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| 1 | Gilbert's syndrome: High frequency of the (TA)_7 TAA allele in India and its interaction with a novel CAT insertion in promoter of the gene for bilirubin UDP-glucuronosyltransferase 1 gene显示文摘瞄准:在吉伯的症候群(GS ) 在 UDP-glucuronosyltransferase 1 (UGT1A1 ) 基因识别变体并且在印度在正常控制之中在 TA 插入和它的影响的印度,以及频率为 TA 插入和 GS 估计在纯合性之间的协会。方法:95 个 GS 盒子和 95 正常控制被选择。肝工作,另外的测试被做。倡导者和 UGT1A1 基因的所有 5 前 ons 被重新定序。对新奇 trinucleotide 插入的功能的评价被做由在 silico 分析并且由估计 UGT1A1,倡导者活动在 Hep G2 由适当构造的酶记者试金执行了房间线。结果:在 GS 病人之中, 80% 为 TA 插入是同型结合的,它比从另外的种族组的报告高好几倍。吝啬的 UCB 水平与仅仅这插入的一个拷贝在个人之中被提高,它不与有二个拷贝的那些显著地不同。在 UGT1A1 基因的许多新 DNA 变体被发现,包括在倡导者的插入在 GS 病人的一个子集(10%) 发现了的 trinucleotide (猫) ,然而并非在正常之中控制。In-silico 分析证明在倡导者和功能的分析的合拢 DNA 的显著变化在 UGT1A1 基因源于这插入的抄写效率显示出 20 褶层减小,显著地从而提高 UCB 水平。结论:GS 的基因传染病学越过种族组是可变的,在 UGT1A1 倡导者变体之中的上位相互作用调制胆红素 glucuronidation。 | Shabana Farheen Sanghamitra Sengupta Amal Santra Suparna Pal Gopal Krishna Dhali Meenakshi Chakravorty Partha P Majumder Abhijit Chowdhury | 2006 | World Journal of Gastroenterology2006，12，14： | 29 |
| 2 | Systems Biology of Plant-Microbiome Interactions显示文摘In natural environments,plants are exposed to diverse microbiota that they interact with in complex ways.While plant-pathogen interactions have been intensely studied to understand defense mechanisms in plants,many microbes and microbial communities can have substantial beneficial effects on their plant host.Such beneficial effects include improved acquisition of nutrients,accelerated growth,resilience against pathogens,and improved resistance against abiotic stress conditions such as heat,drought,and salinity.However,the beneficial effects of bacterial strains or consortia on their host are often cultivar and species specific,posing an obstacle to their general application.Remarkably,many of the signals that trigger plant immune responses are molecularly highly similar and often identical in pathogenic and beneficial microbes.Thus,it is unclear what determines the outcome of a particular microbe-host interaction and which factors enable plants to distinguish beneficials from pathogens.To unravel the complex network of genetic,microbial,and metabolic interactions,including the signaling events mediating microbe-host interactions,comprehensive quantitative systems biology approaches will be needed. | Patricia A.Rodriguez Michael Rothballer Soumitra Paul Chowdhury Thomas Nussbaumer Caroline Gutjahr Pascal Falter-Braun | 2019 | Molecular Plant2019，12，6： | 20 |
| 3 | Biochar and its importance on nutrient dynamics in soil and plant显示文摘Biochar,an environmentally friendly soil conditioner,is produced using several thermochemical processes.It has unique characteristics like high surface area,porosity,and surface charges.This paper reviews the fertilizer value of biochar,and its effects on soil properties,and nutrient use efficiency of crops.Biochar serves as an important source of plant nutrients,especially nitrogen in biochar produced from manures and wastes at low temperature(≤400℃).The phosphorus,potassium,and other nutrient contents are higher in manure/waste biochars than those in crop residues and woody biochars.The nutrient contents and pH of biochar are positively correlated with pyrolysis temperature,except for nitrogen content.Biochar improves the nutrient retention capacity of soil,which depends on porosity and surface charge of biochar.Biochar increases nitrogen retention in soil by reducing leaching and gaseous loss,and also increases phosphorus availability by decreasing the leaching process in soil.However,for potassium and other nutrients,biochar