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| 1 | Geochronology and petrogenesis of granitic rocks in Gangdese batholith, southern Tibet显示文摘Based on petrological and geochemical characteristics such as rock assemblage, petrogeochemistry, Sr-Nd isotope, zircon U-Pb age, and Hf isotope, we studied geochronological framework, magma types, source characters, and petrogenesis of different stages of magmatism of the granitic rocks from the Gangdese batholith in southern Tibet. The magmatic activities of the Gangdese batholith can be divided into three stages. The Mesozoic magmatism, induced by northern subduction of Neotethyan slab, was continuously developed, with two peak periods of Late Jurassic and Early Cretaceous. The Paleocene-Eocene magmatism was the most intensive, and resulted from a complex progress of Neotethyan oceanic slab, including subduction, rollback, and subsequent breakoff. And the Oligocene-Miocene magmatism was attributed to the convective removal of thickened lithosphere in an east-west extension setting after India-Asia collision. Isotopically, zircons from these granitic rocks are characterized by positive εHf(t) values, suggesting that the magmatic source of the Gangdese batholith might be an arc terrane, which was accreted to the southern margin of Asia during Late Paleozoic. Therefore, the chronological framework and Hf isotopic characteristics of the Gangdese batholith are distinct from the granitic rocks in adjacent areas, which can be served as a powerful tracer in studying source-to-sink relation of sediments during the uplift and erosion of Tibetan Plateau. | JI WeiQiang WU FuYuan LIU ChuanZhou CHUNG SunLin | 2009 | Science China Earth Sciences2009，52，9： | 89 |
| 2 | 克罗恩病:CT小肠成像、MR小肠成像和小肠灌肠造影的比较显示文摘目的前瞻性比较CT和MR小肠成像及小肠灌肠造影3种检查方法发现克罗恩病病人活动性小肠炎症和肠外并发症的准确性。方法机构伦理审查委员会批准本研究计划,并所有参与者知情同意。对连续31例克罗恩病或疑有克罗恩病的病人行CT和MR小肠成像、小肠灌肠造影和回肠结肠镜检查。2位独立的阅片者回顾CT和MR小肠成像及小肠灌肠造影影像以确定活动性末端回肠炎和肠道外并发症的存在。以回结肠镜检查结果作为参考标准,利用受试者工作特性曲线方法来评估CT和MR小肠成像及小肠灌肠造影确定活动性末端回肠炎的准确度。 | S.S. Lee A.Y. Kim S.K. Yang J. W. Chung S.Y. Kim S.H. Park 孙东辉(译) 万业达(校) | 2009 | 国际医学放射学杂志2009，32，4： | 57 |
| 3 | 香港华人妇女产后抑郁危险因素的前瞻性研究显示文摘目的:产后抑郁是一种常见的精神障碍,对产妇、新生儿和其它家庭成员导致广泛的伤害。产后抑郁的病因学研究大多是基于西方样本,对其中的社会文化原因也缺乏实证研究。本研究从人口学、心理社会及种族文化因素等方面探讨中国妇女产后抑郁症状学的决定因素。方法:在大学附属综合医院产前门诊连续收集登记的中国孕妇959例,从她们第一次产前检查开始评估(基线),以后分别在孕期的最后3个月、产后即刻和产后3个月时评估。调查涉及的危险因素分6个方面:人口学和社会经济背景,躯体疾病及精神疾病病史, 产前抑郁情绪,围生期应激源,人际关系,和种族文化环境。采用等级回归进行分析。因变量是产后3个月时的抑郁评分。结果:决定产后抑郁症状学的因素有:目前的生活事件,缺乏社会支持,婚姻不满意,既往有故意自伤史,以及产前存在抑郁情绪。婆媳关系不好和没有陪月在产后阶段也与抑郁评分高有关联。结论:西方研究所确立的产后抑郁危险因素大体适用于中国妇女。产褥期的社会文化特点同样对产妇情绪有影响。 | Dominic TS Lee Alexander SK Yip Sandra SM Chan Fiona FY Lee Tony YS Leung Tony KH Chung | 2005 | 中国心理卫生杂志2005，19，9： | 50 |
| 4 | Expression,purification and characterization of enterovirus-71 virus-like particles显示文摘瞄准:Enterovirus 71 (EV71 ) 作为为在亚太区域与严重神经病学的疾病联系的手,脚和嘴疾病的最近的爆发负责的病因学的代理人被含有。方法:集会过程被假设发生经由一由病毒的朊酶 3CD 的 P1 先锋的安排解朊的处理。测试这个假设,我们构造了 3 recombinant baculoviruses:表示 P1 的 Bac-P1;表示 3CD 的 Bac-3CD;并且 Bac-P1-3CD 共同表示 P1 和 3CD。结果:由 Bac-P1-3CD 的两单个感染和由 Bac-P1 和 Bac-3CD 的合作感染导致了 P1 的正确劈开产出单个蛋白质 VP0, VP1 和 VP3,当以前的途径产出更高的 VLP 生产时。在房间,进类似于真 EV71 粒子总数的像病毒的粒子(VLP ) 的簇自我装配的结构的蛋白质。在 ultracentrifugation 纯化以后,驱散的 VLP 与在尺寸,外观,作文和表面 epitopes 的真病毒难区分,作为由标记的 SDS 页,西方的污点,传播电子显微镜学和免疫黄金决定了。结论:我们的数据第一次,在 EV71 结构的蛋白质采用一个处理和类似于脊髓灰质炎病毒汇编的汇编小径的昆虫房间建议那。粒子形态学和作文的保藏建议 VLP 可以是一个珍贵疫苗的候选人阻止 EV71 流行病。 | Yao-Chi Chung Jen-Huang Huang Chia-Wei Lai Heng-Chun Sheng Shin-Ru Shih Mei-Shang Ho Yu-Chen Hu | 2006 | World Journal of Gastroenterology2006，12，6： | 42 |
