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| 1 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 2 | Effects of the phase-separated melt on crystallization behavior and morphology in short chain branched metallocene polyethylenes显示文摘 | Fu Q Chiu F C McCreight K W Guo M Tseng W W Cheng S Z Keating M Y Hsieh E T and DesLauriers P J | | 0，，： | 2 |
| 3 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 4 | Computed tomography angiography imaging for the chimeric anterolateral thigh flap in reconstruction of full thickness buccal defect显示文摘 | CHIU W K LIN W C CHEN S Y | 2011 | ANZ J Surg2011，81，3： | 1 |
| 5 | A 12-bit,45-MS/s,3-mW Redundant Successive-approximation-register Analog-to-digital Converter with Digital Calibration 显示文摘 | Liu W Huang P Chiu Y | 2011 | IEEE Journal of Solid-state Circuits2011，46，11： | 1 |
| 6 | Thermal degradation behavior of poly - styrene blended with propyl ester phosphazene显示文摘 | Denq B L Chiu W Y Chen L W | 1997 | Polym Degrad Stabil1997，57，： | 1 |
| 7 | Analysis of food colorants by capillary electrophoresis with large-volume sample stacking 显示文摘 | Huang H Y Chiu C W Sue S L | 2003 | J Chromatogr A2003，995，12： | 1 |
| 8 | Thermal stability performance of anisotropic conductive film at different bonding temperatures显示文摘 | CHAN Y C CHIU Y W | 2003 | Microelectronics Reliability2003，43，： | 1 |
| 9 | Cooperative communications in resource-constrained wireless networks 显示文摘 | HONG Y W I-tUANG W J CHIU F H | 2007 | IEEE Signal Processing Magazine2007，24，3： | 1 |
| 10 | A robust objectsegmentation system using a probability-based back-ground extraction algorithm显示文摘 | CHIU CH CH KU M Y LIANG L W | 2010 | IEEE Transactions onCircuits and Systems or Video Technology2010，20，4： | 1 |
| 11 | Mechanical properties of a porcine aortic valve fixed with a naturally occurring crosslinking agent显示文摘 | Sung H W Chang Y Chiu C T | 1999 | Biomaterials1999，20，： | 1 |
| 12 | A computer-assisted colour selection system based on aesthetic measure for colour harmony and fuzzy logic theory显示文摘 | Hsiao S W Chiu F Y Hsu H Y | | 0，，05： | 1 |
| 13 | Regression analysis for the sorption isotherms of basic dyes on sugarcane dust显示文摘 | Ho Y S Chiu W T Wang C C | 2005 | Bioresour Techonl2005，96，： | 1 |
| 14 | Thermal degradation behavior and phisical properties for poly ( methy methacrylate) blended with propyl ester phosphazene 显示文摘 | Denq B L Chiu W Y Chen L W | 1997 | Polym Degrad Stabil1997，57，： | 1 |
| 15 | Cooperative Communications in Resource-constrained Wireless Net- works 显示文摘 | HONG Y W HUANG W J CHIU F H | 2007 | IEEE Signal Processing Magazine2007，24，3： | 1 |
| 16 | Pour orchid (Oncidium Gow,, Ramsey) AP1/AGL9-1ike MADS box genes show noveJ expression patterns and cause different effects on floral transition and formation in Arabidopsis thaliana 显示文摘 | Chang Y Y Chiu Y F Wu J W | 2009 | Plant and Cell Physiology2009，50，8： | 1 |
| 17 | Noninvasive prenatal detection of trisomy 21 by an epigenetic-genetic chromosome-dosage approach 显示文摘 | Tong Y K Jin S Chiu R W | 2010 | Clin Chem2010，56，1： | 1 |
| 18 | Luminescence and energy transfer mechanism in Ca10K(PO4)7: Eu^2+ , Mn^2+ phosphor 显示文摘 | Liu W R Chiu Y C Yeh Y T Jang S M Chen T M | 2009 | Journal of the Electrochemical Society2009，156，7： | 1 |
| 19 | A study of synthetic forsterite refractory materials using waste serpentine cutting 显示文摘 | T W Cheng Y C Ding J P Chiu | 2002 | Minerals Engineering2002，，8： | 1 |
| 20 | Adaptive compressive spectrum sensing for wideband cognitive radios显示文摘 | Sun H Chiu W Y and Nallanathan A | 2012 | IEEE Communications Letters2012，16，11： | 1 |
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