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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Diurnal variations in hydraulic conductivity and root pressure can be correlated with the expression of putative aquaporlns in the roots of Lotus japonicus显示文摘 | HENZLER T WATERHOUSE R N SMYTH A J CARVAJAL M COOKE D T SCHAFFNER A R STEUDLE E CLARKSOND T | 1999 | Planta1999，210，： | 1 |
| 3 | A methodology for the as- sessment of unconventional(continuous) resources with an ap- plication to the Greater Natural Buttes Gas Field, Utah显示文摘 | Olea R A Cook T A Coleman J L | 2010 | Natural Resources Research2010，19，4： | 1 |
| 4 | Ethanol causes accelerated GI arrest in differentiating HL260 cells显示文摘 | COOK R T KEINER J A YEN A | 1990 | Alc Clin Exp Res1990，14，： | 1 |
| 5 | Bonded stress model for design of adhesive anchors 显示文摘 | Cook R A Dpeer G T Klingner R E | 1993 | ACI Structural Journal1993，90，5： | 1 |
| 6 | A methodology for theassessment of unconventional(continuous) resources with anapplication to the greater natural Buttes gas field, Utah显示文摘 | Olea R A Cook T A Coleman J L | 2010 | NaturalResources Research2010，19，4： | 1 |
| 7 | The mechanisms of the formation and growth of water bubbles and associated dislocation loops in synthetic quartz显示文摘 | McLaren A C Cook R F Hyde S T | 1983 | Phys Chem Mineral1983，9，： | 1 |
| 8 | Mimosine arrests the cell cycle after cells enter S-phase显示文摘 | Hughes T A Cook P R | 1996 | Exp Cell Res1996，222，2： | 1 |
| 9 | Removal of oil,grease,and suspended solids from produced water with ceramic crossflow microfiltration显示文摘 | Chen A S C Flynn J T Cook R G | 1991 | SPE Production Engineering1991，6，2： | 1 |
| 10 | Rates of stone loss at St Paul' s Cathedral, London 显示文摘 | Trudgill S T Viles H A Cooke R U | 1990 | Atmospheric Enviroltment ( Part B)1990，24，2： | 1 |
| 11 | Bond stress model for design of adhesive anchors显示文摘 | Cook R A Doerr G T Klingner R E | 1993 | ACI Structural Journal1993，90，5： | 1 |
| 12 | Methods for assessing responsiveness:a critical review and recommendations显示文摘 | Husted J A Cook R J Farewell V T | 2000 | J Clin Epidemiol2000，53，5： | 1 |
| 13 | Trendsin stone weathering and atmospheric-pollution at St-Pauls-Cathedral, Lon- don, 1980-1990 显示文摘 | Trudgill S T Viles H A Cooke R U | 1991 | Atmospheric Environment ( Part A )1991，25，： | 1 |
| 14 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 15 | Methods for assessing responsiveness: a critical review and rec- ommendations 显示文摘 | HUSTED J A COOK R J FAREWELL V T | 2000 | J Clin Epitlemidl2000，53，5： | 1 |
| 16 | Forest decline: Modeling the effect of climate in tree ring 显示文摘 | COOK E R JOHNSON A H BLASING T J | 1987 | Tree Physiology1987，3，1： | 1 |
| 17 | Weathering of the balustrade on St Paul's Cathedral, London显示文摘 | SHARP A D TRUDGILL S T COOKE R U | 1982 | Earth Surface Processes and Landforms1982，7，4： | 1 |
| 18 | Effect of feeding isoacids with urea on growth and nutrient utilizition by lactating cows显示文摘 | Felix A Cook R M Huber J T | 1980 | J Dairy Sci1980，63，11： | 1 |
| 19 | CH4 oxidation in soils fertilized with organic and inorganic N; differential effects显示文摘 | COOK R MULLER A | 1996 | Soil Biol Biochem1996，28，： | 1 |
| 20 | Evaluating the administrative efficiency of courts显示文摘 | Lewin A Y Morey R C Cook T J | 1982 | OMEGA Internation Journal of Management Science1982，10，4： | 1 |
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