| 5 | Calcium and Calmodulin-Mediated Regulation of Gene Expression in Plants显示文摘无柄的植物开发了一个很精细的系统由使用一个简单 Ca2+ 离子察觉到内长的发展暗示和外长的环境刺激的多样的类型。Calmodulin (凸轮) 是占优势的 Ca2+ 传感器并且在在优核质在各种各样的细胞的分隔空间译码 Ca2+ 签名进合适的细胞的回答起一个关键作用。证据的成长身体在对内长、外长的刺激的植物回答期间在 transcriptional 过程的规定指向 Ca2+ 和凸轮的重要性。这里,我们在 Ca2+ 和凸轮并且在对他们的功能的意义的评价响应关於生命、不能生活的压力和发展暗示在植物信号 transduction 期间调制的 transcriptional 管理者的鉴定考察最近的进步。 | Min Chul Kim Woo Sik Chung Dae-Jin Yun Moo Je Cho | 2009 | Molecular Plant2009，2，1： | 47 |
| 6 | Comparison of scoring systems in predicting the severity of acute pancreatitis显示文摘AIM:To investigate the prognostic usefulness of several existing scoring systems in predicting the severity of acute pancreatitis(AP).METHODS:We retrospectively analyzed the prospectively collected clinical database from consecutive patients with AP in our institution between January 2011 and December 2012.Ranson,Acute Physiology and Chronic Health Evaluation(APACHE)-Ⅱ,and bedside index for severity in acute pancreatitis(BISAP)scores,and computed tomography severity index(CTSI)of all patients were calculated.Serum C-reactive protein(CRP)levels were measured at admission(CRPi)and after 24h(CRP24).Severe AP was defined as persistent organ failure for more than 48 h.The predictive accuracy of each scoring system was measured by the area under the receiver-operating curve(AUC).RESULTS:Of 161 patients,21(13%)were classified as severe AP,and 3(1.9%)died.Statistically significant cutoff values for prediction of severe AP were Ranson≥3,BISAP≥2,APACHE-Ⅱ≥8,CTSI≥3,and CRP24≥21.4.AUCs for Ranson,BISAP,APACHE-Ⅱ,CTSI,and CRP24 in predicting severe AP were 0.69(95%CI:0.62-0.76),0.74(95%CI:0.66-0.80),0.78(95%CI:0.70-0.84),0.69(95%CI:0.61-0.76),and0.68(95%CI:0.57-0.78),respectively.APACHE-Ⅱdemonstrated the highest accuracy for prediction of severe AP,however,no statistically significant pairwise differences were observed between APACHE-Ⅱand the other scoring systems,including CRP24.CONCLUSION:Various scoring systems showed similar predictive accuracy for severity of AP.Unique models are needed in order to achieve further improvement of prognostic accuracy. | Joon Hyun Cho Tae Nyeun Kim Hyun Hee Chung Kook Hyun Kim | 2015 | World Journal of Gastroenterology2015，21，8： | 35 |
| 7 | Berberine induces cell cycle arrest and apoptosis in human gastric carcinoma SNU-5 cell line显示文摘瞄准:与它行动的分子的机制调查在小檗硷和 apoptotic 小径的禁止的生长(细胞毒素的活动) 之间的关系。方法:在试管内细胞毒素的技术被房间周期分析和 sub-G1 的决心在人的胃的癌 SNU-5 房间为 apoptosis 补充。可行房间,房间周期,和 sub-G1 组(apoptosis ) 的百分比被流动 cytometric 方法检验并且决定。为房间周期拘捕和 apoptosis 的联系蛋白质被西方的弄污检验。结果:为 SNU-5 房间线, IC50 被发现是小檗硷的 48 micromol/L。在与 25-200 micromol/L 小檗硷对待的 SNU-5 房间, G2/M 房间周期拘捕被观察它与 p53, Wee1 和 CDk1 蛋白质和减少的 cyclin 的表示的显著增长被联系 B。在 G0/G1 阶段的房间和 G2/M 阶段的增加的集中依赖者减少被检测。另外,当在房间周期测量的 sub-G0 房间人口被监视 apoptotic 小径在 25-200 micromol/L 证明对待 berberine 的房间, apoptosis 检测了。 Apoptosis 被 sub-G0 房间人口识别,并且在 Bcl-2 的规定下面,Ca2+在 Bax 的规定上面释放,减少 mitochondrial 膜电位然后导致了 mitochondrial 细胞色素 C 的版本进细胞质并且引起了 caspase-3 的激活,并且最后导致了 apoptosis 的出现。结论:小檗硷导致 p53 表示并且为 apoptosis 的正式就职导致 mitochondrial 膜电位,细胞色素 C 版本和 caspase-3 的激活的减少。 | Jing-Pin Lin Jai-Sing Yang Jau-Hong Lee Wen-Tsong Hsieh Jing-Gung Chung | 2006 | World Journal of Gastroenterology2006，12，1： | 34 |
