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| 1 | Cytokine and apoptosis gene polymorphisms influence the outcome of hepatitis C virus infection显示文摘BACKGROUND:Hepatitis C virus (HCV) infection is thought to be chronic and the factors leading to viral clearance or persistence are poorly understood.This study was undertaken to investigate the possibility of a significant relationship between the spontaneous clearance or the persistence of hepatitis C virus (HCV) infection and cytokine and apoptosis gene polymorphisms in Tunisian patients on hemodialysis.METHODS:Polymorphisms of the genes IL-1 (-889 IL-1α,-511 and +3954 IL-1β,IL-1Ra),IL-18 (-137 and-607),IL-12 (-1188) and Apo1/Fas (-670) were determined by PCR-RFLP,PCR-SSP and PCR-VNTR in 100 healthy blood donors and 100 patients infected with HCV and undergoing hemodialysis.The patients were classified into two groups:G1 consisted of 76 active chronic hepatitis patients (positive for HCV RNA) and G2 consisted of 24 hemodialysed patients who spontaneously eliminated the virus (negative for HCV RNA).RESULTS:The frequency of genotype association [-137GC/-607CA] IL-18 was higher in G2 (41.7%) than in G1 (15.8%) (P=0.008;OR=0.26;95% CI,0.10-0.73).We also found a higher frequency of the AA genotype of the Apo1/Fas gene in G2 (41.6%) than in G1 (17.5%) (P=0.026;OR=3.49;95% CI,1.13-10.69).Adjustment for known covariate factors (age,gender and genotype) confirmed these univariate findings and revealed that the genotype association GC-CA of the (-137 and-607) IL-18 gene and the AA genotype of the Apo1/Fas gene were associated with the clearance of HCV (P=0.041 and 0.017,respectively).CONCLUSION:The two genotypes GC-CA of the (-137 and-607) IL-18 polymorphism and the AA genotype of the Apo1/Fas gene influence the outcome of HCV infection in Tunisian patients on hemodialysis. | Leila Ksiaa Cheikhrouhou Imen Sfar Hajer Aounallah-Skhiri Houda Aouadi Salwa Jendoubi-Ayed Taieb Ben Abdallah Khaled Ayed Yousr Lakhoua-Gorgi | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 4 |
| 2 | Natural evolution of hepatitis C virus infection in hemodialysis Tunisian patients and CTLA-4 SNP's显示文摘AIM: To analyze the polymorphisms of CTLA-4 gene involved in the response against hepatitis C virus(HCV) infection.METHODS: We recruited 500 hemodialysed patients from several hemodialysis centers, all HCV-antibody positive, spread over different regions of Tunisia, as part of a national survey in 2008 conducted in the laboratory of immunology at the Charles Nicolle hospital Tunisia, classified into two groups G1(PCR+) and G2(PCR-) according to the presence or absence of viral RNA. Of these patients, 307 were followed prospectively on a viral molecular level over a period from 2002 to 2008, divided into two groups based on the persistence and viral clearance. PCR-RFLP was performed for the analysis of SNPs(+49) A/G and(+6230) G/A CTLA-4 for these 500 patients and 358 healthy controls.RESULTS: Analysis of clinical and virological charac-teristics of our cohort suggests a nosocomial infection in our hemodialysed patients with transfusion history as a primary risk factor and a predominance of genotype 1b. The haplotype analysis revealed an increase of frequencies of GG(+49)/(CT60) CTLA-4 in the entire patients group compared to controls(P = 0.0036 and OR = 1.42; 95%CI: 1.12-1.79, respectively). This haplotype is therefore associated with susceptibility to HCV infection. CONCLUSION: Our study suggests a possible role of CTLA-4 polymorphisms in the outcome of HCV infection in the Tunisian hemodialysed population. | Leila Ksiaa Cheikhrouhou Yousr Lakhoua-Gorgi Imen Sfar Salwa Jendoubi-Ayed Houda Aouadi Mouna Makhlouf Khaled Ayed Taieb Ben Abdallah | 2015 | World Journal of Gastroenterology2015，21，35： | 2 |
