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| 1 | Exploring the history of cultural exchange in prehistoric Eurasia from the perspectives of crop diffusion and consumption显示文摘The history of cultural exchange in prehistoric Eurasia(CEPE) has been widely investigated. Based on archaeological evidence, this process is thought to date back to at least the early Bronze Age, although details about timings and routes remain unclear. It is likely that CEPE promoted the spread and exchange of crops that originated in different parts of Eurasia; since these remains can be definitely identified and directly dated, they provide ideal research materials to explore the history of CEPE. In this paper, we review the available archaeobotanical evidence and direct radiocarbon dates for crop remains, alongside carbon isotopic data from human bones unearthed from prehistoric sites in Eurasia, in order to investigate the history of the spread of millet crops, and wheat and barley, that were first domesticated in the eastern and western parts of Eurasia during prehistoric times.In combination with other archaeological evidences, we discuss the history of CEPE. Our results suggest that wheat and barley were domesticated in western Asia around 10500 a BP, spread into Europe and western Central Asia before 8000 a BP, and reaching eastern Central Asia and northwestern China between 4500 and 4000 a BP. Data show that both broomcorn and foxtail millet were domesticated in eastern Asia before 7700 a BP, spread into eastern Central Asia between 4500 and 4000 a BP, and into western Asia and Europe prior to 3500 a BP. Wheat, barley, and millet crops were first utilized together in eastern Kazakhstan within Central Asia around 4400 a BP, the region where earliest CEPE is likely to have taken place. These crops were mixedly used mainly in eastern central Asia and northwest China between 4500 and 3500 a BP, and then across the Eurasia before 2200 a BP. The results of this study suggest that transcontinental CEPE might have been initiated during the fifth millennium, before intensifying during the Bronze Age to lay the foundations for the creation of the ancient Silk Road during the Han Dynasty(between 202 BC and 220AD). | DONG GuangHui YANG YiShi HAN JianYe WANG Hui CHEN FaHu | 2017 | Science China Earth Sciences2017，60，6： | 30 |
| 2 | Low C/N_0 Carrier Tracking Loop Based on Optimal Estimation Algorithm in GPS Software Receivers显示文摘Suppressing jitter noises in a phase locked loop(PLL) is of great importance in order to keep precise and continuous track of global positioning system(GPS) signals characterized by low carrier-to-noise ratio(C/N0).This article proposes and analyzes an improved Kalman-filter-based PLL to process weak carrier signals in GPS software receivers.After reviewing the optimal-bandwidth-based traditional second-order PLL,a Kalman-filter-based estimation algorithm is implemented for the new PLL by decorrelating the model error noises and the measurement noises.Finally,the efficiency of this new Kalman-filter-based PLL is verified by experimental data.Compared to the traditional second-order PLL,this new PLL is in position to make correct estimation of the carrier phase differences and Doppler shifts with less overshoots and noise disturbances and keeps an effective check on the disturbances out of jitter noises in PLL.The results show that during processing normal signals,this improved PLL reduces the standard deviation from 0.010 69 cycle to 0.007 63 cycle,and for weak signal processing,the phase jitter range and the Doppler shifts can be controlled within ±17° and ±5Hz as against ±25° and ±15 Hz by the traditional PLL. | Miao Jianfeng Chen Wu Sun Yongrong Liu Jianye | 2010 | Chinese Journal of Aeronautics2010，23，1： | 18 |