| 8 | 8-Hydroxydeoxyguanosine:Not mere biomarker for oxidative stress,but remedy for oxidative stress-implicated gastrointestinal diseases显示文摘Reactive oxygen species (ROS) attack guanine bases in DNA easily and form 8-hydroxydeoxyguanosine (8-OHdG),which can bind to thymidine rather than cytosine,based on which,the level of 8-OHdG is gen-erally regarded as a biomarker of mutagenesis conse-quent to oxidative stress.For example,higher levels of 8-OHdG are noted in Helicobacter pylori-associated chronic atrophic gastritis as well as gastric cancer.However,we have found that exogenous 8-OHdG can paradoxically reduce ROS production,attenuate thenuclear factor-κB signaling pathway,and ameliorate the expression of proinflammatory mediators such as interleukin (IL)-1,IL-6,cyclo-oxygenase-2,and induc-ible nitric oxide synthase in addition to expression of nicotinamide adenine dinucleotide phosphate oxidase (NOX)-1,NOX organizer-1 and NOX activator-1 in vari-ous conditions of inflammation-based gastrointestinal (GI) diseases including gastritis,inflammatory bowel disease,pancreatitis,and even colitis-associated carci-nogenesis.Our recent finding that exogenous 8-OHdG was very effective in either inflammation-based or oxidative-stress-associated diseases of stress-related mucosal damage has inspired the hope that synthetic 8-OHdG can be a potential candidate for the treatment of inflammation-based GI diseases,as well as the pre-vention of inflammation-associated GI cancer.In this editorial review,the novel fact that exogenous 8-OHdG can be a functional molecule regulating oxidative-stress-induced gastritis through either antagonizing Rac-guanosine triphosphate binding or blocking the signals responsible for gastric inflammatory cascade is introduced. | Chan-Young Ock Eun-Hee Kim Duck Joo Choi Ho Jae Lee Ki-Baik Hahm Myung Hee Chung | 2012 | World Journal of Gastroenterology2012，18，4： | 30 |
| 9 | Fenton工艺深度处理垃圾渗滤液中难降解有机物显示文摘选用Fenton工艺对经过生化处理后的城市垃圾渗滤液进行深度处理.结果表明,该工艺具有氧化和混凝的双重作用,其最优工艺条件为:[H2O2]=38.8 mmol/L、[Fe2+]=30 mmol/L、初始pH为3、混凝pH为8,反应时间60 min,H2O2为一次投加.在此条件下,COD和TOC的去除率分别达63.43%和80.58%.同时分析了各种影响因子对Fenton试剂处理效果的作用机理. | 赵冰清 陈胜 孙德智 Jong Shik Chung | 2007 | 哈尔滨工业大学学报2007，39，8： | 28 |
| 10 | Analysis of demographic characteristics in 3242 young age gastric cancer patients in Korea显示文摘AIM:To evaluate the epidemiologic features of young age gastric cancer(GC). METHODS:Retrospectively,a total of 3242 patients with GC between 18 and 45 years of age and 3000 sex-and age-matched controls were reviewed.All subjects were stratified into 3 groups based on age (A,18-30 years;B,31-40 years;C,41-45 years). Epidemiologic characteristics and risk factors were investigated with reference to their age and gender. RESULTS:Compared to controls,more frequent intake of high risk diet(P=0.00075),history of heavy smoking(P=0.00087),intake of heavy alcohol(P= 0.00091),lower social economic status(P=0.00083), body mass index>30(P=0.00097),urban residence(P=0.00065),and more frequent exposure to harmful occupational environments(P=0.00072)were observed in all age groups and both genders in young age GC.These relationships were weaker in females compared to males of the same age,and were stronger as the age of patients increased.However,in group C of young age GC patients,environmental factors played important roles in females and males with