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| 1 | Reduction of Cancer Risk With an Oral Supplement of Selenium显示文摘The hypothesis that a dietary Supplement of selenium (Se) may reduce cancer risk was tested experimetally in humans. Patients with histories of basal/squarnous cell carcinomas of the skin were assigned randomly in double-blind fashion to dally oral supplements of either Seenriched yeast (200 μg Se/day), or a low-Se yeast placebo. A total of 1312 patients recruited in 1983-1990 were followed with regular dermatologic examinations through 1993 for a total of 8269 person-years of observation. Skin cancer diagnoses were confirmed histologically.Plasma Se concentration was determined at 6-12 months intervals. All deaths and patient-reported illnesses were recorded; reported cancers were confirmed and documented by consultation with the patient medical care providers. The results indicate that Se did not significantly affect the primary endpoints: incidences of recurrent basal/squarnous cell carcinomas of the skin. However, Setreatment was associated with reductions in several secondary endpoints:total mortality, mortality from all cancers combined, as well as the incidence of all cancers combined, lung cancer, colorectal cancer and prostate cancer. The consistencies of these associations over time, between study clinics and for the leading cancer sltes strongly suggests benefits of Se-supplementation for this cohort of patients, supporting the hypopthesis that supplemental Se can reduce cancer risk. Although Se did no shown protective effects against nonmelanoma skin cancers, the suggested reductions in risks to other frequent cancers demand further evaluation in well controlled cliflical intervention | G·F·COMBSJR L·C·CLARK 等 | 1997 | Biomedical and Environmental Sciences1997，10，2： | 21 |
| 2 | Restoring de novo coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous coenzyme Q supplementation显示文摘 | Gomez F Saiki R Chin R Srinivasan C Clarke CF | 2012 | Gene2012，506，： | 1 |
| 3 | Distance to nearest neighbor as a measure of spatial relationships in populations显示文摘 | Clark P J Evans F C | 1954 | Ecology1954，35，4： | 1 |
| 4 | Transient expression and insertional mutagenesis of Puccinia triticina using biolistics显示文摘 | CRAIG A W LES J S GUUS B CLARKE G RICHARD C S MERLE E JOHN P F | 2005 | Functional & Integrative Genomics2005，12，： | 1 |
| 5 | Distance to nearest neighbor as measure of spatial relationships in populations 显示文摘 | Clark P J Evans F C | 1954 | Ecology1954，35，： | 1 |
| 6 | Distance to nearest neighbor as a measure ofspatial relationships in populations显示文摘 | Clark P J Evans F C | 1954 | Ecology1954，35，4： | 1 |
| 7 | Safety, immunogenicity and efficacy in healthy infants of G1 and G2 human reassortant rotavirus vaccine in a new stabilizer/buffer liquid formulation显示文摘 | Clark H F Burke C J Volkin D B | 2003 | Pediatr Infect Dis J2003，22，10： | 1 |
| 8 | Distance to nearest neighbor as a mea- sure of spatial relationships in populations显示文摘 | Clark P J Evans F C | 1954 | Ecology1954，35，4： | 1 |
| 9 | Survival of mammals breathing organic liquids equilibrated with oxygen at atmospheric pressure显示文摘 | Clark L C Jr Gollan F | 1966 | Science1966，152，3730： | 1 |
| 10 | Distance to nearest neighbour as a measure of spatial relationships in populations 显示文摘 | CLARK P J EVANS F C | 1954 | Ecology1954，35，： | 1 |
| 11 | Detection in escherichia coli of the genes encoding the major virulence factors, the genes defining the O157 : H7 serotype, and components of the type 2 shiga toxin family by multiplex PCR 显示文摘 | WANG G H CLARK C G RODGERS F G | 2002 | Journal of Applied Microbiology2002，40，10： | 1 |
| 12 | Identification of QTL and association of a phytoene synthase gene with endosperm color in durum wheat显示文摘 | Pozniak C J Knox R E Clarke F R | 2007 | Theor Appl Gene2007，114，： | 1 |
| 13 | Hardware for digitally controlled scanned probe microscopes显示文摘 | Clark S M Baselt D R Spence C F | 1992 | Review of Scientific Instruments1992，10，： | 1 |
| 14 | Electrically conductive geosynthetics for consolidation and reinforced soil 显示文摘 | HAMIR R B JONES C J F P CLARKE B G | 2001 | Geotextiles and Geomembranes2001，19，8： | 1 |
| 15 | Facts and recommendations about total homocysteine determinations:an expert opinion显示文摘 | Refsum H Smith A D Ueland P M Nexo E Clarke R McPartlinJ Johnston C Engbaek F SchneedeJ McPartlin C Scott J M | 2004 | Clinical Chemistry2004，50，1： | 1 |
| 16 | RECK--a newly discovered inhibitor of metastasis with prognostic significance in multiple forms of cancer显示文摘 | CLARK J C THOMAS D M CHOONG P F | 2007 | Cancer Metastasis Rev2007，26，： | 1 |
| 17 | A General-purpose Parallel Raster Processing Programming Library Test Ap- plication Using a Geographic Cellular Automata Model显示文摘 | Guan Q F Clarke K C | 2010 | International Journal of Geographical In- formation Science2010，24，5： | 1 |
| 18 | Distance to nearest neighbor as a measure of spatial relationships in populations显示文摘 | Clark P J Evans F C | 1954 | Ecology1954，35，4： | 1 |
| 19 | Peripheral CD4 loss of regulatory T cells is associated with persistent viraemia in chronic HIV infection显示文摘 | Baker C A Clark R Ventura F | 2007 | Clin Exp Immunol2007，147，： | 1 |
| 20 | Effective force testing: A method of seismic simulation for structural testing 显示文摘 | Dimig J Shield C French C Bailey F Clark A | 1999 | Journal of Structural Engineering1999，125，9： | 1 |
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