shows inconsistent(positive and negative)impacts on soil.After addition of biochar,porosity,aggregate stability,and amount of water held in soil increase and bulk density decreases.Mostly,biochar increases soil pH and,thus,influences nutrient availability for plants.Biochar also alters soil biological properties by increasing microbial populations,enzyme activity,soil respiration,and microbial biomass.Finally,nutrient use efficiency and nutrient uptake improve with the application of biochar to soil.Thus,biochar can be a potential nutrient reservoir for plants and a good amendment to improve soil properties. | Md Zahangir Hossain Md Mezbaul Bahar Binoy Sarkar Scott Wilfred Donne Young Sik Ok Kumuduni Niroshika Palansooriya Mary Beth Kirkham Saikat Chowdhury Nanthi Bolan | 2020 | Biochar2020，2，4： | 15 |
| 4 | Immune response to an indigenously developed r-Hepatitis B vaccine in mixed population: Study of an accelerated vaccination schedule显示文摘AIM: To establish the safety and efficacy of an indigenously developed r-hepatitis B vaccine using an accelerated schedule and to highlight the social awareness and commitment in preventing the spreading of hepatitis B virus infection.METHODS: The study was a multicentric, double blind,randomized (3:1) study using three doses of vaccine immunization schedule (20 μg for those above 10 years old and 10 μg for those below 10 years old) on d 0, 30and 60. One hundred and sixty-six subjects were enrolled(87 males and 76 females aged 5-35 years). The main outcome measure was assessment of immunogenicity and safety.RESULTS: A 100% seroconversion response was observed on the 30th d after the 1st injection in both the experimental groups. The sero-protection data reported a 41.2-65.6% response on the 30th d after the 1st injection and reached 100% on the 60th d. Descriptive statical analysis showed a geometric mean titer value of 13.77 mIU/mL in the test (BEVAC) group and 10.95 mIU/mL in the commercial control (ENGERIX-B) group on the 30th d after the 1st injection. The response on the 60th d showed a geometric mean titre value (GMT) of 519.84 mIU/mL in the BEVAC group and 475.46 mIU/mL in the ENGERIX-B group. On the 90th d, the antibody titer response was observed to be 2627.58 mIU/mL in the BEVAC group and 2272.72 mIU/mL in the ENGERIX-B group. Two subjects in each group experienced pains at injection site after the first vaccination. A total of six subjects in both groups experienced a solicited adverse reaction, which included pains, swelling and redness at the injection site, three subjects in the group-B had a pain at the injection site after the third dose. No other serious adverse events occurred and no dose-related local or general symptoms were observed during the study.CONCLUSION: The vaccine is safe, efficacious and immunogenic in comparison with the well documented ENGERIX-B. | A Chowdhury A Santra CM Habibullah AA Khan J Karunakaramaiah TSA Kishore AVR Raju S Lahiri | 2005 | World Journal of Gastroenterology2005，11，7： | 12 |
| 5 | Laboratory simulated dissipation of metsulfuron methyl and chlorimuron ethyl in soils and their residual fate in rice, wheat and soybean at harvest显示文摘Two sulfonylurea herbicides, metsulfuron methyl (Ally 20 WP) and chlorimuron ethyl (Classic 25 WP) were evalu-ated for their dissipation behaviour in alluvial, coastal saline and laterite soils under laboratory incubated condition at 60% water holding capacity of soils and 30 °C temperature was maintained. In field study herbicides were applied twice for the control of grasses, annual and perennials broad leaves weeds and sedges in rice, wheat