| 3 | Euphorbia factor L2 induces apoptosis in A549 cells through the mitochondrial pathway显示文摘Euphorbia factor L2, a lathyrane diterpenoid isolated from caper euphorbia seed(the seeds of Euphorbia lathyris L.), has been traditionally applied to treat cancer. This article focuses on the cytotoxic activity of Euphorbia factor L2 against lung carcinoma A549 cells and the mechanism by which apoptosis is induced. We analyzed the cytotoxicity and related mechanism of Euphorbia factor L2 with an MTT assay, an annexin V-FITC/PI test, a colorimetric assay, and immunoblotting. Euphorbia factor L2 showed potent cytotoxicity to A549 cells. Euphorbia factor L2 led to an increase in reactive oxygen species(ROS) generation,a loss of mitochondrial electrochemical potential, release of cytochrome c, activation of caspase-9 and caspase-3, and cleavage of poly(ADP-ribose) polymerase, suggesting that Euphorbia factor L2 induced apoptosis through a mitochondrial pathway. The cytotoxic activity of Euphorbia factor L2 in A549 cells and the related mechanisms of apoptotic induction provide support for the further investigation of caper euphorbia seeds. | Minting Lin Sili Tang Chao Zhang Hubiao Chen Wenjing Huang Yun Liu Jianye Zhang | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 14 |
| 4 | Molecular Characterization of a Leaf Senescence-Related Transcription Factor BrWRKY75 of Chinese Flowering Cabbage显示文摘WRKY is a plant-specific transcription factor(TF) involved in the regulation of many biological processes; however, its role in leaf senescence of leafy vegetables remains unknown. In the present work, a WRKY TF, termed Br WRKY75 was isolated from Chinese flowering cabbage [Brassica rapa L. ssp. chinensis(L.) Mokino var. utilis Tsen et Lee]. Analysis of deduced amino acid sequence and the phylogenetic tree showed that Br WRKY75 has high homology with WRKY75 from Brassica oleracea and Arabidopsis thaliana, and belongs to the II c sub-group. Sub-cellular localization and transcriptional activity analysis revealed that Br WRKY75 is a nuclear protein with transcriptional repression activity, and was up-regulated during leaf senescence. Electrophoretic mobility shift assay confirmed that Br WRKY75 directly bound to the W-box(TTGAC) cis-element. Collectively,these results provide a basis for further investigation of the transcriptional regulation of Chinese flowering cabbage leaf senescence. | TAN Xiaoli FAN Zhongqi LI Lulu WU Ya KUANG Jianfei LU Wangjin CHEN Jianye | 2016 | Horticultural Plant Journal2016，2，5： | 11 |
| 5 | A NAC transcription factor, NOR-like1, is a new positive regulator of tomato fruit ripening显示文摘Ripening of the model fruit tomato(Solanum lycopersicum)is controlled by a transcription factor network including NAC(NAM,ATAF1/2,and CUC2)domain proteins such as No-ripening(NOR),SlNAC1,and SlNAC4,but very little is known about the NAC targets or how they regulate ripening.Here,we conducted a systematic search of fruit-expressed NAC genes and showed that silencing NOR-like1(Solyc07g063420)using virus-induced gene silencing(VIGS)inhibited specific aspects of ripening.Ripening initiation was delayed by 14 days when NOR-like1 function was inactivated by CRISPR/Cas9 and fruits showed obviously reduced ethylene production,retarded softening and chlorophyll loss,and reduced lycopene accumulation.RNA-sequencing profiling and gene promoter analysis suggested that genes involved in ethylene biosynthesis(SlACS2,SlACS4),color formation(SlGgpps2,SlSGR1),and cell wall metabolism(SlPG2a,SlPL,SlCEL2,and SlEXP1)are direct targets of NOR-like1.Electrophoretic mobility shift assays(EMSA),chromatin immunoprecipitation-quantitative PCR(ChIP-qPCR),and dual-luciferase reporter assay(DLR)confirmed that NOR-like1 bound to the promoters of these genes both in vitro and in vivo,and activated their expression.Our findings demonstrate that NOR-like1 is a new positive regulator of tomato fruit ripening,with an important role in the transcriptional regulatory network. | Ying Gao Wei Wei Xiaodan Zhao Xiaoli Tan Zhongqi Fan Yiping Zhang Yuan Jing Lanhuan Meng Benzhong Zhu Hongliang Zhu Jianye Chen Cai-Zhong Jiang Donald Grierson Yunbo Luo Da-Qi Fu | 2018 | Horticulture Research2018，5，1： | 9 |