a similar body weight.In females,older age at first delivery(> 35 years),lack of lactation history,nulliparity,and poor nutritional status during pregnancy were significantly associated with an increased risk of GC(P=0.00034). In this study,252 patients(7.8%)had a family history of GC with high odds ratio(OR)(3.22-4.21).In particular, family history was more closely associated with GC in males(OR,4.21 in male vs 3.46 in female)and more advanced cases(P=0.00051). CONCLUSION:Hormonal associated factors were more commonly associated with females whereas environmental factors were more commonly associated with males in young age GC patients. | Hye Won Chung Sung Hoon Noh Jong-Baeck Lim | 2010 | World Journal of Gastroenterology2010，16，2： | 26 |
| 11 | 茶黄素双没食子酸酯的抗癌活性及其作用机理研究显示文摘以SephadexLH-20柱色谱分离得到茶黄素双没食子酸酯(TFDG)成分,以H1299和HCT-116细胞分析了该成分的抗癌活性及其作用机理。结果表明,TFDG具有良好的抑制H1299细胞生长的活性,IC50为25μmol/L;有调节细胞周期的活性,可增加HCT-116细胞G1期细胞的比例;有促进HCT-116细胞凋亡的作用,浓度为50μmol/L时效果显著,48h凋亡率达到40%以上;Western杂交技术分析结果表明,它可降低HCT-116细胞中促癌蛋白质因子Bcl-xL的表达量,可增加抑癌蛋白质因子Bax的表达量。 | 江和源 Hang Xiao 袁新跃 王川丕 Chung S Yang | 2007 | 茶叶科学2007，27，1： | 25 |
| 12 | 乙二醇中化学还原合成片状银粉显示文摘研究了乙二醇(EG)介质中以聚乙烯吡咯烷酮(PVP)为保护剂,以氯铂酸为催化剂以硝酸银为前驱物经化学还原制备片状银粉的过程,探索与分析影响银粉形貌的主要因素.结果表明,首先被还原出来的铂成为外来晶种,是形成片状银的关键因素.它在原位为随后还原与沉淀的银提供一个平面.PVP与银离子形成络合离子,控制游离银离子的浓度,影响银的成核与生长.同时,PVP被选择性地吸附于银的粒子表面,影响了银成核与生长,最终形成片状银粉. | 梁焕珍 Kim Dong-Jin Chung Hun S. 张洁 喻克宁 黎少华 李锐星 | 2003 | 物理化学学报2003，19，2： | 26 |
| 13 | Recent Advances in Cuticular Wax Biosynthesis and Its Regulation in Arabidopsis显示文摘The aerial parts of land plants are covered with cuticular waxes that limit non-stomatal water loss and gaseous exchanges,and protect plants from ultraviolet radiation and pathogen attacks.They are composed of very-long-chain fatty acids (VLCFAs;C20 to C34) in addition to their derivatives,aldehydes,alkanes,primary and secondary alcohols,and wax esters.Due to their physical properties,such as solidity at room temperature and a translucency ranging from transparent to opaque,plant waxes have been used as raw materials in the production of cosmetics,detergents,plastics,soaps,paints,drugs,lubricants,and high-value renewable fuels.Many genes involved in cuticular wax biosynthesis and export have been characterized by forward and reverse genetic approaches as well as by stem epidermis transcriptome analysis.The regulatory mechanisms of cuticular wax biosynthesis have been reported at the transcriptional,posttranscriptional,and translational levels.Recent advances in cuticular wax biosynthesis and its regulation are reviewed in this paper. | Saet Buyl Lee Mi Chung Suh | 2013 | Molecular Plant2013，6，2： | 24 |
| 14 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 15 | Lepidium meyenii (Maca) improved semen parameters in adult men显示文摘Aim: The present study was designed to determine the effect of a 4-month oral treatment with tablets of Lepidium meyenii (Maca) on seminal analysis in nine adult normal men aged 24 - 44 years old. Methods: Nine men received tablets of Maca (1500 or 3000 mg/day) for 4 months. Seminal analysis was performed according to guidelines of the World Health Organization (WHO). Serum luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), testosterone (T) and estradiol (E2) were measured before and after treatment. Results: Treatment with Maca resulted in increased seminal volume, sperm count per ejaculum, motile sperm count, and sperm motility. Serum hormone levels were not modified with Maca treatment. Increase of sperm count was not related to dose of Maca.Conclusion: Maca improved sperm production and sperm motility by mechanisms not related to LH, FSH, PRL, T and E2 . | Gustavo F.Gonzales Amanda Cordova Carla Gonzales Arturo Chung Karla Vega Arturo Villena | 2001 | Asian Journal of Andrology2001，3，4： | 23 |
