactinaemia is a common adverse effect of antipsychotics(APs). The results of PeonyGlycyrrhiza decoction(PGD) as a potentially useful adjunctive treatment for hyperprolactinaemia are inconsistent.Aim This meta-analysis of randomised controlled trials(RCTs) examined the efficacy and safety of adjunctive PGD therapy for AP-induced hyperprolactinaemia.Methods English(PubMed, Embase, Cochrane Library,PsycINFO) and Chinese(Chinese National Knowledge Infrastructure, Wanfang Data) databases were systematically searched up to 10 June 2018. The inclusion criteria were based on PIC0 S一/^rticipants: adult patients with schizophrenia; Aitervention: PGD plus APs; Cbmparison: APs plus placebo or AP monotherapy;(Xjtcomes: efficacy and safety; Study design: RCTs. The weighted mean difference(WMD) and risk ratio(RR) along with their 95% CIs were calculated using Review Manager(RevMan) V.5.3 software.Results Five RCTs(n=450) were included and analysed.Two RCTs(n=140) were double-blind and four RCTs(n=409) reported ‘random' assignment with specific description. The PGD group showed a significantly lower serum prolactin level at endpoint than the control group(n=380, WMD:-32.69 ng/mL(95% Cl-41.66 to 23.72),/X0.00001, ^=97%). Similarly, the superiority of PGD over the control groups was also found in the improvement of hyperprolactinaemia-related symptoms. No difference was found in the improvement of psychiatric symptoms assessed by the Positive and Negative Syndrome Scale(n=403,WMD:-0.62(95% Cl-2.38 to 1.15), p=0.49, ^=0%). There were similar rates of all-cause discontinuation(n=330, RR0.93(95% Ci 0.63 to 1.37),/t=0.71, ^=0%) and adverse drug reactions between the two groups. According to the Grading of Recommendations Assessment, Development and Evaluation approach, the level of evidence of primary and secondary outcomes ranged from ‘very low'(14.3%),‘low'(42.8%),‘moderate'(14.3%),to ‘high,(28.6%>.Conclusions Current evidence supports the adjunctive use of PGD to suppress elevated prolactin and improve prolactininduced symptoms without significant adverse events in adult patients with AP-induced hyperprolactinaemia. Highquality RCTs with longer duration are needed to confirm these findings.Trial registration number 42016037017. | Wei Zheng Dong-Bin Cai Hai-Yan Li Yu-Jie Wu Chee H Ng Gabor S Ungvari Shan-Shan Xie Zhan-Ming Shi Xiao-Min Zhu Yu-Ping Ning Yu-Tao Xiang | 2018 | General Psychiatry2018，31，4： | 3 |
| 3 | Antipsychotic Medications in Major Depression and the Association with Treatment Satisfaction and Quality of Life: Findings of Three National Surveys on Use of Psychotropics in China Between 2002 and 2012显示文摘 | Yu-Xi Wang Yu-Tao Xiang Yun-Ai Su Qian Li Liang Shu Chee H Ng Gabor S Ungvari Helen FK Chiu Yu-Ping Nin Gao-Hua Wang Pei-Shen Bai Tao Li Li-Zhong Sun Jian-Guo Shi Xian-Sheng Chen Qi-Yi Mei Ke-Qing Li Xin Yu Tian-Mei Si | 2015 | Chinese Medical Journal2015，，14： | 2 |
| 4 | Obesity in Malaysia显示文摘 | Ismail MN Chee SS Nawawi H | 2002 | Obesity Reviews2002，3，： | 1 |
| 5 | Label-free direct detection of MiRNAs with silicon nanowire biosensors 显示文摘 | Zhang G J Chua J H Chee R E | 2009 | Biosens Bioelectron2009，24，8： | 1 |
| 6 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 7 | On maximum-likelihood SINR estimation of MPSK in a mul- tiuser fading channel显示文摘 | SOROOSHYARI Siamak TAN Chee Wei POOR H Vincent | 2010 | IEEE Transactions on Vehicular Tech- nology2010，59，8： | 1 |
| 8 | Rubber diseases and their control显示文摘 | Chee K H | 1990 | Review of Plant Pathology1990，69，7： | 1 |
| 9 | Wideband commu-nication for implantable and wearable systems显示文摘 | YUCE M R CHEE K H SUNG C M | 2009 | IEEE Mi-crowave Theory and Techniques2009，，57： | 1 |
| 10 | Present status of rubber diseases and their control显示文摘 | Chee K H | 1990 | Review of Plant Pathology1990，69，7： | 1 |
| 11 | Immunology,microbiology,and virology following placement of Nobel Perfect scalloped dental implants:analysis of a case series显示文摘 | Nowzari H Yi K Chee W | 2008 | Clin Implant Dent Relat Res2008，10，3： | 1 |
| 12 | Label-free electrical detec- tion of cardiac biomarker with complementary metal-oxide semi- conductor compatible silicon nanowire sensor arrays 显示文摘 | Chua J H Chee RE Agarwal A | 2009 | Anal Chem2009，81，15： | 1 |
| 13 | Tracking with vir- tual slides: a tool to study diagnostic error in histopathol- ogy显示文摘 | Darren T Chee H L Derek M | 2009 | Histopathology2009，55，1： | 1 |
| 14 | Evaluation of microbial trans glutaminase and ribose cross-linked soy protein isolate based mi crocapsules containing fish oil显示文摘 | Chee Y G Lai H C Azhar M I | 2008 | Innovative Food Science and Emerging Technologies2008，，9： | 1 |
| 15 | Detection of Plasmodiophora brassicae by using polymerase chain reaction显示文摘 | CHEE H Y KIM W G CHO W D | 1998 | Korean Journal of Plant Pathol1998，14，6： | 1 |
| 16 | Aspirin and other antiplatelet drugs in the prevention of venous thromboembolism 显示文摘 | Watson H Chee Y | 2008 | Blood Reviews2008，22，2： | 1 |
| 17 | Squamous cell carcinoma of the temporal bone: a radiographic-pathologic correlation 显示文摘 | Gillespie M B Francis H W Chee N | 2001 | Arch Otolaryngol Head Neck Surg2001，127，7： | 1 |
| 18 | Techniques for vibration control of a flexible robot manipulator 显示文摘 | Mohamed Z Chee A K Mohd H A W I | 2006 | Robotica2006，24，4： | 1 |
| 19 | Linear size optimal q-ary constant-weight codes and constant-composition codes 显示文摘 | Chee Y M Dau S H Ling A C H Ling S | 2010 | IEEE Transactions on Information Theory2010，56，： | 1 |
| 20 | Optimization of microwave-assisted solvent extraction of polycyclic aromatic hydrocarbons in marine sediments using a microwave extraction system with high performance liquid chromatography-fluorescence detection and gas chromatography-mass spectrometry显示文摘 | Chee K K Wong M K Lee H K | 1996 | J Chromatogr A1996，723，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员