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| 1 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 2 | Generalized set-valued variational inclusions in Banach spaces 显示文摘 | Chang S S Cho Y J Lee B S | 2000 | J Math Anal Appl2000，246，： | 2 |
| 3 | A study of magnetic and optical properties of Cu-doped ZnO 显示文摘 | LEE H J KIM B S CHO C R | 2004 | Phys Status Solidi B2004，241，7： | 1 |
| 4 | Dispersion polymerization of acrylamide with quaternary ammonium cationic comonomer in aqueous solution显示文摘 | Song B K Cho M S Yoon K J | 2003 | J Appl Polym Sci2003，87，： | 1 |
| 5 | Application of interactive genetic algorithm to fashion design显示文摘 | Kim H S Cho S B | 2000 | Engineering Applications of Artificial Intelligence2000，13，6： | 1 |
| 6 | An anti-apoptotic protein human survivin is a direct inhibitor of Caspase-3 and-7显示文摘 | Sung B J Cho YS Kim H J Ha NC Hwang JI | 2001 | Biochenistry2001，40，4： | 1 |
| 7 | Initial experience with a gasless unilateral axillo-breast or axillary approach endo- scopic thyroidectomy for papillary thyroid microcarci- noma: comparison with conventional open thyroidectomy显示文摘 | Tae K Ji Y B Cho S H | 2011 | Surg Laparosc Endosc Percutan Tech2011，21，2： | 1 |
| 8 | Colorectal canc-er cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endo-thelial cells显示文摘 | HONG B S CHO J H KIM H | 2009 | BMC Genomics2009，10，： | 1 |
| 9 | A novel electrochemical detection method for aptamer biosensors显示文摘 | Bang G S Cho S Kim B G | 2005 | Biosensors and Bioelectronics2005，21，： | 1 |
| 10 | Analysis of difference fairing based on DFT-filter 显示文摘 | Cho S K Choi B K | 2001 | Computer-Aided Design2001，33，1： | 1 |
| 11 | Synthesis, characterization, and electroluminescence of new conjugated polyfluorene derivatives containing various dyes as comonomers 显示文摘 | CHO N S HWANG D H JUNG B J | 2004 | Macromolecules2004，37，14： | 1 |
| 12 | Changes in the microstructure and hydrogen storage properties of Ti℃r-V alloys by ball milling and heat treatment 显示文摘 | CHO S W YOO J H CHANG H K KIM W B KIL D S AHN J G | 2011 | Journal of Alloys and Compounds2011，509，18： | 1 |
| 13 | Mirtazapine augmentation enhances cognitive and reduces negative symptoms in schizophrenia patients treated with risperidone:A randomized controlled trial显示文摘 | Cho S J Yook K Kim B | 2011 | Prog Neu- ropsychopharmacol Biol Psyehiatry2011，35，1： | 1 |
| 14 | Two-dimensional photonic crystal color filter development显示文摘 | E H Cho H S Kim B H Cheong | | 0，，10： | 1 |
| 15 | On an elementary operator with w-hyponormal operator entries 显示文摘 | Cho M Djordjevic S V Duggal B P Yamazaki T | 2010 | Linear Algebra Appl2010，433，： | 1 |
| 16 | A synergistic interaction between transcription factors nuclear factor-KB and signal transducers and activators of transcription 3 promotes gastric cancer cell migration and invasion显示文摘 | Yoon J Cho S Lee B | 2013 | BMC Gastroenterol2013，13，： | 1 |
| 17 | Three-dimensional ima- ging of undercut and sidewall structures by atomic force mi- croscopy 显示文摘 | Cho S J Ahn B W Kim J | 2011 | Review of Scientific Instruments2011，82，02： | 1 |
| 18 | Suppliers' affective trust and trust in competency in buyers: Its effect on collaboration and logistics effi- ciency 显示文摘 | HA B C PARK Y K CHO S | 2011 | International Journal of Operations & Production Management2011，31，1： | 1 |
| 19 | Application of interactive genetic to fashion design 显示文摘 | Kim H S Cho S B | 2000 | Engineering Applications of Artificial Intelligence2000，13，6： | 1 |
| 20 | Multispectral detection of organic residues on poultry processing plant equipment based on hyperspectral refl ectance imaging technique显示文摘 | Cho B K Chen Y R Kim M S | 2007 | Computers and Electronics in Agriculture2007，57，2： | 1 |
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