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| 1 | Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes显示文摘This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients. Better understanding of the risk factors and symptoms associated with this disease is essential to inform both health professionals and the general population of potential preventive and/or early detection measures. The identification of high-risk patients who could benefit from screening to detect pre-malignant conditions such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms is urgently required, however an acceptable screening test has yet to be identified. The management of pancreatic adenocarcinoma is evolving, with the introduction of new surgical techniques and medical therapies such as laparoscopic techniques and neo-adjuvant chemoradiotherapy, however this has only led to modest improvements in outcomes. The identification of novel biomarkers is desirable to move towards a precision medicine era, where pancreatic cancer therapy can be tailored to the individual patient, while unnecessary treatments that have negative consequences on quality of life could be prevented for others. Research efforts must also focus on the development of new agents and delivery systems. Overall, considerable progress is required to reduce the burden associated with pancreatic cancer. Recent, renewed efforts to fund large consortia and research into pancreatic adenocarcinoma are welcomed, but further streams will be necessary to facilitate the momentum needed to bring breakthroughs seen for other cancer sites. | Andrew McGuigan Paul Kelly Richard C Turkington Claire Jones Helen G Coleman R Stephen McCain | 2018 | World Journal of Gastroenterology2018，24，43： | 140 |
| 2 | Current practices and future prospects for the management of gallbladder polyps: A topical review显示文摘A gallbladder polyp is an elevation of the gallbladder mucosa that protrudes into the gallbladder lumen. Gallbladder polyps have an estimated prevalence in adults of between 0.3%-12.3%. However, only 5% of polyps are considered to be 'true' gallbladder polyps, meaning that they are malignant or have malignant potential. The main radiological modality used for diagnosing and surveilling gallbladder polyps is transabdominal ultrasonography. However, evidence shows that other modalities such as endoscopic ultrasound may improve diagnostic accuracy. These are discussed in turn during the course of this review. Current guidelines recommend cholecystectomy for gallbladder polyps sized 10 mm and greater, although this threshold is lowered when other risk factors are identified. The evidence behind this practice is relatively low quality. This review identifies current gaps in the available evidence and highlights the necessity for further research to enable better decision making regarding which patients should undergo cholecystectomy, and/or radiological follow-up. | R Stephen McCain Anna Diamond Claire Jones Helen G Coleman | 2018 | World Journal of Gastroenterology2018，24，26： | 25 |
| 3 | Hepatic failure caused by plasma cell infiltration in multiple myeloma显示文摘Although plasma cell infiltration is not rare in autopsy of patients with multiple myeloma (MM), it is very rarely detected in living patients. This is because MM rarely causes significant liver dysfunction that requires further evaluation. A 49-year-old man presented with acute renal failure and was diagnosed with kappa light chain MM stage B.Thalidomide and dexamethasone were initiated.The patient developed a continuous increase in bilirubin that led to severe cholestasis.A liver biopsy revealed plasma cell infiltration.He then rapidly progressed to liver failure and died.Treatment options are limited in MM with significant liver dysfunction.espite new drug therapies in MM,those patients with rapidly progressive liver failure appear to have a dismal outcome. | Fadi E Rahhal Robert R Schade Asha Nayak Teresa A Coleman | 2009 | World Journal of Gastroenterology2009，15，16： | 2 |
| 4 | Otolith-fish size relationship in juvenile gag (Mycteroperca microlepis ) of the eastern Gulf of Mexico : a comparison of growth rates between laboratory and field populations 显示文摘 | Strelcheck A J Fitzhugh G R Coleman F C | 2003 | Fish Res2003，60，： | 1 |
| 5 | Tissue angiotensin-converting-enzyme(ACE) deficiency leads to a reduction in oxidative stress and in atherosclerosis:studies in ACE-knockout mice type 2显示文摘 | Hayek T Pavlotzky E Hamoud S Coleman R Keidar S Aviram M | 2003 | Arterioscler Thromb Vasc Biol2003，23，： | 1 |
| 6 | 显示文摘 | Coleman H M Chiang K Amal R | 2005 | Chemical Engineering Journal2005，113，1： | 1 |
| 7 | Pomegranate phenol- ics from the peels, arils, and flowers are antiatherogenic: stud- ies in vivo in atherosclerotic apolipophages and e-deficient (E0) mice and in vitro in cultured macrophages and lipoproteins显示文摘 | Aviram M Volkova N Coleman R et a l | 2008 | Agric Food Chem2008，56，3： | 1 |
| 8 | Prospective multicenter study of axillary nodal staging by positron emission tomography in breast cancer:a report of the staging breast cancerwith PET Study Group显示文摘 | Wahl R L Siegel B A Coleman R E | | 0，，02： | 1 |
| 9 | A methodology for the as- sessment of unconventional(continuous) resources with an ap- plication to the Greater Natural Buttes Gas Field, Utah显示文摘 | Olea R A Cook T A Coleman J L | 2010 | Natural Resources Research2010，19，4： | 1 |
| 10 | Latest re- search and treatment of advanced-stage epithelial ovarian cancer显示文摘 | Coleman R L Monk B J Sood A K | 2013 | Nat Rev Clin Oneol2013，10，4： | 1 |
| 11 | Enzymes of triacylglycerol synthesis and their regulation 显示文摘 | Coleman R Lee D | 2004 | Progr Lipid Res2004，43，2： | 1 |
| 12 | Giant mitochondria inthe myocardium of aging and endurance-trained mice显示文摘 | Coleman R Sibermann M Gershon D | 1987 | Gerontology1987，33，1： | 1 |
| 13 | Muscle recovery after immobilisation by external fixation显示文摘 | Zarzhevsky N Coleman R Volpin G | 1999 | J Bone Joint Surg Br1999，81，5： | 1 |
| 14 | Effects of nitrogen and phosphorus on blue grama growth and mycorrhizal infection 显示文摘 | Hays R Reid C C P John T V St Coleman D C | 1982 | Oecologia1982，54，： | 1 |
| 15 | Metastatic bone disease: clinical features, pathophysiology and treatment strategies显示文摘 | Coleman R E | 2001 | Cancer Treat Rev2001，27，： | 1 |
| 16 | Initial clinical experience with the Ahmed glaucoma valve implant 显示文摘 | Coleman AL Hill R W' flson MR | 1995 | Am J Ophthalmol1995，120，1： | 1 |
| 17 | Initial clinical experience with the Ahmed glaucoma valve implant显示文摘 | Coleman AL Hill R Wilson MR | 1995 | Am J Ophthalmol1995，120，1： | 1 |
| 18 | In vitro cytokineprimed leukemia cells induce in vivo T cell responsiveness in chronic myeloid leukemia 显示文摘 | Lim SH Coleman S Bailey-Wood R | 1998 | Bone Marrow Transplant1998，22，12： | 1 |
| 19 | Bisphosphonates: clinical experience显示文摘 | Coleman R E | 2004 | Oncologist2004，9，4： | 1 |
| 20 | Physiologic concentrations of glucose regulate fatty acid synthase activity in HepG2 cells by mediating fatty acid synthase mRNA stability显示文摘 | Semenkovich CF Coleman T Groforth R | 1993 | Biol Chem1993，268，10： | 1 |
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