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| 1 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 2 | Digital inkjet printing for chitosan-treated cotton fabric显示文摘 | P S R Choi C W M Yuen S K A Ku | 2005 | Fibers and Polymers2005，6，3： | 1 |
| 3 | Kojic acid - amino acid amide metal complexes and their melanogenesis inhibitory activities 显示文摘 | KWAK S Y CHOI H R PARK K C | 2011 | J Pept Sci2011，17，： | 1 |
| 4 | Numerical investigation on the flow, combustion and NOx emission characteristics in a 500 MW tangentially fired pulverized-coal boiler显示文摘 | Choi C R Kim C N | 2009 | Fuel2009，88，9： | 1 |
| 5 | Development of collagenase-resistant collagen and its interaction with adult human dermal fibroblasts显示文摘 | Goo H C Hwang Y S Choi Y R | 2003 | Biomaterials2003，24，28： | 1 |
| 6 | Ethnic Differences in Adolescents' Mental Distress, Social Stress, and Resources 显示文摘 | CHOI H MEININGER J C ROBERTS R E | 2006 | Adolescence2006，41，142： | 1 |
| 7 | Current status of gynecological cancer in China显示文摘 | Kim K Zang R Choi S C | 2009 | J Gynecol Oncol2009，20，2： | 1 |
| 8 | Stereotactic radiosurgical treatment of cranial and spinal hemangioblastomas显示文摘 | Moss J M Choi C Y Adler J R | 2009 | Neurosurgery2009，65，1： | 1 |
| 9 | Calculation of mixed lubrica- tion at piston ring and cylinder liner interface 显示文摘 | CHO M R CHOI J K HAN D C | 2001 | KSME Inter- national Jouenal2001，15，7： | 1 |
| 10 | Numerical investigation on the flow, combustion and NOx emission characteris- tics in a 500 MW~ tangentially fired pulverized-coal boiler 显示文摘 | CHOI C R KIM C N | 2009 | Fuel2009，88，9： | 1 |
| 11 | Shape Optimization of the Cavitator for a Supercavitating Torpedo显示文摘 | Choi J H Penmetsa R C Grandhi R V | 2005 | Struct Multidisc Optim2005，29，： | 1 |
| 12 | Modeling the effects of oxygenated fuels and split injections on DI diesel engine performance and emissions 显示文摘 | Choi C Y Reitz R D | 2000 | Combustion Science and Technology2000，159，： | 1 |
| 13 | Anti-HIV protease activity from Rosa Family plant extracts and rosamultin from Rosa rugosa显示文摘 | Park J C Kim S C Choi M R | 2005 | J Med Food2005，8，1： | 1 |
| 14 | Mixture adsorption equilibria of ethane and ethylene on 13X molecular sieves显示文摘 | Danner R Choi E C F | 1978 | Ind Eng Chem Fundam1978，17，1： | 1 |
| 15 | Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury显示文摘 | TENG Y D CHOI H ONARIO R C | 2004 | Proc Natl Acad Sci USA2004，101，9： | 1 |
| 16 | Anti-inflammatory properties of anthraquinones and their relationship with the regulation ofp-glycoprotein function and expression显示文摘 | Choi R J Ngo C T M Bae K | 2013 | Eur J Pharm Sci2013，48，12： | 1 |
| 17 | Retrovirus-mediated gene transfer and expression of EGFP in chicken显示文摘 | KOO B C KWN M S CHOI B R | 2004 | Mol Reprod Dev2004，68，4： | 1 |
| 18 | Expression of NDRG2 is re- lated to tumor progression and survival of gastric cancer patients through Fas-mediated cell death显示文摘 | Choi S C Yoon S R Park Y P | 2007 | Exp Mol Med2007，39，6： | 1 |
| 19 | Lack of effect of induction of hypothermia after acute brain injury显示文摘 | Clifton G L Miller E R Choi S C | 2001 | N Engl J Med2001，344，： | 1 |
| 20 | Flame/Flow Interaction in Oscillat- ing Flow Field 显示文摘 | Choi C Y Reitz R D | 2000 | Combustion Science and Technology2000，159，1： | 1 |
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