| 6 | Study of the Surface Morphology of Gas Hydrate显示文摘Study of the surface morphology of gas hydrate is of great importance in understanding its physical properties and occurrence.In order to investigate the surface morphology of different types(sI and sII)and occurrences(pore-filling and fracture-filling)of gas hydrate,both lab-synthesized and drilled-gas hydrate samples were measured using cryo-scanning electron microscopy(cryo-SEM).Results showed that the surface of s I hydrate was relatively smooth,and spongy nano-pores(200–400 nm)gradually occurred at the surface during continuous observation.The surface of sII hydrate was more compact,showing a tier-like structure.Hydrate occurred in quartz sand and usually filled the pores of the sediments and both hydrate and sediments were cemented with each other.SEM observation of the gas hydrates collected from the South China Sea showed that the surface morphology and contact relation with sediments varied with hydrate occurrence.For instance,hydrates dispersed in sediments mainly filled the pores of the sediments.The existence of microorganism shells,such as foraminifera,was beneficial to the formation of gas hydrate.When hydrate occurred as a massive or vein structure,it was easily distinguished from the surrounding sediments.The surface of hydrate with massive or vein structure showed two distinct characters:one was dense and smooth,the other is porous(several to tens of micrometers in diameter).The occurrence of different hydrate morphologies was probably caused by the supplement rates of methane gas. | SUN Jianye LI Chengfeng HAO Xiluo LIU Changling CHEN Qiang WANG Daigang | 2020 | Journal of Ocean University of China2020，19，2： | 9 |
| 7 | Validation of dynamic cavitation model for unsteady cavitating flow on NACA66显示文摘Unsteady cavitating flow is extremely complicated and brings more serious damages and unignorable problems compared with steady cavitating flow.CFD has become a practical way to model cavitation;however,the popularly used full cavitation model cannot reflect the pressure-change that the bubble experiences during its life path in the highly unsteady flow like cloud cavitating.Thus a dynamic cavitation model(DCM)is proposed and it has been considered to have not only the first-order pressure effects but also zero-order effect and can provide greater insight into the physical process of bubble producing,developing and collapsing compared to the traditional cavitation model.DCM has already been validated for steady cavitating flow,and the results were reported.Furthermore,DCM is designed and supposed to be more accurate and efficient in modeling unsteady cavitating flow,which is also the purpose of this paper.The basic characteristic of the unsteady cavitating flow,such as the vapor volume fraction distribution and the evolution of pressure amplitude and frequency at different locations of the hydrofoil,are carefully studied to validate DCM.It is found that not only these characteristics mentioned above accord well with the experimental results,but also some detailed transient flow information is depicted,including the re-entrant jet flow that caused the shedding of the cavity,and the phenomenon of two-peak pressure fluctuation in the vicinity of the cavity closure in a cycle.The numerical results validate the capability of DCM for the application of modeling the complicated unsteady cavitating flow. | ZHANG XiaoBin ZHANG Wei CHEN JianYe QIU LiMin SUN DaMing | 2014 | Science China(Technological Sciences)2014，57，4： | 8 |
| 8 | Exosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrinα2β1显示文摘Exosomes play critical roles in regulating various physiological and pathological processes,including immune stimulation,immune suppression,cardiovascular diseases,and cancers.Recent studies show that exosomes that transport specific microRNAs(miRNAs)are involved in tumor development.However,the molecular mechanism by which tumor invasion and migration are regulated by exosomes from non-small cell lung cancer(NSCLC)is not well understood.Here,we show that exosomes shuttling low levels of miR-34c-3p are involved in NSCLC progression.Our results showed that exosomes derived from NSCLC cells carrying low levels of miR-34c-3p could be transported into the cytoplasm of NSCLC cells and accelerate NSCLC invasion and migration by upregulating integrinα2β1.A luciferase assay revealed that integrinα2β1 was the direct target of miR-34c-3p,and overexpression of integrinα2β1 could promote the invasion and migration of NSCLC cells.The analysis of exosomes derived from clinical serum samples indicated that the expression of miR-34c-3p was significantly downregulated in exosomes from NSCLC patients compared with that of normal controls.A549-derived exosomes promoted NSCLC cells lung metastases in vivo.Exosomes shuttling low levels of miR-34c-3p were associated with the progression of NSCLC in vitro and in vivo.Our data demonstrate that exosomes