and soybean to find out the residual fate of both the herbicides on different matrices of respective crops after harvest. Extraction and clean up methodologies for the herbicides were standardized and subsequently analyzed by HPLC. The study revealed that the half-lives of metsulfuron methyl and chlorimuron ethyl ranged from 10.75 to 13.94 d irrespective of soils and doses applied. Field trials with rice, wheat and soybean also revealed that these two herbicides could safely be recommended for application as no residues were detected in the harvest samples. | SANYAL Nilanjan PRAMANIK Sukhendu Kumar PAL Raktim CHOWDHURY Ashim | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，3： | 11 |
| 6 | Celulose Paper-based Strapping Products for Green/Sustainable Packaging Needs显示文摘Paper products such as corrugated paperboards are the most common green packaging materials, which are renewable, sustainable, recyclable and biodegradable. However, the plastic or metal straps used to secure the carton boxes are not so green. At the end of packaging, the carton boxes can be recycled, but the plastic/metal straps have to be sorted out for disposal separately. This review focuses on: 1) the global trend of green packaging;2) conventional plastic/metal strapping materials for carton boxes;3) conventional market pulp baling with steel wire as the tying materials;4) cellulose fiber-based materials for strapping market pulp bales and carton boxes. New generation of cellulose paper straps are being developed for more challenging applications with superior strength properties and repulpability. | Zhibin He Amit Chowdhury Li Tong Mike Reynolds Yonghao Ni | 2019 | Paper And Biomaterials2019，4，3： | 11 |
| 7 | 植物乳杆菌KLDS 1.0318对小鼠免疫调节作用初步研究显示文摘目的:探讨植物乳杆菌KLDS 1.0318对小鼠免疫调节功能的影响。方法:将健康的BALB/c小鼠随机分为4组,即正常对照组、乳酸菌低剂量组、乳酸菌中剂量组、乳酸菌高剂量组。灌胃不同剂量植物乳杆菌KLDS 1.0318菌悬液后,分别测定各组脾脏指数和胸腺指数,脾淋巴细胞增殖、NK细胞活性、巨噬细胞能量代谢水平,巨噬细胞吞噬能力。结果:与正常对照组相比,植物乳杆菌KLDS 1.0318中、高剂量组能够显著提高小鼠的脾脏和胸腺指数,同时能够促进脾淋巴细胞增殖,增强小鼠NK细胞活性,提高小鼠巨噬细胞吞噬中性红能力及其能量代谢水平。结论:植物乳杆菌KLDS 1.0318可以通过促进机体的特异性免疫和非特异性免疫功能来增强机体的免疫作用。 | 蒙月月 sathi Chowdhury shuvan kumar sarker 霍贵成 | 2018 | 食品工业科技2018，39，7： | 8 |
| 8 | 氟比洛芬酯超前镇痛复合不同剂量舒芬太尼对小儿骨盆截骨矫形术后镇痛效果的比较显示文摘目的比较氟比洛芬酯超前镇痛复合不同剂量舒芬太尼对小儿骨盆截骨矫形术术后镇痛的效果,寻找适合小儿的术后镇痛模式。方法于我院小儿骨科选取拟于全麻下行骨盆截骨矫形术的3~10岁的先天性髋脱位病儿90例,将病儿随机分为N1、N2、N3共3组。3组切皮前均给予静脉注射氟比洛芬酯1mg/kg超前镇痛,病人自控镇痛(PCA)所用舒芬太尼的剂量分别为1.5、2.0、2.5μg/kg。PCA泵中昂丹司琼含量均为0.1mg/kg,加生理盐水至100mL。记录各组病儿在麻醉恢复室拔除气管插管时间,病儿术后2、4、8、12、24、48h的FLACC疼痛评分和Ramsay镇静评分,术后48h内PCA按压次数以及恶心、呕吐、呼吸抑制等不良反应。结果 3组病儿在恢复室的术后拔管时间差异无统计学意义(P>0.05)。FLACC评分比较,术后4、8、12h,N2组、N3组低于N1组,N3组低于N2组,差异有统计学意义(F=3.664~84.558,P<0.05);术后24、48h,N3组低于N1组,差异有统计学意义(F=4.225、8.667,P<0.05)。Ramsay评分比较,术后4、8、12h,N2组和N3组高于N1组,差异有统计学意义(F=5.367~24.996,P<0.05);术后24、48h,N3组高于N1组,差异有统计学意义(F=14.073、6.074,P<0.05)。术后48h内PCA泵按压次数,N1组13次,N2组7次,N3组3次,差异有统计学意义(χ~2=6.410,P<0.05)。N3组术后48h内恶心、呕吐发生率高于N1组和N2组,差异有统计学意义(χ~2=7.587,P<0.05)。结论氟比洛芬酯1mg/kg超前镇痛复合舒芬太尼2.0μg/kg是一种理想的小儿骨盆截骨矫形术的PCA模式。 | Alvira Jafar Chowdhury 王瑞伟 王公明 王旭 张孟元 | 2017 | 齐鲁医学杂志2017，32，1： | 7 |
| 9 | Development of polyvinylpyrrolidone/paclitaxel self-assemblies for breast cancer显示文摘The goal of this investigation was to develop and demonstrate a polymer/paclitaxel selfassembly(PTX-SA) formulation. Polymer/PTX-SAs were screened based on smaller size of formulation using dynamic light scattering analysis. Additionally, fluorescence microscopy and flow cytometry studies exhibited that polyvinylpyrrolidone(PVP)-based PTX-SAs(PVP/PTX-SAs) had superior cellular internalization capability in MCF7 and MDA-MB-231 breast cancer cells. The optimized PVP/PTXSAs exhibited less toxicity to human red blood