| 16 | Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells显示文摘AIM: The genes were divided into seven categories according to biological function; apoptosis-reiated, immune response-related, signal transduction-related, cell cyclerelated, cell growth-related, stress response-related and transcription-related genes.METHODS: We compared the gene expression profiles of SNU-C4 cells between amygdalin-treated (5 mg/mL,24 h) and non-treated groups using cDNA microarray analysis. We selected genes downregulated in cDNA microarray and investigated mRNA levels of the genes by RT-PCR. RESULTS: Microarray showed that amygdalin downregulated especially genes belonging to cell cycle category: exonuclease 1 (EXO1), ATP-binding cassette, sub-family F, member 2 (ABCF2), MRE11 meiotic recombination 11 homolog A (MRE114), topoisomerase (DNA) I (TOP1), and FK506 binding protein 12-rapamycin-associated protein 1 (FRAP1). RT-PCR analysis revealed that mRNA levels of these genes were also decreased by amygdalin treatment in SNU-C4 human colon cancer cells.CONCLUSION: These results suggest that amygdalin have an anticancer effect via downregulation of cell cycle-related genes in SNU-C4 human colon cancer cells,and might be used for therapeutic anticancer drug. | Hae-Jeong Park Seo-Hyun Yoon Long-Shan Han Long-Tai Zheng Kyung-Hee Jung Yoon-Kyung Uhm Je-Hyun Lee Ji-Seon Jeong Woo-Sang Joo Sung-Vin Yim Joo-Ho Chung Seon-Pyo Hong | 2005 | World Journal of Gastroenterology2005，11，33： | 23 |
| 17 | Estimating liver weight of adults by body weight and gender显示文摘瞄准:为了为估计接枝的足够估计标准肝重量,为癌症在主要肝切除术在实时施主肝移植和残余肝缩放。方法:在这研究,体重和身高的人体测量的数据在 159 个实时的肝施主为与肝重量的关联被测试包括中间的肝的静脉经历了施主权利肝切除术。肝重量从在背表格获得的正确脑叶接枝重量被计算,在计算断层摄影术上由正确脑叶的比例划分了。结果:这些题目,所有汉语,有 35.8+/-10.5 年,和女性的吝啬的年龄到 118:41 的男比率。正确脑叶的吝啬的体积是 710.14+/-131.46 mL 并且在计算断层摄影术上占据了整个肝的 64.55%+/-4.47% 。正确脑叶称了 598.90+/-117.39 g,估计的肝重量是 927.54+/-168.78 g。当体重和身高受到多重逐步的线性回归分析时,身高被发现不足道。一样的体重的女性有稍微更低的肝重量。一个公式基于体重和性被导出:估计的标准肝重量(g)= 218 + BW (kg ) x 12.3 + 性 x 51 (R2 = 0.48 )( 女 = 0,男 = 1 ) 。基于这 159 个题目,的人体测量的数据肝重量用在白种人,日语,朝鲜语,和汉语上从研究导出的以前出版的公式被计算。所有公式与这个公式相比过高估计肝重量。日本公式为成年人过高估计估计的标准肝重量(ESLW ) 不到 60 kg。结论:对中国男性和女性适用的一个公式是可得到的。为单个赛跑的一个公式显得必要。 | See Ching Chan Chi Leung Liu Chung Mau Lo Banny K Lam Evelyn W Lee Yik Wong Sheung Tat Fan | 2006 | World Journal of Gastroenterology2006，12，14： | 22 |
| 18 | Diverse Functions of VDUP1 in Cell Proliferation,Differentiation,and Diseases显示文摘Vitamin D3 up-regulated protein 1 (VDUP1) is a multifunctional protein involved in maintaining cellular homeostasis. VDUP1 is induced by a variety of stresses. Inversely,VDUP1 is often reduced in various tumor tissues and cell lines. Over-expression of VDUP1 inhibits cell proliferation through cell cycle arrest. VDUP1 interacts with thioredoxin (Trx) and negatively regulates the expression and antioxidant function of Trx which is involved in redox regulation. VDUP1-/-mice are more susceptible to carcinogenesis than