shuttling low levels of miR-34c-3p can accelerate the invasion and migration of NSCLC by upregulating integrinα2β1.MiR-34c-3p can be a diagnostic and prognostic marker for NSCLC.High expression of integrinα2β1 is positively related to the migration and metastasis of NSCLC cells. | Wenjing Huang Yanyan Yan Yun Liu Minting Lin Jinxiang Ma Wei Zhang Jianwei Dai Jiajun Li Qiaoru Guo Hubiao Chen Bolat Makabel Hong Liu Chaoyue Su Hong Bi Jianye Zhang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 9 | Role of Co Content on Densification and Microstructure of WC–Co Cemented Carbides Prepared by Selective Laser Melting显示文摘WC–Co cemented carbides, well-known as the conventional tooling materials, have not been successfully produced by one step additive manufacturing processes such as selective laser melting(SLM) yet. The microstructure evolution as well as WC grain growth behavior has rarely been investigated in detail during SLM process. In this study, the WC–Co cemented carbides with different Co contents(12–32 wt%) were prepared by optimized SLM processes for comparative investigation of densification behavior, microstructure characterization and mechanical property. The increase in Co content in feedstock carbide granules can improve the densification behavior during SLM process. The SLM processed WC-12 Co shows larger average WC grain size and higher percentage of coarser WC grains as compared with both WC-20 Co and WC-32 Co. The microstructure characterization, combined with finite element simulation, shows the WC grain growth mechanisms include agglomeration and dissolution-deposition of WC during SLM process and agglomeration of WC is an important mechanism especially for WC–Co cemented carbides with Co content as low as 12 wt%. The comparison between horizontal(perpendicular to the SLM laser beam) and vertical(parallel to the SLM laser beam) cross sections of carbides shows that SLM process introduces a certain degree of microstructure and mechanical behavior anisotropy for WC-12 Co, WC-20 Co, and WC-32 Co. | Jinyang Liu Jian Chen Li Zhou Bingyao Liu Yang Lu Shanghua Wu Xin Deng Zhongliang Lu Zhipeng Xie Wei Liu Jianye Liu Zhi Qu | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，9： | 5 |
| 10 | A comprehensive testing method for global stability analysis of high arch dams显示文摘Hydropower projects are rapidly developing in China at present,and a number of high dams and large reservoirs are currently under construction or will soon be built.These large projects are mainly located on the great rivers in West China with complicated topographical and geological conditions.Evaluation of stability and safety of these high dam projects is an important topic.Geomechanical model test is one of the main methods to study the global stability of high dam and foundation.In this paper,a comprehensive testing method that combines overloading and strength reduction in a model is proposed.In this method,both the influence of excessive flooding and the effects of strength reduction of rock masses and weak structural planes on dam stability are considered.Thus,the comprehensive testing method can accurately incorporate multiple factors that affect the global stability of high dam and its foundation.Based on the failure testing principle and model similarity theory,a similarity relation formula for safety evaluation through comprehensive test is established.A new model material,temperature-dependent analogous material,is also developed.By rising the temperature and reducing the strength of the model material,the mechanical behaviors resulting from gradual strength reduction can be simulated.Thus,the comprehensive testing method is realized in a single model.For case studies,the comprehensive geomechanical model test is conducted for Jinping I and Xiaowan high arch dam projects. | Lin Zhang Yuan Chen Baoquan Yang Jianye Chen Chengqiu Hu | 2012 | Journal of Rock Mechanics and Geotechnical Engineering2012，4，1： | 3 |
