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| 1 | Aflibercept for diabetic macular oedema: a Meta-analysis of randomized controlled trials显示文摘AIM: To evaluate the relative efficacy and safety of aflibercept for treatment of diabetic macular oedema(DMO).METHODS: A comprehensive search in MEDLINE, CENTRAL and EMBASE was undertaken for randomized controlled trials(RCTs) comparing intravitreal antivascular endothelial growth factor(anti-VEGF) versus another treatment. Primary outcome measures were proportion of patients with at least 15 letters of gain or loss on a log MAR visual acuity chart, and change in best corrected visual acuity(BCVA) and central macular thickness(CMT) from baseline. Safety outcomes were rates of death, thromboembolic events and any systemic or ocular serious adverse events. The final search was performed on November 2017.RESULTS: Four RCTs were included. Only one trial compared efficacy and safety of aflibercept with bevacizumab and ranibizumab over 1 or 2 y. Three trials were included for Meta-analysis comprising 661 patients(331 in the aflibercept, and 330 in the photocoagulation group). Aflibercept was more efficacious compared to photocoagulation in the proportion of patients with at least 15 letters of improvement and worsening, and in improvement of BCVA and reduction in CMT at 1 or 2 y. The safety estimates at 1 or 2 y did not differ statistically.CONCLUSION: Aflibercept offers superior benefits over photocoagulation in improving and preserving vision, with no differences in safety. Further comparative effectiveness trials between aflibercept and other anti-VEGF agents will aid ophthalmologists in treatment decisions. | Chu Luan Nguyen Andrew Lindsay Eugene Wong Michael Chilov | 2018 | International Journal of Ophthalmology(English edition)2018，11，6： | 2 |
| 2 | Novel human vascular endothelial growth factor genes VEGF-B and VEGF-C localize to chromosomes 11q13 and 4q34,respectively显示文摘 | Horelli-Kuitonen N Chilov D | 1996 | Circulation1996，93，6： | 1 |
| 3 | Novelhuman vascular endothelial growth factor genes VEGF-Band VEGF-C localize to chromosomes 11q13and 4q34,respectively显示文摘 | Paavonen K Horelli-Kuitunen N Chilov D | 1996 | Circulation1996，93，6： | 1 |
| 4 | Knowledge logistics in information grid environment显示文摘 | Alexander Smirnov Mikhail Pashkin Nikolai Chilov | 2004 | Future Generation Computer Systems2004，20，： | 1 |
| 5 | Novel human vascular endothelial growth factor genes VEGF- B and VEGF- C localize to chromosomes 11 q13 and 4q34, respectively显示文摘 | Paavonen K Horelli-Kuitunen N Chilov D | 1996 | Circulation1996，93，6： | 1 |
| 6 | Novel human vascular endothelial growth factor genes VEGF-B and VEGF-C localize to chromosomoes 11q13 and 4q34, respectively 显示文摘 | Paavonen K Horelli-Kuitunen N Chilov D | 1996 | Circulation1996，93，6： | 1 |
| 7 | Induction and nuclear translocation of hypoxia - inducible factor - 1 ( HIF - 1 ) : heterodimerization with ARNT is not necessary for nuclear accumulation of HIF- 1 alpha 显示文摘 | Chilov D Camenisch G Kvietikova I | 1999 | J Cell Sci1999，112，8： | 1 |
| 8 | Hypoxia affects expression of circadian genes PER1 and CLOCK in mouse brain显示文摘 | Chilov D Hofer T Bauer C | 2001 | FASEB J2001，15，14： | 1 |
| 9 | Induction and nuclear translocation of hypoxia-inducible factor-1(HIF-1):hettranslocation with ARNT is not necessary for nuclear accumulation of HIF-1α显示文摘 | Chilov D Camenisch G Kvietikova I | 1999 | J Cell Sci1999，112，15： | 1 |
| 10 | Novel human vascular endothelial growth factor genes VEGF - B and VEGF- C lovalize to chromosomes 11q13 and 4q34, respectively显示文摘 | Paavonen K Horelli Kuitunen N Chilov D | 1996 | Circulation1996，93，10： | 1 |
| 11 | Novel human vascular endothelial growth factor genes VEGF-B and VEGF C localize to chromosomes 11q13 and 4q34, respectively 显示文摘 | Paavonen K Horelli-Kuitunen N Chilov D | 1996 | Circulation1996，93，6： | 1 |
| 12 | Regulation of the hypoxia-inducible factor-1 alpha ARNT is not necessary for hypoxic induction of HIF-1 alpha in the nucleus显示文摘 | GASSMANN M CHILOV D WENGER R H | 2000 | Adv Exp Med Biol2000，475，： | 1 |
| 13 | Knowledge logistics in information grid environment显示文摘 | Smirnov A Pashkin M Chilov N | 2004 | Future Generation Computer Systems2004，20，1： | 1 |
| 14 | Genomic organization of human and mouse gene for vascular endothelial growth factor C显示文摘 | Chilov D Kukk E Taira S | 1997 | Biol Chem1997，272，25： | 1 |
| 15 | Novel hum&n v&scul&r endotheli&l growth f&ctors genes VEGF-B &nd V EC-F-C Ioc&lize to chromosomes 11 q5 &nd 4q54, respectively显示文摘 | Pa&vonen K Hrelli-Kuitunen N Chilov D | | Circul&tion 9960，95，6： | 1 |
| 16 | Regulation of the hypoxia-inducible factor-1 alpha,ARNT is not necessary for hypoxic induction of HIF-1 alpha in the nucleus显示文摘 | Chilov D Wenge RH | 2000 | Adv Exp Med Biol2000，475，： | 1 |
| 17 | Knowledge logistics in information grid environment 显示文摘 | SMIRNOV A PASHKIN M CHILOV N | 2004 | Feature Generation Computer Systems2004，20，1： | 1 |
| 18 | Novel human vascular endothelial growth factor genes YEGF-B and VEGF-C localize to chromosomes 11q13 and 4q34, respectively显示文摘 | Paavonen K Horelli-Kuitunen N Chilov D | 1996 | Circulation1996，93，6： | 1 |
| 19 | Novel human vascular endothelial growth factor genes VEGF-B and VEGF-C localize to chromosomes 11q13 and 4q34,respectively显示文摘 | Horelli Kuitunen N Chilov D | 1996 | Circulation1996，93，6： | 1 |
| 20 | Regulation of the hypoxia-inducible factor-1 alpha ARNT is not necessary for hypoxic induction of HIF-1 alpha in the nucleus显示文摘 | Gassmann M Chilov D Wenger R | 2000 | Adv Exp Med Biol2000，475，2： | 1 |
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