wild-type mice and are defective in establishing immune system including the development and function of natural killer cells. Furthermore,VDUP1-/-mice show impaired Kreb cycle-mediated fatty acid utilization. In this review,we have discussed the multifunctional roles of VDUP1 in diverse cellular responses,in particular its relation to proliferation,apoptosis,differentiation,and diseases such as cancer and stress-related diseases. | Sang Yong Kim Hyun-Woo Suh Jin Woong Chung Suk-Ran Yoon Inpyo Choi | 2007 | Cellular & Molecular Immunology2007，4，5： | 22 |
| 19 | The CONSTANS-like 4 transcription factor,AtCOL_4,positively regulates abiotic stress tolerance through an abscisic acid-dependent manner in Arabidopsis显示文摘The precise roles of the B-box zinc finger family of transcription factors in plant stress are poorly understood.Functional analysis was performed on AtCOL4,an Arabidopsis thaliana L.CONSTANS-like 4 protein that is a putative novel transcription factor,and which contains a predicted transcriptional activation domain.Analyses of an AtCOL4 promoter-b-glucuronidase(GUS) construct revealed substantial GUS activity in whole seedlings.The expression of AtCOL4 was strongly induced by abscisic acid(ABA),salt,and osmotic stress.Mutation in atcol4 resulted in increased sensitivity to ABA and salt stress during seed germination and the cotyledon greening process.In contrast,AtCOL4-overexpressing plants were less sensitive to ABA and salt stress compared to the wild type.Interestingly,in the presence of ABA or salt stress,the transcript levels of other ABA biosynthesis and stress-related genes were enhanced induction in AtCOL4-overexpressing and WT plants,rather than in the atcol4 mutant.Thus,AtCOL4 is involved in ABA and salt stress response through the ABA-dependent signaling pathway.Taken together,these findings provide compelling evidence that AtCOL4 is an important regulator for plant tolerance to abiotic stress. | Ji-Hee Min Jung-Sung Chung Kyeong-Hwan Lee Cheol Soo Kim | 2015 | Journal of Integrative Plant Biology2015，57，3： | 23 |
| 20 | Role of the tumor microenvironment in the pathogenesis of gastric carcinoma显示文摘Gastric carcinoma(GC)is the 4thmost prevalent cancer and has the 2ndhighest cancer-related mortality rate worldwide.Despite the incidence of GC has decreased over the past few decades,it is still a serious health problem.Chronic inflammatory status of the stomach,caused by the infection of Helicobacter pylori(H.pylori)and through the production of inflammatory mediators within the parenchyma is suspected to play an important role in the initiation and progression of GC.In this review,the correlation between chronic inflammation and H.pylori infection as an important factor for the development of GC will be discussed.Major components,including tumor-associated macrophages,lymphocytes,cancer-associated fibroblasts,angiogenic factors,cytokines,and chemokines of GC microenvironment and their mechanism of action on signaling pathways will also be discussed.Increasing our understanding of how the components of the tumor microenviroment interact with GC cells and the signaling pathways involved could help identify new therapeutic and chemopreventive targets. | Hye Won Chung Jong-Baeck Lim | 2014 | World Journal of Gastroenterology2014，20，7： | 23 |
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