| 11 | Bilateral coordinate boundary adaptive control for a helicopter lifting system with backlash-like hysteresis显示文摘Dear editor,A helicopter lifting system which includes a helicopter,a cable,and a load has been extensively used in civilian and military applications and has received increasing attention[1-3].Generally,a disturbance acting on a cable should be considered as a distributed disturbance.Thus,in this study,the helicopter lifting system is depicted by a distributed parameter system.However,the dynamic of the load and external disturbance may pose significant impediments to the stabilization problem and potentially degrade the control performance of the helicopter lifting system.Therefore,the effective control method is urgent to be developed for restraining oscillation for the helicopter lifting system. | Yong REN Mou CHEN Jianye LIU | 2020 | Science China(Information Sciences)2020，63，1： | 3 |
| 12 | Internal structures and high-velocity frictional properties of Longmenshan fault zone at Shenxigou activated during the 2008 Wenchuan earthquake显示文摘This paper reports internal structures of a wide fault zone at Shenxigou,Dujiangyan,Sichuan province,China,and high-velocity frictional properties of the fault gouge collected near the coseismic slip zone during the 2008 Wenchuan earthquake.Vertical offset and horizontal displacement at the trench site were 2.8 m(NW side up)and 4.8 m(right-lateral),respectively.The fault zone formed in Triassic sandstone,siltstone,and shale about 500 m away from the Yingxiu-Beichuan fault,a major fault in the Longmenshan fault system.A trench survey across the coseismic fault,and observations of outcrops and drill cores down to a depth of 57 m revealed that the fault zone consists of fault gouge and fault breccia of about0.5 and 250–300 m in widths,respectively,and that the fault strikes N62°E and dips 68° to NW.Quaternary conglomerates were recovered beneath the fault in the drilling,so that the fault moved at least 55 m along the coseismic slip zone,experiencing about 18 events of similar sizes.The fault core is composed of grayish gouge(GG) and blackish gouge(BG) with very complex slip-zone structures.BG contains low-crystalline graphite of about 30 %.High-velocity friction experiments were conducted at normal stresses of 0.6–2.1 MPa and slip rates of 0.1–2.1 m/s.Both GG and BG exhibit dramatic slip weakening at constant high slip rates that can be described as an exponential decay from peak friction coefficient lpto steadystate friction coefficient lssover a slip-weakening distance Dc.Deformation of GG and BG is characterized by overlapped slip-zone structures and development of sharp slickenside surfaces,respectively.Comparison of our data with those reported for other outcrops indicates that the high-velocity frictional properties of the Longmenshan fault zones are quite uniform and the high-velocity weakening must have promoted dynamic rupture propagation during the Wenchuan earthquake. | Yu Wang Shengli Ma Toshihiko Shimamoto Lu Yao Jianye Chen Xiaosong Yang Honglin He Jiaxiang Dang Linfeng Hou Tetsuhiro Togo | 2014 | Earthquake Science2014，27，5： | 3 |
| 13 | Perspective on gallium-based room temperature liquid metal batteries显示文摘Recent years have witnessed a rapid development of deformable devices and epidermal electronics that are in urgent request for flexible batteries.The intrinsically soft and ductile conductive electrode materials can offer pivotal hints in extending the lifespan of devices under frequent deformation.Featuring inherent liquidity,metal-licity,and biocompatibility,Ga-based room-temperature liquid metals(GBRTLMs)are potential candidates to fulfill the requirement of soft batteries.Herein,to illustrate the glamour of liquid components,high-temperature liquid metal batteries(HTLMBs)are briefly summarized from the aspects of principle,application,advantages,and drawbacks.Then,Ga-based liquid metals as main working electrodes in primary and secondary batteries are reviewed in terms of battery configurations,working mechanisms,and fiinctions.Next,Ga-based liquid metals as auxiliary working electrodes in lithium and nonlithium batteries are also discussed,which work as functional self-healing additives to alleviate the degradation and enhance the durability and capacity of the battery system.After that,Ga-based liquid metals as interconnecting electrodes in multi-scenarios including photovoltaics solar cells,generators,and supercapacitors(SCs)are interpreted,respectively.The summary and perspective of Ga-based liquid metals as diverse battery materials are also focused on.Finally,it was suggested that tremendous endeavors are yet to be made in exploring the innovative battery chemistry,inherent reaction mechanism,and multifunctional integration of Ga-based liquid metal battery systems in the coining future. | Zerong XING Junheng FU Sen CHEN Jianye GAO Ruiqi ZHAO Jing LIU | 2022 | Frontiers in Energy2022，16，1： | 3 |
