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| 1 | Differential effects of glutamate receptor antagonists on dorsal horn neurons responding to colorectal distension in a neonatal colon irritation rat model显示文摘AIM: To investigate and compare the effects of spinal D-(-)-2-amino-7-phosphonoheptanoic acid (AP-7) and 6-cyano-7-nitroquinoxaline-2,3-dione disodium (CNQX),two glutamate receptor antagonists, on the responses of dorsal horn neurons to colorectal distension (CRD) in adult rats exposed to neonatal colon irritation (CI).METHODS: Hypersensitive SD rats were generated by CI during postnatal days 8, 10 and 12. Experiments on adult rats were performed using extracellular single-unit recording. The effects of spinal application of AP-7 (0.001,0.01, 0.1, 1 mmoL) were tested on the CRD-evoked neuronal responses in 16 controls and 17 CI rats. The effects of CNQX (0.2, 2, 5, 10 μmoL) were also tested on the CRD-evoked responses of 17 controls and 18 CI neurons.RESULTS: (1) The average responses of lumbosacral neurons to all intensities of CRD in CI rats were significantly higher than those in control rats; (2) In control rats, AP-7 (0.01 mmoL) had no significant effect on the neuronal response to all intensities of CRD (20,40, 60, 80 mmHg); while AP-7 (0.1 mmoL) inhibited the neuronal response to 80-mmHg CRD. By contrast, in CI rats, AP-7 (0.01-1 mmoL) attenuated the CRD-evoked neuronal responses to all distention pressures in a dosedependent manner; (3) In control rats, CNQX (2 μmoL)had no significantly effect on the neuronal response to all intensities of CRD; however, CNQX (5 μmoL) significantly attenuated the responses to CRD in the 40-80 mmHg range. By contrast, CNQX (2-10 μmoL)significantly decreased the neuronal responses in CI rats to non-noxious and noxious CRD in a dose-dependent manner.CONCLUSION: Our results suggest that spinal N-methyl-D-aspartate (NMDA) and non-NMDA receptors may contribute to the processing of central sensitivity in a neonatal CI rat model, but they may play different roles in it. | Chun Lin Elie D Al-Chaer | 2005 | World Journal of Gastroenterology2005，11，41： | 7 |
| 2 | Development of aorta-to-right atrial fistula following closure of secundum atrial septal defect using the Amplatzer septal occluder显示文摘 | CHUN D S TURRENTINE M W MOUSTAPHA A | 2003 | Cathet Cardio vasc Interv2003，58，： | 1 |
| 3 | Didemnin B, the first marine compound entering clinical trials as an antineoplastic agent显示文摘 | Chun HG Davies B Hoth D | 1986 | Invest New Drugs1986，4，3： | 1 |
| 4 | Nanometre Diameter Fibres of Polymer Produced by Electrospinning 显示文摘 | RENEKER D H CHUN I | 1996 | Nanotechnology1996，7，3： | 1 |
| 5 | Selective removal of HzS from coke oven gas显示文摘 | Park D W Chun S W Jang J Y | 1998 | Catalysis Today1998，44，14： | 1 |
| 6 | Beaded nanofibers formed during electrospinning显示文摘 | Fong H Chun I Reneker D H | 1999 | Polymer1999，40，16： | 1 |
| 7 | Beaded nanofibers formed during electrospinning 显示文摘 | FONG H CHUN 1 RENEKER D H | 1999 | Polymer1999，40，： | 1 |
| 8 | The ganglia distributed monitoring systemz design, implementation, and experience显示文摘 | Massie M L Chun B N Culler D E | 2004 | Parallel Computing2004，30，7： | 1 |
| 9 | Selective oxidation of H2S in the presence of ammonia and water using Co304/Si02 catalyst显示文摘 | Chun S W Jang J Y Park D W | 1997 | Korean Journal of Chemical Engineering1997，14，3： | 1 |
| 10 | Architecture of the Scalable Communications Core ' s Network on Chip 显示文摘 | Llitzky D A Hoffman J D Chun A | 2007 | Micro IEEE2007，27，5： | 1 |
| 11 | Cyto-chrome P450 1B1 :a target for inhibition in anticarci-nogenesis strategies 显示文摘 | GUENGERICH F CHUN Y J KIM D | 2003 | Mutation Research2003，，： | 1 |
| 12 | Application of factorial design to accelerate identification of CHO growth factor requirements显示文摘 | Chun C Heineken K Szeto D | | 0，，01： | 1 |
| 13 | Quantification of latent tis- sue reservoirs and total body viral load in HIV-1 infection显示文摘 | Chun TW Carruth L Finzi D etal | 1997 | Nature1997，387，6629： | 1 |
| 14 | Using computer networking to facilitate the acquisition of interactive competence显示文摘 | Chun D | 1994 | System1994，22，1： | 1 |
| 15 | Thrce-dimensional metalorganic framework with (3,4) -connected net, synthesized from an ionic liquid medium 显示文摘 | Dybtsev D N Chun H Kim K | 2004 | Chem Commun2004，14，： | 1 |
| 16 | Intracorporeal lithotripsy with the holmium: YAG laser显示文摘 | Razvi H A Densteclt J D Chun S S | 1996 | J Urol1996，156，3： | 1 |
| 17 | Cloning and expression of interferon-α/γ from a domestic porcine breed and its effect on classical swine fever virus 显示文摘 | Chun X Wu D Wu W X | 2005 | Vet Immunol Immunopathol2005，104，： | 1 |
| 18 | The separated shorted-anode insulated gate bipolar transistor with the suppressed negative differential resistance regime 显示文摘 | BYEONA D S CHUN J H LEE B H | 1999 | Microelectronics Journal1999，30，6： | 1 |
| 19 | Removal of hydrogen sulfide contained in smelt-off-gas by selective oxidation over Co3 04/'SiO2 catalyst显示文摘 | Park D W Chun S W Park B K | 2001 | Journal of Chemical Engineering of Japan2001，34，2： | 1 |
| 20 | Enhancing the Government Service Experience through QR Codes on Mobile PLatforms显示文摘 | Lorenzi D Vaidya J Chun S | 2014 | Government Information Quarterly2014，31，1： | 1 |
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