cells indicating a suitable formulation for reducing systemic toxicity. The formation of PVP and PTX self-assemblies was confirmed using fluorescence quenching and transmission electron microscopy which indicated that the PVP/PTX-SAs were spherical in shape with an average size range of 53.81 nm as detected by transmission electron microscopy(TEM).FTIR spectral analysis demonstrates incorporation of polymer and paclitaxel functional groups in PVP/PTX-SAs. Both proliferation(MTS) and clonogenic(colony formation) assays were used to validate superior anticancer activity of PVP/PTX-SAs in breast cancer cells over paclitaxel. Such superior anticancer activity was also demonstrated by downregulation of the expression of pro-survival protein(Bcl-x L), upregulation of apoptosis-associated proteins(Bid, Bax, cleaved caspase 7, and cleaved PARP)and β-tubulin stabilization. These results support the hypothesis that PVP/PTX-SAs improved paclitaxel delivery to cancer cells. | Pallabita Chowdhury Prashanth K.B.Nagesh Sheema Khan Bilal B.Hafeez Subhash C.Chauhan Meena Jaggi Murali M.Yallapu | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 7 |
| 10 | 在孟加拉国的不含酒精的脂肪肝疾病病人的不含酒精的 steatohepatitis显示文摘 AIM: To explore the prevalence and risk factors for nonalcoholic steatohepatitis (NASH) in nonalcoholic fatty liver disease (NAFLD) patients. METHODS: We have included 493 patients with sonographic evidence of a fatty change, and 177 of these individuals were evaluated and confirmed after liver biopsy. The exclusion criteria consisted of significant alcohol abuse (< 20 g daily), evidence of hepatitis B and C, evidence of drug-induced fatty liver disease and other specific liver diseases such as hemochromatosis, Wilson’s disease or autoimmune liver disease. The patients were assessed for metabolic syndrome, and biochemical, anthropometric and histopathological evaluations were carried out. The degree of disease activity in the NAFLD patients was evaluated using the NAFLD Activity Score. The data were analyzed by SPSS, version 16.0. RESULTS: Females predominated among the study participants (250, 57.0%), and the mean age was 40.8 ± 10.2 years. The numbers of overweight, obeseⅠ and obese Ⅱ patients were 58 (13.2%), 237 (53.9%) and 93 (21.2%), respectively. However, there were 422 (96.2%) centrally obese patients. NASH was absent in 10 (5.6%) cases, borderline in 92 (52.6%) cases and present in 75 (42.4%) cases. The presence of diabetes could significantly (P = 0.001) differentiate NASH from simple steatosis. The following parameters did not influence the development of NASH: age, sex, basal metabolic index, waist circumference, serum high-density lipoprotein, triglyceride, insulin resistance index, hypertension and metabolic syndrome. The serum gammaglutamyl transpeptidase (GGT) level was significantly higher (P = 0.05, 51.7 ± 32.8 and 40.4 ± 22.6 U/L) in the NASH patients, with a sensitivity of 45% and a specificity of only 68%. The serum alanine aminotransferase and aspartate aminotransferase levels were not able to predict NASH. CONCLUSION: Females were the predominant sufferers of NAFLD in Bangladesh. The prevalence of NASH was high. Diabetes was found to be the main culprit in developing NASH. GGT was the only biochemical marker of NASH. We recommend liver biopsy in NAFLD patients who have diabetes and elevated GGT. | Shahinul Alam Sheikh Mohammad Noor-E-Alam Ziaur Rahman Chowdhury Mahabubul Alam Jahangir Kabir | 2013 | World Journal of Hepatology2013，5，5： | 7 |
