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| 1 | Computed tomography and patient risk:Facts,perceptions and uncertainties显示文摘Since its introduction in the 1970s, computed tomography(CT) has revolutionized diagnostic decision-making. One of the major concerns associated with the widespread use of CT is the associated increased radiation exposure incurred by patients. The link between ionizing radiation and the subsequent development of neoplasia has been largely based on extrapolating data from studies of survivors of the atomic bombs dropped in Japan in 1945 and on assessments of the increased relative risk of neoplasia in those occupationally exposed to radiation within the nuclear industry. However, the association between exposure to low-dose radiation from diagnostic imaging examinations and oncogenesis remains unclear. With improved technology, significant advances have already been achieved with regards to radiation dose reduction. There are several dose optimization strategies available that may be readily employed including omitting unnecessary images at the ends of acquired series, minimizing the number of phases acquired, and the use of automated exposure control as opposed to fixed tube current techniques. In addition, new image reconstruction techniques that reduce radiation dose have been developed in recent years with promising results. These techniques use iterative reconstruction algorithms to attain diagnostic quality images with reduced image noise at lower radiation doses. | Stephen P Power Fiachra Moloney Maria Twomey Karl James Owen J O'Connor Michael M Maher | 2016 | World Journal of Radiology2016，8，12： | 7 |
| 2 | Cost benefit analysis of the use of tranexamic acid in primary lower limb arthroplasty: A retrospective cohort study显示文摘AIM: To examine the cost benefit conferred by the perioperative administration of intravenous tranexamic acid(TXA) in lower limb arthroplasty.METHODS: This study evaluates the use of TXA in 200 consecutive lower limb arthroplasties performed in a single surgeon series. The initial 100 patients(control group) underwent surgery without perioperative administration of TXA while the subsequent 100 patients(TXA group) all received 1 g TXA at the time of induction of anaesthesia. Pre- and post-operative haemoglobin, platelet count, haematocrit, the use of blood product post-operatively, length of stay were examined. A financial analysis of both groups was then undertaken. RESULTS: The mean age of patients in both groups was 63 ± 13 years. There were no significant differences between groups in terms of gender(P = 0.47), proportion of total hip replacement to total knee replacement(P = 0.25) or pre-operative haemoglobin(P = 0.43). In the control group, the transfusion rate was 22%. In the TXA group, the transfusion rate dropped to 2%(P < 0.001). The mean post-operative haemoglobin was 10.82 ± 1.55g/dL in the control group vs 11.33 ± 1.27 g/dL in the TXA group(P = 0.01). The total cost of transfused blood products was €11055 and €603 respectively. The mean length of stay in the control group was 6.53 ± 5.93 d vs 5.47 ± 4.26 d in the TXA group(P = 0.15) leading to an estimated financial saving of €114586. There was one pulmonary embolus in the control group and one deep venous thrombosis in the TXA group.CONCLUSION: Intravenous TXA reduces blood loss in lower limb arthroplasty. This leads to lower transfusion rates, shorter length of stay in hospital and significant financial savings. | Niall P McGoldrick Eabhann M O'Connor Nikos Davarinos Rose Galvin John F Quinlan | 2015 | World Journal of Orthopedics2015，6，11： | 3 |
| 3 | C-reactive protein and radiographic findings of lower respiratory tract infection in infants显示文摘AIM To evaluate the association between C-reactive protein(CRP) and radiological evidence of lower respiratory tract infection(LRTI) in infants.METHODS All patients aged less than 4 years who presented with suspected lower respiratory tract infection,who received a peri-presentation chest radiograph and CRP blood measurement over an 18-mo period were included in the study.Age,gender,source of referral,CRP,white cell count,neutrophil count along with the patients' symptoms and radiologist's report were recorded.RESULTS Three hundred and eleven patients met the inclusioncriteria.Abnormal chest radiographs were more common in patients with elevated CRP levels(P < 0.01).Radiologic signs of LRTI were identified in 73.7% of chest radiographs when a patient had a CRP level between 50-99 mg/L.CRP levels were a better predictor of positive chest radiograph findings for those aged greater than I year compared to those 1 year or less.CONCLUSION CRP may be used in patients with suspected LRTI diagnosis to select those who are likely to have positive findings on chest radiograph,thus reducing unnecessary chest radiographs. | Maria Twomey Hannah Fleming Fiachra Moloney Kevin P Murphy Lee Crush Siobhan B O’Neill Oisin Flanagan Karl James Conor Bogue Owen J O’Connor Michael M Maher | 2017 | World Journal of Radiology2017，9，4： | 2 |