| 14 | A Banana PHD-Type Transcription Factor MaPHD1 Represses a Cell Wall-Degradation Gene MaXTH6 during Fruit Ripening显示文摘Plant homeobox domain(PHD)-type transcription factors(TFs) are involved in a variety of biological processes. However, its involvement in commercially important fruit ripening process remains largely unclear. In the present work, the characterization of a PHD-type TF termed MaPHD1 from banana fruit is reported. Multiple alignments of the deduced amino acid sequence revealed that Ma PHD1 showed a high homology with Arabidopsis thaliana Alfin1-like proteins belonging to plant-specific sub-family of PHD finger proteins. MaPHD1 was found localized in the nucleus and exhibited trans-repression ability. It was down-regulated by ethylene and ripening. Electrophoretic Mobility Shift Assay(EMSA) and transient expression analysis demonstrated that Ma PHD1 directly bound to the G-rich motifs in the promoter of Ma XTH6, which is associated with cell wall degradation, and subsequently repressed its expression. These findings suggest that MaPHD1 may be negatively associated with banana fruit ripening, at least in part, by the direct suppression of Ma XTH6. Taken together, these findings provide new insights into the transcriptional regulatory networks of banana fruit ripening. | WEI Wei FAN Zhongqi CHEN Jianye KUANG Jianfei LU Wangjin SHAN Wei | 2017 | Horticultural Plant Journal2017，3，5： | 2 |
| 15 | Methionine oxidation and reduction of the ethylene signaling component MaEIL9 are involved in banana fruit ripening显示文摘The ethylene insensitive 3/ethylene insensitive3-like(EIN3/EIL)plays an indispensable role in fruit ripening.However,the regulatory mechanism that links post-translational modification of EIN3/EIL to fruit ripening is largely unknown.Here,we studied the expression of 13 MaE IL genes during banana fruit ripening,among which MaE IL9 displayed higher enhancement particularly in the ripening stage.Consistent with its transcript pattern,abundance of MaE IL9 protein gradually increased during the ripening process,with maximal enhancement in the ripening.DNA affinity purification(DAP)-seq analysis revealed that MaE IL9 directly targets a subset of genes related to fruit ripening,such as the starch hydrolytic genes MaA MY3D and MaB AM1.Stably overexpressing MaE IL9 in tomato fruit hastened fruit ripening,whereas transiently silencing this gene in banana fruit retarded the ripening process,supporting a positive role of MaEIL9 in fruit ripening.Moreover,oxidation of methionines(Met-129,Met-130,and Met-282)in MaEIL9 resulted in the loss of its DNA-binding capacity and transcriptional activation activity.Importantly,we identified MaEIL9 as a potential substrate protein of methionine sulfoxide reductase A MaMsrA4,and oxidation of Met-129,Met-130,and Met-282in MaEIL9 could be restored by MaMsrA4.Collectively,our findings reveal a novel regulatory network controlling banana fruit ripening,which involves MaMsrA4-mediated redox regulation of the ethylene signaling component MaEIL9. | Lisha Zhu Lin Chen Chaojie Wu Wei Shan Danling Cai Zengxiang Lin Wei Wei Jianye Chen Wangjin Lu Jianfei Kuang | 2023 | Journal of Integrative Plant Biology2023，65，1： | 1 |
| 16 | Asynchronous abdominal wall and sigmoid metastases in clear cell renal cell carcinoma: A case report and literature review显示文摘Sigmoid metastasis of renal cell carcinoma(RCC)is very rare.Herein we report a case of pathologically proven asynchronous abdominal wall and sigmoid metastases after a right nephrectomy.An 84-year-old man underwent right radical nephrectomy for clear cell renal cell carcinoma(ccRCC)13 years ago.Solitary contralateral abdominal wall metastasis was found for left abdominal mass 9 years after nephrectomy.The man experienced melena underwent resection of sigmoid colon tumor in February,2016.The postoperative pathological examinations revealed that the tumors were metastases of ccRCC.Recurrence more than 5 years after nephrectomy has been accepted as late recurrence by the majority of urologists now.Late recurrence is one of the specific biological behaviors of RCC.Asynchronous late recurrence of abdominal wall and sigmoid metastases in ccRCC has not been reported before.When patients have sigmoid mass after nephrectomy for RCC,doctors may consider the possibility of late recurrence. | Fangyuan Zhang Gang Zhao Pengjie Wu Qi An Yang Yang Xin Chen Jianye Wang Dong Wei | 2019 | Asian Journal of Urology2019，6，2： | 1 |