| 11 | Inorganic arsenic: A non-genotoxic carcinogen显示文摘Inorganic arsenic induces a variety of toxicities including cancer. The mode of action for cancer and non-cancer effects involves the metabolic generation of trivalent arsenicals and their reaction with sulfhydryl groups within critical proteins in various cell types which leads to the biological response. In epithelial cells, the response is cell death with consequent regenerative proliferation. If this continues for a long period of time, it can result in an increased risk of cancer. Arsenicals do not react with DNA. There is evidence for indirect genotoxicity in various in vitro and in vivo systems, but these involve exposures at cytotoxic concentrations and are not the basis for cancer development. The resulting markers of genotoxicity could readily be due to the cytotoxicity rather than an effect on the DNA itself. Evidence for genotoxicity in humans has involved detection of chromosomal aberrations, sister chromatid exchanges in lymphocytes and micronucleus formation in lymphocytes, buccal mucosal cells, and exfoliated urothelial cells in the urine. Numerous difficulties have been identified in the interpretation of such results, including inadequate assessment of exposure to arsenic, measurement of micronuclei, and potential confounding factors such as tobacco exposure, folate deficiency, and others. Overall, the data strongly supports a non-linear dose response for the effects of inorganic arsenic. In various in vitro and in vivo models and in human epidemiology studies there appears to be a threshold for biological responses, including cancer. | Samuel M.Cohen Aparajita Chowdhury Lora L.Arnold | 2016 | Journal of Environmental Sciences2016，28，11： | 7 |
| 12 | Molecular signaling mechanisms of apoptosis in hereditary non-polyposis colorectal cancer显示文摘Colorectal cancer is the second most leading cause of cancer related deaths in the western countries. One of the forms of colorectal cancer is hereditary non-polyposis colorectal cancer (HNPCC), also known as 'Lynch syndrome'. It is the most common hereditary form of cancer accounting for 5%-10% of all colon cancers. HNPCC is a dominant autosomal genetic disorder caused by germ line mutations in mismatch repair genes. Human mismatch repair genes play a crucial role in genetic stability of DNA, the inactivation of which results in an increased rate of mutation and often a loss of mismatch repair function. Recent studies have shown that certain mismatch repair genes are involved in the regulation of key cellular processes including apoptosis. Thus, differential expression of mismatch repair genes particularly the contributions of MLH1 and MSH2 play important roles in therapeutic resistance to certain cytotoxic drugs such as cisplatin that is used normally as chemoprevention. An understanding of the role of mismatch repair genes in molecular signaling mechanism of apoptosis and its involvement in HNPCC needs attention for further work into this important area of cancer research, and this review article is intended to accomplish that goal of linkage of apoptosis with HNPCC. The current review was not intended to provide a comprehensive enumeration of the entire body of literature in the area of HNPCC or mismatch repair system or apoptosis; it is rather intended to focus primarily on the current state of knowledge of the role of mismatch repair proteins in molecular signaling mechanism of apoptosis as it relates to understanding of HNPCC. | Samar Hassen Nawab Ali Parimal Chowdhury | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，3： | 7 |
