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| 1 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 2 | A study of magnetic and optical properties of Cu-doped ZnO 显示文摘 | LEE H J KIM B S CHO C R | 2004 | Phys Status Solidi B2004，241，7： | 1 |
| 3 | Application of interactive genetic algorithm to fashion design显示文摘 | Kim H S Cho S B | 2000 | Engineering Applications of Artificial Intelligence2000，13，6： | 1 |
| 4 | An anti-apoptotic protein human survivin is a direct inhibitor of Caspase-3 and-7显示文摘 | Sung B J Cho YS Kim H J Ha NC Hwang JI | 2001 | Biochenistry2001，40，4： | 1 |
| 5 | Initial experience with a gasless unilateral axillo-breast or axillary approach endo- scopic thyroidectomy for papillary thyroid microcarci- noma: comparison with conventional open thyroidectomy显示文摘 | Tae K Ji Y B Cho S H | 2011 | Surg Laparosc Endosc Percutan Tech2011，21，2： | 1 |
| 6 | Colorectal canc-er cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endo-thelial cells显示文摘 | HONG B S CHO J H KIM H | 2009 | BMC Genomics2009，10，： | 1 |
| 7 | Pediatric pineal tumors: need for a drect surgical approach and compilcations of the occiptal transtentorial approch显示文摘 | SHIN H J CHO B K JUNG H W | 1998 | Childs Nerv Syst1998，14，： | 1 |
| 8 | Overexpress cyclooxygenase2 is associated with a poor prognosis in patients with squamous cell carcinoma of the treated with radiation and concurrent chemotherapy显示文摘 | Kim Y B Kim G E Cho N H | 2002 | Cancer2002，95，： | 1 |
| 9 | Synthesis, characterization, and electroluminescence of new conjugated polyfluorene derivatives containing various dyes as comonomers 显示文摘 | CHO N S HWANG D H JUNG B J | 2004 | Macromolecules2004，37，14： | 1 |
| 10 | Changes in the microstructure and hydrogen storage properties of Ti℃r-V alloys by ball milling and heat treatment 显示文摘 | CHO S W YOO J H CHANG H K KIM W B KIL D S AHN J G | 2011 | Journal of Alloys and Compounds2011，509，18： | 1 |
| 11 | Investigation of residual stress and post weld heat treatment of multi-pass welds by finite element method and experiments 显示文摘 | Cho J R Lee B Y Moon Y H | 2004 | Journal of Materials Processing Technology2004，，： | 1 |
| 12 | Biomechanical analysis of the range of motion after placement of a two-level cervical ProDisc-C versus hybrid construct显示文摘 | Cho BY Lira J Sire H B | 2012 | Spine2012，35，19： | 1 |
| 13 | Two-dimensional photonic crystal color filter development显示文摘 | E H Cho H S Kim B H Cheong | | 0，，10： | 1 |
| 14 | Application of interactive genetic to fashion design 显示文摘 | Kim H S Cho S B | 2000 | Engineering Applications of Artificial Intelligence2000，13，6： | 1 |
| 15 | Case study on rate-based traffic control of industrial networks employing Lonworks显示文摘 | Kin B H Park K S | 2002 | International Journal of Systems Science2002，33，3： | 1 |
| 16 | Vagal hyperactivity in stress induced gastric ulceration in raLs显示文摘 | Qui B S Brace I C | 1996 | J Gastroenterol Hepatol1996，11，2： | 1 |
| 17 | Single dose versus fractionated stereotactic radiotherapy for recurrent high-grade gliomas显示文摘 | Cho K H Hall W A Gerbi B J | 1999 | Int J Radiat Oncol Biol Plays1999，45，5： | 1 |
| 18 | Molecular genetiC diversity and population structure in Lycium accessions using SSR markers显示文摘 | Zhao W G Chung J W Cho Y I Rha W H Lee G A Ma K H Han S H Bang K H Park C B Kim S M Park Y J | 2010 | C R Bioi2010，333，： | 1 |
| 19 | Mechanical valve replacement versus bioprosthetic valve replacement in the tricuspid valve position显示文摘 | Cho W C Park C B Kim J B Jung S H Chung C H Choo S J | 2013 | J Card Surg2013，28，： | 1 |
| 20 | Alkyl-fluoroalkylimidazolium-based ionic liquids as efficient CO 2 absorbents显示文摘 | LEE H CHO M H LEE B S | 2010 | Energy & Fuels2010，24，12： | 1 |
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