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| 1 | Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation显示文摘通过 ubiquitination 小径的 p53 蛋白质周转是在它的 transcriptional 活动的规定的重要机制;然而,很少通过 proteasome 独立的小径对 p53 周转被知道。消化机关扩大因素(Def ) 蛋白质为消化机关的发展是必要的。在 zebrafish, def 的功能的损失有选择地 upregulates p53 反应基因的表示,它提出至于是在 Def 和 p53 之间的关系的一个问题。我们这里报导 Def 是核仁的蛋白质并且 def 的功能的损失导致 p53 蛋白质的 upregulation,它令人惊讶地在 nucleoli 积累。我们的广泛的研究证明了 Def 能调停这个过程是的 p53 蛋白质和那的降级在 Calpain3 的活动独立于 proteasome 小径,却依赖,半胱氨酸朊酶。我们的调查结果定义调整 p53 的周转功能的一条新奇核仁的小径,它将在 organogenesis 和 tumorigenesis 推进我们 p53 的角色的理解。 | Ting Tao Hui Shi Yihong Guan Delai Huang Ye Chen David P Lane Jun Chen Jinrong Peng | 2013 | Cell Research2013，23，5： | 8 |
| 2 | Ni-induced stepwise capacity increase in Ni-poor Li-rich cathode materials for high performance lithium ion batteries显示文摘Li 富有的阴极材料为高精力的锂离子电池(解放) 被认为候选人同样有希望。在这研究,我们报导Li富有的材料的一个新系列(李[李<潜水艇class=“ a-plus-plus ”> 1/32x/3 Mn <潜水艇class=“ a-plus-plus ”> 2/3x/3 Ni <潜水艇class=“ a-plus-plus ”> x ]O 2 ( 0.09 x 0.2 ))在解放作为阴极材料与 Ni 的小数量做了,它由于李的连续激活展出了能力增加的不平常的现象直到十个周期<潜水艇class=“ a-plus-plus ”> 2 MnO <潜水艇class= a-plus-plus > 3 阶段。试验性、计算的结果显示不同于通常学习的做 Ni 的 Li 富有的阴极材料,做的 Ni 的更小的数量能提拔逐步的李 < 潜水艇 class= “ a-plus-plus ” > 2 MnO < 潜水艇 class= “ a-plus-plus ” > 获得的 3 激活增加了特定的能力和更好骑车的能力。相反,过多的 Ni 愿望在激活上李 < 潜水艇 class= “ a-plus-plus ” > 2 MnO < 潜水艇 class= “ a-plus-plus ” > 在在第一的大能力损失的 3 和结果骑车。李<潜水艇class=“ a-plus-plus ”> 1.25 Mn <潜水艇class=“ a-plus-plus ”> 0.625 Ni <潜水艇class=“ a-plus-plus ”> 0.125 O <潜水艇class=“ a-plus-plus ”>有 Ni 的一个优化内容的 2 材料高交付了上级能力 280 mAh ?瀠汯??瑳特湥?潣洭污楥??€ ????????????????????楢慬敹?????搠獩潣摩污?慮潮慰瑲捩敬?? | Delai Ye Chenghua Sun Yu Chen Kiyoshi Ozawa Denisa Hulicova-JurcakovaI Jin Zou Lianzhou Wang | 2015 | Nano Research2015，8，3： | 4 |
| 3 | Effect of rich R-TiO2 on the rate and cycle properties of Li4Ti5O12 as anode for lithium ion batteries显示文摘Li4Ti5012 (LTO) with rich R-TiO2 (17.06, 23.69, and 34.42 wt%), namely, R-TiO2@Li4Ti5O12 composites, were synthesized using the hydrothermal method and tetrabutyl titanate (TBT) as the precursor. Rietveld refinement of X-ray diffraction (XRD) results show that the proportion of Li occupying 16d sites is extraordinary low and the lattice constants of LTO and R-TiO2 change with the ritanium dioxide content. EIS measurements showed that with in creasing R-TiO2 content, both its charge transfer impedance (Rct) and lithium ion diffusion coefficient (DLi) decreased. The changes of Rct and DLi caused by the increase of titanium dioxide content have synergic-antagonistic effects on the rate and cycle properties of Li4Ti5012. The rate performance is positively related to DLi, while the cycle property is negatively correlated with Rct, indicati ng that the rate performs nee is mainly related to DLi, while Rct more significantly affects the cycle performance. LTO-RT-17.06% exhibited excellent rate properties, especially under a high current density (5.0 C, 132.5 mAh/g) and LTO-RT-34.42% showed superior long-term cycle performance (0.012% capacity loss per cycle) compared to that of LTO-RT-17.06% and LTO-RT-23.69%. | Delai Qian Yijie Gu Shuainan Guo Hongquan Liu Yunbo Chen Juan Wang Guoxuan Ma Chuan Wu | 2019 | Journal of Energy Chemistry2019，28，5： | 3 |