| 13 | Distribution of ^3H—nicotine in Rat Tissues Under the Influence of Simulated Microgravity显示文摘Rat tail suspension offers a useful model to reproduce physiologic responses to weightlessness.The present study was conducted in the head-down-tilt(HDT) rat model to assess changes in metabolism of body tissues employing 3H-nicotine. Twelve male rats were used in the study. Half of the rats were tail suspended at 30°for two weeks on a 12/12 light/dark cycle. During this period,body weight, food and fluid intakes were measured. At term, animals were anesthetized and injected IV withe a solution contaming 4 microuries of micotine. After 90 min the animals were sacrificed, exsanguinated and tissues (brain,blood,trachea,salivary gland,lung,heart,esophagus,spleen, kidneys and testes) were harvested. The distribution of 3H-nicotine per gram of each tissue was determinded and ealeulated as percent of total injected radioactivity. Final body weights of suspended ammals were significantly (P < 0.0 5) lower than those of eontrols(309±21 vs 350±11g). 3HNicotine waw retained in greatest amounts by the kindneys, followed inorder by salivary glands, spleen, and gastrointestinal tissues. compared to non-suspended control, the tissue retention of nicotine in suspended animals was decreased in the following tissues:esphyagus (25 %), aorta (25%). fundus (25%), trachea (22%), adrenals (18%), spleen (17 %), and pancreas (12 %). The decreased retention of mcotine in tissues from suspended animals may be indicative of the fluid shifts and changes in blood flow to those tissue beds. The lack of differnces in nicotine retention in liver and kidney between control and suspended groups may implicate a normal metabolic function of these organs even under simulated weightlessness. | PARIMAL CHOWDHURY MICHAEL E. SOULSBY AND JAMES N. PASLEY (Department of Physiology and Biophysics, University of Arkansas for Medical Scienses, Little Rock, Arkansas 72205, USA) | 1999 | Biomedical and Environmental Sciences1999，12，2： | 6 |
| 14 | A comprehensive review on energy storage in hybrid electric vehicle显示文摘The sharp inclination in the emissions from conventional vehicles contribute to a significant increase in environmental issues,besides the energy crises and low conversion efficiency leads to the evolution of electric vehicles(EV).Hybrid electric vehicles(HEV) have efficient fuel economy and reduce the overall running cost,but the ultimate goal is to shift completely to the pure electric vehicle.Despite this,the main obstruction of HEV is energy storage capability.An EV requires high specific power(W/kg) and high specific energy(W$h/kg) to increase the distance travelled and reduce the time required for charging.The main focus of this paper is on the energy sources as these are the main components in EVs towards making them eco-friendly and cost-effective.Various topologies of EV technology such as HEVs,plug-in HEVs,and many more have been discussed.These topologies of EVs are based on the diverse combination of batteries,fuel cells,super-capacitor,flywheels,regenerative braking systems,which are used as energy sources and energy storage devices. | Shrey Verma Shubham Mishra Ambar Gaur Subhankar Chowdhury Subhashree Mohapatra Gaurav Dwivedi Puneet Verma | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，5： | 6 |
| 15 | 利拉鲁肽对高脂诱导肥胖小鼠瘦素、脂肪分布及含量的影响显示文摘目的观察利拉鲁肽对高脂诱导的C57BL/6小鼠肥胖模型瘦素、体内脂肪含量及分布的影响。方法 4周龄C57BL/6小鼠60只,随机分为正常对照组(n=15)和高脂喂养组(n=45)。高脂喂养组给予40%脂肪含量高脂饲料喂养,正常对照组给予普通饲料喂养,构建肥胖小鼠模型至20周龄时,将造模成功的高脂喂养组随机分为利拉鲁肽组、饮食干预组(普通饲料喂养)和继续高脂喂养组(高脂饲料喂养),每组15只。利拉鲁肽组腹腔注射利拉鲁肽(稀释于双蒸水中)[100μg/(kg·d)],饮食干预组、继续高脂喂养组和正常对照组腹腔注射生理盐水[0.017 m L/(kg·d)]。监测记录各组体质量。药物干预12周后于10%水合氯醛麻醉下处死全部小鼠,利用磁共振测定小鼠体内脂肪含量,采用竞争法测定外周血瘦素含量,酶法测定外周血血脂水平。结果利拉鲁肽组体质量最低,与正常对照组、饮食干预组、继续高脂喂养组相比差异有统计学意义(P<0.05);利拉鲁肽组瘦素水平下降,与饮食干预组、继续高脂喂养组差异有统计学意义(P<0.05);利拉鲁肽组血脂水平下降,甘油三酯含量与正常对照组、继续高脂喂养组相比差异有统计学意义(P<0.05),总胆固醇含量仅与继续高脂喂养组差异有统计学意义(P<0.05);利拉鲁肽组脂肪总含量、肠系膜脂肪、附睾脂肪、肾周脂肪、肩胛下脂肪、皮下脂肪与其他各组比较均差异有统计学意义(P<0.05)。结论利拉鲁肽可明显减轻肥胖小鼠的体质量、降低瘦素水平,有降脂和调节脂肪分布的作用。 | 沙莎 Chowdhury Sumon Rahman 陈丽 何芹 张婧 范珊珊 孙磊 | 2016 | 山东大学学报(医学版)2016，54，8： | 5 |