| 3 | A rewarding punishing coordination mechanism based on trust in a diver- gent supply chain 显示文摘 | Pezeshki Y Baboli A Cheikhrouhou N | 2013 | European Journal of Operational Re-search2013，230，1： | 1 |
| 4 | Selecting the optimal neural network architecture for predicting cotton yam hairiness 显示文摘 | Babay A Cheikhrouhou M Vermeulen B | 2005 | Journal of the Textile Institute2005，96，3： | 1 |
| 5 | Vacancy effects on the crystallographir and magnetic properties in lacunar Pr07Ba03MnO3 oxides 显示文摘 | Ellouze M Boujelben W Cheikhrouhou A | 2002 | Solid State Comm2002，124，： | 1 |
| 6 | Selecting the optimal neural network architecture for predicting cotton yarn hairiness 显示文摘 | Babay A Cheikhrouhou M Vermeulen B | 2005 | Journal of the Textile Institute2005，96，3： | 1 |
| 7 | Selecting the optimal neural network architecture for predicting cotton yarn hairiness 显示文摘 | BABAY A CHEIKHROUHOU M VERMEULEN B | 2005 | The Journal of The Textile Institute2005，96，3： | 1 |
| 8 | Review of Full Truckload Transportation Service Procurement显示文摘 | Basu R J Subramanian N Cheikhrouhou N | 2015 | Transport Re- views2015，35，5： | 1 |
| 9 | Selecting the optimal neural network architecture for predicting cotton yarn hairiness显示文摘 | BABAY A CHEIKHROUHOU M VERMEULEN B | 2005 | Journal of the Textile Institute2005，96，3： | 1 |
| 10 | Simultaneous coordination of capacity building and price decisions in a decentralized supply chain显示文摘 | Pezeshki Y Baboli A Cheikhrouhou N Modarres M Jokar blRA | 2013 | EUROPEAN JOURNAL OF OPERATIONAL RESEARCH2013，230，3： | 1 |
| 11 | Selecting the optimal neural network architecture for predicting cotton yarn hairiness显示文摘 | Babay A Cheikhrouhou M Vermeulen B | 2005 | Journal of the Textile Institute2005，96，3： | 1 |
| 12 | A decision support system assessing the trust level in supply chains based on information sharing dimensions 显示文摘 | Ayadi O Cheikhrouhou N Masmoudi F | 2013 | COM- PUTERS & INDUSTRIAL ENGINEERING2013，66，2： | 1 |
| 13 | A reward- ing-punishing coordination mechanism based on Trust in a divergent supply chain显示文摘 | Pezeshki Y Baboli A Cheikhrouhou N | 2013 | European Journal of Operation- al Research2013，230，3： | 1 |
| 14 | An EAP-EHash Authentication Method Adapted to Resource Constrained Terminals显示文摘 | Cheikhrouhou O Laurent M Abdallah A B | 2010 | Annals of Telecommunications2010，65，56： | 1 |
| 15 | Epidemiological profile of fungal keratitis in Sfax (Tunisia) 显示文摘 | Cheikhrouhou F Makni F Neji S | 2014 | J Mycol Med2014，24，4： | 1 |
| 16 | An assessment of the dimensionality of should and will service expectations 显示文摘 | Laroche M Kalamas M Cheikhrouhou S Cezard A | 2004 | ASAC2004，，1： | 1 |
| 17 | A rewarding - pun-ishing coordination mechanism based on trust in a divergent supplychain 显示文摘 | Pezeshki Y Baboli A Cheikhrouhou N A | 2013 | European Journal of Operational Research2013，230，3： | 1 |
| 18 | Epidemiological profile of fungal keratitis in Sfax(Tunisia)显示文摘 | Cheikhrouhou F Makni F Neji S | 2014 | J Mycol Med2014，24，4： | 1 |
| 19 | A decision support system assessing the trust level in supply chains based on information sharing dimensions显示文摘 | AYADI O CHEIKHROUHOU N MASMUDI F | 2013 | Journal of Computer and Industrial Engineering2013，66，2： | 1 |
| 20 | Selecting the optimal neural network architecture for predicting cotton yarn hairiness 显示文摘 | Bahay A Cheikhrouhou M Vermeulen B | 2005 | Journal of the Textile Institute2005，96，3： | 1 |
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