| 4 | Outcomes after arthroscopic repair of rotator cuff tears in the setting of mild to moderate glenohumeral osteoarthritis显示文摘BACKGROUND Rotator cuff pathology is a very common source of shoulder pain.Similarly,osteoarthritis of the glenohumeral joint can cause shoulder pain and produce similar symptoms.Surgical management can be indicated for both pathologies,however,outcomes data is limited when examining rotator cuff repair(RCR) in the setting of glenohumeral arthritis(GHOA).Thus,this study sought to determine outcomes for patients who undergo RCR in the setting of GHOA.AIM To evaluate if a relationship exists between outcomes of RCR in the setting of GHOA.METHODS This was a retrospective analysis of patients who underwent arthroscopic rotator cuff repair with concurrent glenohumeral osteoarthritis between 2010-2017.Patients were stratified based on rotator cuff tear size and glenohumeral osteoarthritis severity.Cohorts were paired 1:1 with patients without glenohumeral osteoarthritis.Patients included had a minimum two year follow-up.Rate of conversion to total shoulder arthroplasty,complication rates following initial surgery,and patient-reported outcome measures were collected.RESULTS A total of 142 patients were included.The number of patients that required total shoulder arthroplasty within two years after index surgery was low.2/71(2.8%) patients with GHOA,and 1/71(1.4%) without GHOA.Following rotator cuff repair,both groups showed favorable patientreported outcomes.CONCLUSION Patients with glenohumeral osteoarthritis who underwent arthroscopic rotator cuff repair showed comparable outcomes to patients without glenohumeral osteoarthritis. | Ian S Hong Allison J Rao Tyler L CarlLee Joshua D Meade Daniel J Hurwit Gregory Scarola David P Trofa Shadley C Schiffern Nady Hamid Patrick M Connor James E Fleischli Bryan Michael Saltzman | 2022 | World Journal of Orthopedics2022，13，7： | 2 |
| 5 | Neuronal death and survival in two models of hypoxic-ischemic brain damage 显示文摘 | Walton M Connor B Lawlor P | 1999 | Brain Res Rev1999，29，23： | 2 |
| 6 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus | 2010 | The Lancet2010，，9739： | 2 |
| 7 | Evaluation of performance characteristics of the medicinal leech(hirudo medicinalis) for the treatment of venous congestion显示文摘 | CONNOR N P HEISEY D M | 2002 | Plast Reconstr Surg2002，109，1： | 1 |
| 8 | The role of rituximab and chemotherapy in aggressive B-cell lymphoma:a preliminary report of dose-adjusted EPOCH-R显示文摘 | Wilson WH Gutierrez M O′Connor P | 2002 | Semin Oncol2002，29，12： | 1 |
| 9 | The role of rituximab and chemotherapy in aggressive B-cell lymphoma: a preliminary report of dose- adjusted EPOCH - R显示文摘 | Wilson W H Gutierrez M O'Connor P | 2002 | Semin Oncol2002，29，12： | 1 |
| 10 | Phosphorus sorption capacities of wetland soils and stream sediments impacted by dairy effluent显示文摘 | Reddy K R O'Connor G A Gale P M | 1998 | J Environ Qual1998，27，： | 1 |
| 11 | Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1 显示文摘 | Zingarelli B Hake P W O Connor M | 2004 | Am J Physiol Heart Circ Physiol2004，286，4： | 1 |
| 12 | Neuronal death and survival in two models of hypoxic-ischemic damage显示文摘 | Walton M Connor B Lawlor P | 1999 | Brain Res Brain Res Rev1999，29，23： | 1 |
| 13 | Adult exposure influences offspring response to ocean acidification in oysters显示文摘 | Parker L M Ross P M O'Connor W A | 2012 | Global Change Biology2012，18，1： | 1 |
| 14 | Neuronal death and survival in two models of hypoxic -ischemic damage显示文摘 | Walton M Connor B lawlor P | 1999 | Brain Res Brain Res Rev1999，29，： | 1 |
| 15 | Attitudes of children with dysphonia显示文摘 | Connor N P Cohen S B Theis S M | 2008 | JVoice2008，22，2： | 1 |
| 16 | Minimally invasive retroperitoneal pancreatic necrosectomy显示文摘 | Connor S Ghaneh P Raraty M | 2003 | Dig Surg2003，20，4： | 1 |
| 17 | Premenarcheal gymnasts possess higher bone mineral density than controls显示文摘 | Nickols-richardson S M Modlesky C M O'Connor P J | 2000 | Med Sci Sports Exerc2000，32，1： | 1 |
| 18 | Nasolacrimal intubation in adults显示文摘 | Fulcher T O'Connor M Moriarty P | 1998 | Br J Ophthalmol1998，82，9： | 1 |
| 19 | Synthesis, SAR, and atropisomerism of imidazolopy- rimidine DPP-4 inhibitors 显示文摘 | O'CONNOR S P WANG Y SIMPKINS L M | 2010 | Bioorg Med Chem Lett2010，20，21： | 1 |
| 20 | The effect of fat content on the microbiology and proteolysis in Cheddar cheese during ripening显示文摘 | Fenelon M O’Connor P Guinee T | 2000 | Journal of Dairy Science2000，83，10： | 1 |
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