| 16 | Natural Convection Heat Transfer From a Hot Rectangular and a Square Corrugated Plate to a Cold Flat Plate显示文摘Experimental study of natural convection heat transfer across air layers bounded by a lower hot rectangular and a square corrugated plates to an upper cold flat plate has been carried out. The surroundings of this space are adiabatic. The effect of the angle of inclination, the aspect ratio, the temperature potential and the Rayleigh number on average heat transfer coefficients are investigated within a range of 0°≤75°,, 2.33≤A≤6.33, 10°≤T ≤35°, and 3.29xl04≤RaL≤ 2.29x106. The developed correlation predicts well the experimental data within an error of ±15%. | M. A. R. Akhanda F. M. Chowdhury (Department of Mechanical Engineering, Bangladesh University of Engineering and Technology (BUET), Dhaka- 1000, Bangladesh) | 2000 | Journal of Thermal Science2000，9，3： | 5 |
| 17 | Mitochondrial DNA mutations-candidate biomarkers for breast cancer diagnosis in Bangladesh显示文摘Breast cancer is a major health problem that affects more than 24% of women in Bangladesh. Furthermore, among low-income countries including Bangladesh, individuals have a high risk for developing breast cancer. This study aimed to identify candidate mitochondrial DNA (mtDNA) biomarkers for breast cancer diagnosis in Bangladeshi women to be used as a preventive approach. We screened the blood samples from 24 breast cancer patients and 20 healthy controls to detect polymorphisms in the D-loop and the ND3-and ND4-coding regions of mtDNA by direct sequencing. Among 14 distinct mutations, 10 polymorphisms were found in the D-loop, 3 were found in the ND3-coding region, and 1 was found in the ND4-coding region. The frequency of two novel polymorphisms in the D-loop, one at position 16290 (Tins) and the other at position 16293 (A-del), was higher in breast cancer patients than in control subjects (position 16290: odds ratio = 6.011, 95% confidence interval = 1.2482 to 28.8411, P = 0.002; position 16293: odds ratio = 5.6028, 95% confidence interval = 1.4357 to 21.8925, P = 0.010). We also observed one novel mutation in the ND3-coding region at position 10316 (A > G) in 69% of breast cancer patients but not in control subjects. The study suggests that two novel polymorphisms in the D-loop may be candidate biomarkers for breast | Gazi Nurun Nahar Sultana Atiqur Rahman Abu Din Ahmed Shahinuzzaman Rowshan Ara Begum Chowdhury Faiz Hossain | 2012 | Chinese Journal of Cancer2012，31，9： | 5 |
| 18 | The genetics of nicotine dependence:Relationship to Pancreatic cancer显示文摘SmoKing or tobacco products continues to De a major cause of worldwide health problems. Epidemiological studies have shown that tobacco smoking is the greatest risk factor for the development of pancreatic cancer. Smokers who are able to quit smoking can reduce their risk of pancreatic cancer by nearly 50% within two years, however, their risk of developing pancreatic cancer remains higher than that of non-smokers for 10 years. Nicotine is the major psychoactive substance in tobacco, and is responsible for tobacco dependence and addiction. Recent evidence suggests that individuals have genetically based differences in their ability to metabolize nicotine, as well as genetic differences in the