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| 1 | Reduction of Cancer Risk With an Oral Supplement of Selenium显示文摘The hypothesis that a dietary Supplement of selenium (Se) may reduce cancer risk was tested experimetally in humans. Patients with histories of basal/squarnous cell carcinomas of the skin were assigned randomly in double-blind fashion to dally oral supplements of either Seenriched yeast (200 μg Se/day), or a low-Se yeast placebo. A total of 1312 patients recruited in 1983-1990 were followed with regular dermatologic examinations through 1993 for a total of 8269 person-years of observation. Skin cancer diagnoses were confirmed histologically.Plasma Se concentration was determined at 6-12 months intervals. All deaths and patient-reported illnesses were recorded; reported cancers were confirmed and documented by consultation with the patient medical care providers. The results indicate that Se did not significantly affect the primary endpoints: incidences of recurrent basal/squarnous cell carcinomas of the skin. However, Setreatment was associated with reductions in several secondary endpoints:total mortality, mortality from all cancers combined, as well as the incidence of all cancers combined, lung cancer, colorectal cancer and prostate cancer. The consistencies of these associations over time, between study clinics and for the leading cancer sltes strongly suggests benefits of Se-supplementation for this cohort of patients, supporting the hypopthesis that supplemental Se can reduce cancer risk. Although Se did no shown protective effects against nonmelanoma skin cancers, the suggested reductions in risks to other frequent cancers demand further evaluation in well controlled cliflical intervention | G·F·COMBSJR L·C·CLARK 等 | 1997 | Biomedical and Environmental Sciences1997，10，2： | 21 |
| 2 | Lipidomic analysis of the molecular specificity of a cholinephosphotransferase in situ显示文摘 | FENN H C CLARK G T | 2004 | Biochem Soc Trans2004，32，6： | 1 |
| 3 | A Dynamic Model for Predicting Fouling Effects During the Uhrafihration of a Groundwater 显示文摘 | Wetterau G E Clark M M Anselme C | 1996 | Journal of Membrane Science1996，109，： | 1 |
| 4 | Micrometastases in esophagogastric cancer:high detection rate in resected rib segments显示文摘 | O'SULLIVAN G C SHEEHAN D CLARKE A | 1999 | Gastroenterology1999，116，3： | 1 |
| 5 | Icthyophthirius muhifiliis has membrane-associated immobilization antigens显示文摘 | Dickerson H W Clark T G Findly R C | 1989 | J Protozool1989，36，2： | 1 |
| 6 | Transient expression and insertional mutagenesis of Puccinia triticina using biolistics显示文摘 | CRAIG A W LES J S GUUS B CLARKE G RICHARD C S MERLE E JOHN P F | 2005 | Functional & Integrative Genomics2005，12，： | 1 |
| 7 | Genomic instability at the Bub1 locus in colorectal cancer,but not in non-small cell lung cancer显示文摘 | JAFFREY R G PRITCHARD S C CLARK C | 2000 | Cancer Res2000，60，9： | 1 |
| 8 | Evaluation of the antidiabetic activity of DPP Ⅳ resistant N-terminally modified versus mid-chain acylated analogues of glucose-dependent insulinotropic polypeptide显示文摘 | IRWIN N CLARKE G C GREEN B D | 2006 | Biochem Pharmacol2006，72，6： | 1 |
| 9 | Existing knowledge,knowledge creation capability,and the rate of new product introduction in high-technology firms显示文摘 | Smith K G Collins C J Clark K D | | 0，，02： | 1 |
| 10 | Porcine postweaning multisystemic wasting syndrome in Korean pig:Detection of porcine circovirus 2 infection by immunohistochemistry and polymerase chain reaction显示文摘 | CHOI C CHAE C CLARK E G | 2000 | J Vet Diagn Invest2000，12，2： | 1 |
| 11 | Microbiologicai and epidemiological investigation of cholera epidemic in Ukraine during 1994 and 1995显示文摘 | CLARK C G KRAVETZ A N ALEKSEENKO V V | 1998 | Epidemiol Infect1998，121，1： | 1 |
| 12 | Three cases of neonatal meningitis caused by Enterobacter sakazakii in powdered milk显示文摘 | BIERING G KARLSSON S CLARK N V C | 1989 | Journal of Clinical Microbiology1989，27，9： | 1 |
| 13 | Detection in escherichia coli of the genes encoding the major virulence factors, the genes defining the O157 : H7 serotype, and components of the type 2 shiga toxin family by multiplex PCR 显示文摘 | WANG G H CLARK C G RODGERS F G | 2002 | Journal of Applied Microbiology2002，40，10： | 1 |
| 14 | amifositine reduces side effects and improves complete response rale during radiotherapy:esults sf meta-analysis显示文摘 | Sasse A D Clark L G Sasse E C | 2006 | Int J Radiat Oncol Biol Phys2006，64，3： | 1 |
| 15 | Historical surface faulting in the basin and range province,western North America: implications for fault segmentation 显示文摘 | DePolo C M Clark D G Slemmons D B | 1991 | J Struct Geol1991，13，： | 1 |
| 16 | Recognizing and diagnosing postweaning multisystemic wasting syndrome (PMWS)显示文摘 | HARDING J C S CLARK E G | 1997 | Swine Health and Production1997，5，： | 1 |
| 17 | Electrically conductive geosynthetics for consolidation and reinforced soil 显示文摘 | HAMIR R B JONES C J F P CLARKE B G | 2001 | Geotextiles and Geomembranes2001，19，8： | 1 |
| 18 | Existing knowledge, knowledge creation capability, and the rate of new product introduction in high-technology firms 显示文摘 | Smith K G Collins C J Clark K D | 2005 | Academy of Management Journal2005，48，2： | 1 |
| 19 | Effect of reduced water table and fertilizer levels on subirrigated tomato production显示文摘 | Stanley C D Clark G A | 2001 | Applied En- gineering in Agriculture2001，11，3： | 1 |
| 20 | Ropivacaine:a preliminary clinical trial显示文摘 | Bannister J Clark C Littlewood D G | 1989 | Br J Anaesth1989，63，： | 1 |
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