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| 1 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 2 | Dispersion polymerization of acrylamide with quaternary ammonium cationic comonomer in aqueous solution显示文摘 | Song B K Cho M S Yoon K J | 2003 | J Appl Polym Sci2003，87，： | 1 |
| 3 | Initial experience with a gasless unilateral axillo-breast or axillary approach endo- scopic thyroidectomy for papillary thyroid microcarci- noma: comparison with conventional open thyroidectomy显示文摘 | Tae K Ji Y B Cho S H | 2011 | Surg Laparosc Endosc Percutan Tech2011，21，2： | 1 |
| 4 | A grazing incidence X ray streak camera for ultrafast, single-shot measurements显示文摘 | Feng J Engelhorn K Cho B I | 2010 | Appl Phys Lett2010，96，13： | 1 |
| 5 | Pediatric pineal tumors: need for a drect surgical approach and compilcations of the occiptal transtentorial approch显示文摘 | SHIN H J CHO B K JUNG H W | 1998 | Childs Nerv Syst1998，14，： | 1 |
| 6 | Analysis of difference fairing based on DFT-filter 显示文摘 | Cho S K Choi B K | 2001 | Computer-Aided Design2001，33，1： | 1 |
| 7 | Changes in the microstructure and hydrogen storage properties of Ti℃r-V alloys by ball milling and heat treatment 显示文摘 | CHO S W YOO J H CHANG H K KIM W B KIL D S AHN J G | 2011 | Journal of Alloys and Compounds2011，509，18： | 1 |
| 8 | Mirtazapine augmentation enhances cognitive and reduces negative symptoms in schizophrenia patients treated with risperidone:A randomized controlled trial显示文摘 | Cho S J Yook K Kim B | 2011 | Prog Neu- ropsychopharmacol Biol Psyehiatry2011，35，1： | 1 |
| 9 | Suppliers' affective trust and trust in competency in buyers: Its effect on collaboration and logistics effi- ciency 显示文摘 | HA B C PARK Y K CHO S | 2011 | International Journal of Operations & Production Management2011，31，1： | 1 |
| 10 | Multispectral detection of organic residues on poultry processing plant equipment based on hyperspectral refl ectance imaging technique显示文摘 | Cho B K Chen Y R Kim M S | 2007 | Computers and Electronics in Agriculture2007，57，2： | 1 |
| 11 | Case study on rate-based traffic control of industrial networks employing Lonworks显示文摘 | Kin B H Park K S | 2002 | International Journal of Systems Science2002，33，3： | 1 |
| 12 | Dispersion polymeri-zation of acrylamide in aqueous solution ammoniumsulfate:synthesis and characterization显示文摘 | Cho M S Yoon K J Song B K | 2002 | Journal ofApplied Polymer Science2002，83，7： | 1 |
| 13 | Single dose versus fractionated stereotactic radiotherapy for recurrent high-grade gliomas显示文摘 | Cho K H Hall W A Gerbi B J | 1999 | Int J Radiat Oncol Biol Plays1999，45，5： | 1 |
| 14 | Renal function is associated with bone mineral density and arterial stiffness in healthy postmenopausal women显示文摘 | Seo S K Lee B S Cho S | 2010 | Bone2010，47，1： | 1 |
| 15 | Molecular genetiC diversity and population structure in Lycium accessions using SSR markers显示文摘 | Zhao W G Chung J W Cho Y I Rha W H Lee G A Ma K H Han S H Bang K H Park C B Kim S M Park Y J | 2010 | C R Bioi2010，333，： | 1 |
| 16 | Phytochemical con- stituents from the fruits of Acanthopanax sessiliflorus显示文摘 | Lee S Kim B K Cho S H | 2002 | Archibes of pharmacal research2002，25，3： | 1 |
| 17 | Evidence of double layer quantum dot formation in a silicon-on-insulator nanowires transistor显示文摘 | CHO K H CHOI B H SON S H | 2005 | Appl Phys Lett2005，86，043101： | 1 |
| 18 | Multivariate analysis of risk factors of hematoma expansion in spontaneous intraeerebral hemorrhage显示文摘 | Lira J K Hwang H S Cho B M | 2008 | Surg Neueol2008，69，1： | 1 |
| 19 | Untreated asymptomatic hips in patients with osteonecrosis of the femoral head显示文摘 | MIN B W SONG K S CHO C H | 2008 | Clin Orthop Relat Res2008，466，5： | 1 |
| 20 | Water vapor permeability of shape memory polyurethane with amorphous reversible phase 显示文摘 | Jeong H M Ahn B K Cho S M | 2000 | Journal of Polymer Science Part B: Polymer Physics2000，38，： | 1 |
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