| 17 | Spatial variability in soil heat flux at three Inner Mongolia steppe ecosystems显示文摘 | Changliang Shao Jiquan Chen Linghao Li Wenting Xu Shiping Chen Tenney Gwen Jianye Xu Wenli Zhang | 2008 | Agricultural and Forest Meteorology2008，，10： | 1 |
| 18 | Investigation on hydrodynamic lubrication of bearings in a left ventricular assisted device显示文摘Formations of clots were found inside the hydrodynamic bearings of the left ventricular assisted devices (LVADs) and caused tremendous risks to the long-term use of these devices. For the hydrodynamic bearings used in the LVAD, not only the lubrication status but also the motion of the blood cells in the bearing will take great effect on the performance of the device. Based on the analysis of the hydrodynamic pressures distribution and the flowing trajectory of red blood cells in the lubrication film, the bearing is designed in a region where enough hydrodynamic pressure is generated to float the rotor to reduce the wear, and the entrainment of red blood cells in the gap of the bearing can be prevented to avoid the formation of clots. | Xiaobing ZHENG Yongjian LI Haosheng CHEN Shengshou HU Jianye ZHOU | 2020 | Friction2020，8，4： | 1 |
| 19 | Dl-3-n butylphthalide attenuates brain injury caused by cortical infarction accompanied by cranial venous drainage disturbance显示文摘Background Cerebral venous disorder may have a harmful effect on ischaemic stroke;however,the underlying mechanism remains to be elucidated.Although Dl-3-n butylphthalide is a multitarget agent for antiischaemic stroke,its neuroprotective role in brain ischaemia accompanied by brain venous disturbance remains unclear.In this study,we induced cerebral venous disturbance by the occlusion of bilateral external jugular veins(EJVs)to explore the potential mechanism of the adverse effects of cerebrovenous disorders in cerebral infarction and explore the protective effect of Dl-3-n butylphthalide on cerebral infarction accompanied through cerebral venous disturbance.Methods Cerebral venous disturbance was induced in Sprague-Dawley rats through the permanent occlusion of bilateral EJVs,and cerebral ischaemic stroke was induced through the permanent occlusion of the right cortical branches of the middle cerebral artery.2,3,5-triphenyltetrazolium chloride staining,MRI,Evans blue extravasation and behavioural test were performed to evaluate infarction volume,cerebral blood flow(CBF),blood-brain barrier(BBB)integrity and neurological function.Immunofluorescence staining and western blot analysis were performed to detect loss of neuron,endothelial cells,pericytes and tight junctions.Results Bilateral EJVs occlusion did not cause cerebral infarction;however,it increased the infarction volume compared with the simple middle cerebral artery occlusion(MCAO)group,accompanied by severe neuron loss,worse neurological function,lower CBF,increased EJVs pressure,exacerbated Evans blue extravasation and brain oedema,as well as attenuated angiogenesis.Dl-3-n butylphthalide displayed a neuroprotective effect in rats with MCAO accompanied by EJVs occlusion by reducing neuron loss,accelerating CBF restoration,promoting angiogenesis and relieving BBB damage.Conclusion Bilateral EJVs occlusion did not significantly affect normal rats but aggravated brain damage in the case of ischaemic stroke.Dl-3-n butylphthalide treatment plays a neuroprotective role in rats with MCAO accompanied by EJVs occlusion,mainly due to the promotion of CBF restoration and BBB protection. | Kangping Song Xiuli Zeng Xiaomei Xie Rongxuan Zhu Jianye Liang Guobing Chen Li’an Huang | 2022 | Stroke & Vascular Neurology2022，7，3： | 1 |
| 20 | Changes and subcellular localizations of the enzymes involved in phenylpropanoid metabolism during grape berry development显示文摘 | Chen JianYe Wen PengFei Kong WeiFu | 2006 | J Plant Physio12006，163，2： | 1 |
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