| 4 | Efficient Partially Asynchronous Parallel Simulation on Multicomputer Systems: Research and Practice显示文摘This paper presents partially asynchronous parallel simulation of continuous-system(PAPSoCS) and some approaches to the issues of its implementation on a multicomputer system.To guarantee the simulation results correct and speedup the simulation, the scheme for efficient PAPSoCS is proposed and the virtual topology star is constructed to match the path of message passing for solving algorithm-architecture adequation problem. Under the circumstances that messagesfrequently passed inter-processor are much shorter,typically within several 4 bytes,asynchronouscommunication mode is employed to reduce the communication ratio. Experiment results show thatasynchronous parallel simulation has much higher efficiency than its synchronous counterpart. | Chen, Delai Hong, Bo Xie, Zhiwu Weng, Shilie | 1998 | Journal of Systems Engineering and Electronics1998，9，2： | 0 |
| 5 | Experimental Evaluation of Objective Functions for Well-balanced Mapping显示文摘ExperimentalEvaluationofObjectiveFunctionsforWell-balancedMappingChenDelai;XuHong;ZhouYingandZhangDefu(DepartmentofComputerSc... | Chen Delai Xu Hong Zhou Ying and Zhang Defu(Department of Computer Science and Technology Nailing University, Naming 210093, P. R. China) | 1996 | Wuhan University Journal of Natural Sciences1996，1，Z1： | 0 |
| 6 | A Parallel Multicomputer Simulation System显示文摘AParallelMulticomputerSimulationSystem￥ChenDelai;WangChen;ZhouYing&ZhangDefu(DepartmentofComputerScienceandTechnologyNamingUn... | Chen Delai Wang Chen Zhou Ying & Zhang Defu(Department of Computer Science and TechnologyNaming University, Naming 210093, P.R. China) | 1995 | Journal of Systems Engineering and Electronics1995，6，3： | 0 |
| 7 | Capn3 depletion causes Chk1 and Wee1 accumulation and disrupts synchronization of cell cycle reentry during liver regeneration after partial hepatectomy显示文摘Recovery of liver mass to a healthy liver donor by compensatory regeneration after partial hepatectomy(PH)is a prerequisite for liver transplantation.Synchronized cell cycle reentry of the existing hepatocytes after PH is seemingly a hallmark of liver compensatory regeneration.Although the molecular control of the PH-triggered cell cycle reentry has been extensively studied,little is known about how the synchronization is achieved after PH.The nucleolus-localized protein cleavage complex formed by the nucleolar protein Digestive-organ expansion factor(Def)and cysteine proteinase Calpain 3(Capn3)has been implicated to control wounding healing during liver regeneration through selectively cleaving the tumor suppressor p53 in the nucleolus.However,whether the Def-Capn3 complex participates in regulating the synchronization of cell cycle reentry after PH is unknown.In this report,we generated a zebrafish capn3b null mutant(capn3b^(Δ19Δ14)).The homozygous mutant was viable and fertile,but suffered from a delayed liver regeneration after PH.Delayed liver regeneration in capn3b^(Δ19Δ14)was due to disruption of synchronized cell proliferation after PH.Mass spectrometry(MS)analysis of nuclear proteins revealed that a number of negative regulators of cell cycle are accumulated in the capn3b^(Δ19Δ14)liver after PH.Moreover,we demonstrated that Check-point kinase 1(Chk1)and Wee1,two key negative regulators of G2 to M transition,are substrates of Capn3.We also demonstrated that Chk1 and Wee1 were abnormally accumulated in the nucleoli of amputated capn3bΔ19Δ14 liver.In conclusion,our findings suggest that the nucleolar-localized Def-Capn3 complex acts as a novel regulatory pathway for the synchronization of cell cycle reentry,at least partially,through inactivating Chk1 and Wee1 during liver regeneration after PH. | Feng Chen Delai Huang Hui Shi Ce Gao Yingchun Wang Jinrong Peng | 2020 | Cell Regeneration2020，9，1： | 0 |
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