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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | A study of 4-substituted 5,5-diaryl oxazolidin-2-ones as efficacious chiral auxiliaries显示文摘 | Gibson C L Gillon K Cook S | 1998 | Tetrahedron Lett1998，39，： | 1 |
| 3 | Analysis of compressive fracture in rock using statistical techniques : Part II : effect of mi- croscale heterogeneity on macroscopic deformation 显示文摘 | Blair S C Cook N G | 1998 | International Journal of Rock Mechanics and Mining Sciences 8< Geomechanics Abstracts1998，35，7： | 1 |
| 4 | Results of the pilot studyfor the Hypertension in the Very Elderly Trial显示文摘 | Bulpitt C J Beckett N S Cooke J | 2003 | J Hypertens2003，21，12： | 1 |
| 5 | Fractionation of polyethylene显示文摘 | FRSNCIS P S COOKE R C Jr ELLIOTT J H | 1958 | J Polym Sci1958，31，123： | 1 |
| 6 | Risk of deep vein thrombosis and pulmonary embolism after acute infection in a community setting 显示文摘 | Smeeth L Cook C Thomas S | 2006 | The Lancet2006，367，9516： | 1 |
| 7 | Atmospheric Corrosion of Different Steels in Marine, Rural and Industrial Environments 显示文摘 | Oh S J Cook D C Townsend H E | 1999 | Corrosion Science1999，41，3： | 1 |
| 8 | The deglacial history of surface and intermediate water of the Bering Sea显示文摘 | Cook M S Keigwin L D Sancetta C A | 2005 | Deep-Sea Research IT2005，52，： | 1 |
| 9 | Vegetative pro- duction of kenaf and canola under irrigation in central Califor- nia显示文摘 | BANUELOS G S BRYLA D R COOK C G | 2002 | Industrial Crops and Products2002，15，3： | 1 |
| 10 | Use of coded wire tags for marking fingerling fishes显示文摘 | COOK S B | 1988 | North American Journal of Fisheries Management1988，8，2： | 1 |
| 11 | Sequencing the genespaces of Medicago truncatula and Lotus japonicusl显示文摘 | Cannon S Sato S Kim D Cook D Town C Roe B Tabata S | 2005 | Plant Physiology2005，137，： | 1 |
| 12 | Risk of deep vein thrombosis and pulmonary embolism after acute infection in a community setting显示文摘 | Smeeth L Cook C Thomas S | 2006 | Lancet2006，367，9516： | 1 |
| 13 | Atmospheric Corrosion of Different Steels in Marine, Rural and Industrial Environments 显示文摘 | Oh S J Cook D C Townsend H E | 1999 | Corrosion Scienee1999，41，9： | 1 |
| 14 | Self-processing 2A polyproteins-a system for co-ordinate expression of multiple pro teins in transgenic plants显示文摘 | Halpin C Cooke S E Barakate A | 1999 | J The Plant Joural1999，17，4： | 1 |
| 15 | Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents显示文摘 | Ford ES Li C Cook S | 2007 | Circulation2007，115，19： | 1 |
| 16 | The mechanisms of the formation and growth of water bubbles and associated dislocation loops in synthetic quartz显示文摘 | McLaren A C Cook R F Hyde S T | 1983 | Phys Chem Mineral1983，9，： | 1 |
| 17 | Effects of the pesticides carbofuran,chlorprifos,dimethoate,lindane,triallate,trifluralin,2,4-D,and pentachlorophenol on the metabolic endocrine and reproductive endocrine system in ewes显示文摘 | RAWLINGS N C COOK S J WALDBILLIG D | 1998 | Journal Toxicol Environ health1998，54，1： | 1 |
| 18 | Testing computer-controlled infusion pumps by simulation显示文摘 | SHAFER S L SIEGEL L C COOKE J E | 1988 | Anesthesiology1988，68，26： | 1 |
| 19 | Serum transferrin receptor: a quantitative measure of tissue iron deficiency显示文摘 | Skikne B S Flowers C H Cook J D | 1990 | Blood1990，75，： | 1 |
| 20 | Removal of oil,grease,and suspended solids from produced water with ceramic crossflow microfiltration显示文摘 | Chen A S C Flynn J T Cook R G | 1991 | SPE Production Engineering1991，6，2： | 1 |
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