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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | 干扰素调节因子5通过损伤胞葬作用控制动脉粥样硬化病变中的坏死核心形成显示文摘髓系细胞是动脉粥样硬化病变发展和易损斑块形成的核心。动脉吞噬细胞吸收凋亡细胞(胞葬作用)的能力受损,可促进病变生长并建立坏死核心。干扰素调节因子(interferon regulatory factor,IRF)5是髓系细胞功能的重要调节因子。该研究试图确定IRF5是否影响动脉粥样硬化病变的形成和表型。方法:通过两种互补模型,研究IRF5在动脉粥样硬化中的作用: | Seneviratne AN Edsfeldt AO Cole JE Kassiteridi C Swart M Park I Green P Khoyratty TE Saliba DG Goddard ME Sansom SN Goncalves I Krams R Udalova IA Monaco C 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，8： | 9 |
| 3 | Molecular genetics and pathogenesis of Clostridium perfringens 显示文摘 | COLE S T | 1991 | Microbiol Rev1991，55，： | 1 |
| 4 | Novel bronsted acidic ionic liquids and their use as dual solvent-catalysts显示文摘 | Cole A C Jensen J L Ntai I | 2002 | Journal of the American Chemical Society2002，124，21： | 1 |
| 5 | Temperature-humidity indices as indicators of milk p roduction losses due to heat stres s显示文摘 | Bohmanova J Misztal I Cole J B | 2007 | J Dairy Sci2007，90，： | 1 |
| 6 | Preliminary experience with high-volume hemofiltration in human septic shock显示文摘 | Bellomo R Baldwin I Cole L | 1998 | Kidney Inter1998，53，166： | 1 |
| 7 | 查看详情显示文摘 | Cole A C Jensen J L Ntai I Tran K L T Weaver K J Forbes D C Davis J H Jr | | 0，，： | 1 |
| 8 | A formulation for determining the single-pass mechanics of the continuous four-roll thin plate bending process 显示文摘 | HUA M COLE I M BAINESS K | 1997 | Journal of Materials Processing Technology1997，67，： | 1 |
| 9 | Simulation of phosphorus cycling in semi-arid grassland显示文摘 | Cole C V Innis G I Stewart J W B | 1977 | Ecology1977，58，： | 1 |
| 10 | Preliminary experience with high2 volume hemofilt ration in human septic shock 显示文摘 | Bellomo R Baldwin I Cole L | 1998 | Kidney Int1998，，： | 1 |
| 11 | Novel Bronsted acidic ionic liquids and their use as dual solvent-catalysts显示文摘 | COLE A C JENSEN J L NTAI I | 2002 | Journal of the American Chemical Society2002，124，21： | 1 |
| 12 | Bending mechanicsms, experimental techniques and preliminary tests for the continuous four-roll plate bending process 显示文摘 | HUA M BAINESS K COLE I M | 1995 | Journal of Materials Processing Technology1995，48，： | 1 |
| 13 | J Am Chem Soc显示文摘 | Cole A C Jensen J L Ntai I | 2002 | 124:5962-59632002，124，： | 1 |
| 14 | Field performance of two peanut cultivars relative to aflatoxin contamination显示文摘 | Davidson J I Hill R A Cole R J | 1983 | Peanut Science1983，10，1： | 1 |
| 15 | Novel brφnsted acidic ionic liquids and their use as dual solvent-catalysts 显示文摘 | Cole A C Jensen J L Ntai I | 2002 | J Am Chem Soc2002，124，： | 1 |
| 16 | Predicting diatom communities at the genus level for therapid bioligical assessment of rivers显示文摘 | Chessman B Growns I Currey J Plunkett Cole N | 1999 | Freshwater Biology1999，41，2： | 1 |
| 17 | Novel Brφnsted Acidic Ionic Liquids and Their use as Dual Solvent-catalysts显示文摘 | Cole A C Jensen J L Ntai I | 2002 | J Am Chem Soc2002，124，59： | 1 |
| 18 | The initial mechanism of corrosion of zinc by sodium chloride particle deposition显示文摘 | NEUFELD A K COLE I S BOND A M FURMAN S A | 2002 | Corrosion Science2002，44，： | 1 |
| 19 | Novel Br6nsted Acidic Ionic Liquids and Their Use as Dual Solvent-Catalysts显示文摘 | Cole A C Jensen J L Ntai I | 2002 | J Am Chem Soc2002，124，21： | 1 |
| 20 | Leg lengthening over an intramedullary nail显示文摘 | Simpson AH Cole AS Kenwright I | 1999 | J Bone Joint Surg Br1999，6，： | 1 |
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