psychological reward pathways that may influence individual response to smoking initiation, dependence, addiction and cessation. Numerous associations have been reported between smoking behavior and genetic polymorphisms in genes that are responsible for nicotine metabolism. In addition, polymorphisms in genes that encode neurotransmitters and transporters that function in psychological reward pathways have been implicated in differences in smoking behavior. However, there is a large degree of between-study variability that demonstrates the need for larger, well-controlled case-control studies to identify target genes and deduce mechanisms that account for the genetic basis of inter-individual differences in smoking behavior. Understanding the genetic factors that increase susceptibility to tobacco addiction may result in more effective tobacco cessation programs which will, in turn, reduce the incidence of tobacco related disease, including pancreatic cancer. | Stewart L MacLeod Parimal Chowdhury | 2006 | World Journal of Gastroenterology2006，12，46： | 5 |
| 19 | Comparative analysis of some selected macronutrients of soil in orange orchard and degraded forests in Chittagong Hill Tracts,Bangladesh显示文摘Status of organic carbon (C), total nitrogen (N), available potassium (K), calcium (Ca) and phosphorus (P) in three different depths (0-5 cm, 5-15 cm and 15?30 cm) on two hill slopes of 35% and 55% in orange orchard cultivated by the Mro tribe of Chittagong Hill Tracts (CHTs) were evaluated and compared with those in degraded bush forests, through digging three profiles in each land use. The content of all the five nutrients was found to be higher in the soil of orange orchard than in the soil of forest. But the variation was not consistent for both the slopes. The content varied depth wise also, having the highest value in surface soil in case of both the land uses on both the slopes. A mean available K content was significantly higher in orange orchard than in forest on 55% slope, while it was lower on 35% slope. Surface soil contained the nutrients of K and Ca with the amount of 0.2905-mg·g^(-1) soil and 3.025-mg·g^(-1)soil respectively in the orchard, while 0.1934-mg·g^(-1) soil and 1.6083-mg·g^(-1) soil were respectively in the forest. Organic carbon and total nitrogen were found more or less similar in surface soil on both the land uses showing a slight difference. Available P was found only in orange orchard, and in forest it was too little in amount to detect by the spectrophotometer. The degraded forests were poor in nutrient content due to high rate of soil erosion, which would be possible to be improved by bringing it under tree cover as proved by the adaptation of orange orchard there. | Mohammad Shaheed Hossain Chowdhury Shampa Biswas Md. Abdul Halim S. M. Sirajul Haque Nur Muhammed Masao Koike | 2007 | Journal of Forestry Research2007，18，1： | 5 |
| 20 | Comparative evaluation of physical properties in soils of orange orchard and bushy forest in chittagong hill tracts, Banglandesh显示文摘对孟加拉国丘陵地带Mro部落经营的桔园与灌木林35%和55%两种坡地土壤物理性质进行了比较与评价。每一块用地内挖掘3个土壤剖面采集不同深度(0-5cm,5-15cm and 15-30cm)的土壤样品,测定土壤水分、有机质含量和土壤密度。最大持水量、田间持水量、干或湿土壤容重和土壤孔隙度的测定仅限于表层土壤。两种坡地桔园3个深度的土壤水分含量均显著高于灌木林地相同深度的土壤水分。桔园在55%坡地内土壤有机质含量低于林地含量值,而在35%坡地内的含量值则高于林地值。两块样地内上述两项测定值均在表层土壤中最高,且随土层深度的增加而降低。与灌木林地比较,桔园地表层土壤最大持水量、孔隙度和3个不同深度的土壤密度均较低。两块用地内不同坡地的表层土田间持水量有所差异,且桔园地干或湿表层土壤容重高于林地内的数值。表5参23。 | Mohammad Shaheed Hossain Chowdhury Md. Abdul Halim Shampa Biswas S. M. Sirajul Haque Nur Muhammed Masao Koike | 2007 | Journal of Forestry Research2007，18，3： | 4 |
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