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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | 选择性雄激素受体调节剂治疗迟发性男性性腺功能低下症显示文摘几种睾酮制剂用于治疗老年男性性腺功能减退。这些疗法在其便利性、灵活性、区域供应和费用等方面有区别,但有共同的药代动力学基础,同时缺乏长期安全性数据。简洁和成本较低的基于药代动力学的注册临床试验使得开发改善性的治疗迟发性性腺功能减退的新疗法的商业动机减少了。在前列腺、头发、皮肤受雄激素缺乏影响的患者中,选择性雄激素受体调节剂已被证明可以提供合成代谢的好处。(目前,选择性雄激素受体调节剂的临床进展集中在有限定身体功能的临床终点的急性肌肉萎缩和低体重)。在具有有益的药理、理想的药代动力学的选择性雄激素受体调节剂应用于治疗迟发性男性性腺功能低下症前,其在男性性腺功能低下治疗中关于临床缺陷的更清晰的监管是必须的。 | Christopher C Coss Amanda Jones Michael L Hancock Mitchell S Steiner James T Dalton | 2014 | Asian Journal of Andrology2014，16，2： | 3 |
| 3 | Hyper-X Post-Flight Trajectory Reconstruction显示文摘 | Christopher D K Paul V T Robert C B | 2006 | Journal of Spacecraft and Rockets2006，43，1： | 1 |
| 4 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 5 | Enhancement of mechanical properties of TiN/AlN multilayers by modb lying the number and the quality of interfaces显示文摘 | ANNE T CHRISTOPHE R CHRISTINE C | 2000 | Surface and Coatings Technology2000，124，： | 1 |
| 6 | A processing, characterization and marine biodegradation study of melt-extruded polyhydroxyalkanoate (pha) films显示文摘 | Christopher T Megan C Danielle F | 2008 | Journal of Polymers and Environment2008，16，1： | 1 |
| 7 | Identification of DNA binding motifs of the Mycobacterium tuberculosis PhoP/PhoR two-component signal transduction system显示文摘 | Mena C Christophe T Amine N | 2012 | PLoS ONE2012，7，42： | 1 |
| 8 | Analysis of the innate and adaptive phases of allograft rejection by cluster analysis of transcriptional profiles显示文摘 | Christopher K Mueller T F Ma C Y | 2002 | J Immunol2002，169，： | 1 |
| 9 | On learning conditional random fields for stereo:exploring model struc- tures and approximate inference 显示文摘 | Christopher J P Jerod J W Lain C T Daniel S | 2012 | International Journal of Computer Vision2012，99，3： | 1 |
| 10 | A practical guide to wavelet analy- sis 显示文摘 | Christopher T Gilbert P C | 1998 | Bulletin of American Meteorological Society1998，，1： | 1 |
| 11 | Cluster analysis for the extraction of sagittal gait patterns in children with cerebral palsy显示文摘 | Brigitte T Christopher J Pauline C | 2007 | Gait & Posture2007，25，2： | 1 |
| 12 | Effects of NOx, a-Fe203, y-Fe203, and HC1 on mercury transformations in a 7-kW coal combustion system 显示文摘 | Kevin C G Christopher J Z James E T | 2004 | Fuel Processing Technology2004，434，86： | 1 |
| 13 | Antinociceptive effect of antisense oligonucleotides against the vanilloid receptorVR1/TRPV1 显示文摘 | Christoph T Gillen C Mika J | 2007 | Neurochem Int2007，50，1： | 1 |
| 14 | Effect of field inoculation with sinorhizobium meliloti L33 on the composition of bacterial communities in rhizospheres of a target plant (Medicago sativa) and a non-target plant (Chenopodium album) Linking of 16S rRNA Gene-based single-strand conformation polymorphism community profiles to the diversity of cultivated bacteria显示文摘 | Frank S Christoph C T | 2000 | Appl Environ Microbiol2000，66，8： | 1 |
| 15 | A practical guide to wavelet analysis显示文摘 | Christopher T Gilbet P C | 1998 | Bulletin of the American Meteorological Society1998，79，1： | 1 |
| 16 | Pimecrolimus for the treatment of vulva lichen sclerosus:a report of 4 cases显示文摘 | Goldstein A T Marinoff S C Christopher K | 2004 | J Reprod Med2004，49，10： | 1 |
| 17 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
| 18 | Direct and indirect photolysis of sulfamethoxazole and trimethoprim in wastewater treatment plant effluent显示文摘 | Christopher C R David T T William A A | 2011 | Water research2011，45，3： | 1 |
| 19 | A practical guide to wavelet analysis 显示文摘 | Christopher T Gilbert P C | 1998 | Bulletfn of the American Meteorological Society1998，，1： | 1 |
| 20 | Identification of DNAbinding motifs of the Mycobacterium tuberculosis PhoP/PhoRtwo-component signal transduction System显示文摘 | Mena C Christophe T Amine N | 2012 | Plos One2012，7，42： | 1 |
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