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| 1 | Histone deacetylase inhibitors for treatment of hepatocellular carcinoma显示文摘肝细胞癌(HCC ) 是在世界上的最普通的癌症之一。外科的切除术被认为最佳的治疗途径,但是仅仅病人的一个小比例是外科的合适的候选人,并且恶化率高。来临阻止复发,包括 chemoembolization 在前和在外科以后的辅助治疗,证明了有一个有限好处;肝移植在因为仅仅少数病人为移植取得资格,对待有限阶段的 HCC 是成功的。因此,新治疗学的策略着急地被需要。因为除了删除或使失去活性的点变化的古典基因机制,渐成说改变,例如 hyperacetylation 联系染色质嘘(为基因 silencing 负责),被相信涉及 HCC 的发展和前进,赋予以的新奇混合物一hist 一 deacetylase ( HDAC )禁止的活动是一条吸引人的治疗学的途径。特别地,现出症状之前的潜的结果获得了使用哈 -- ,但是,酪酸残余是到一根透明质酸脊梁的 esterified 并且为膜受体 CD44 由一种高亲密关系描绘的一个 HDAC 在禁止者,显示混合物的这个班可以为肝细胞癌治疗代表一条有希望的途径。 | Danila CORADINI Annalisa SPERANZA | 2005 | Acta Pharmacologica Sinica2005，26，9： | 5 |
| 2 | Differential expression of genes involved in the epigenetic regulation of cell identity in normal human mammary cell commitment and differentiation显示文摘The establishment and maintenance of mammary epithelial cell identity depends on the activity of a group of proteins, collectively called maintenance proteins, that act as epigenetic regulators of gene transcription through DNA methylation, histone modification, and chromatin remodeling. Increasing evidence indicates that dysregulation of these crucial proteins may disrupt epithelial cell integrity and trigger breast tumor initiation. Therefore, we explored in silico the expression pattern of a panel of 369 genes known to be involved in the establishment and maintenance of epithelial cell identity and mammary gland remodeling in cell subpopulations isolated from normal human mammary tissue and selectively enriched in their content of bipotent progenitors, committed luminal progenitors, and differentiated myoepithelial or differentiated luminal cells. The results indicated that, compared to bipotent cells, differentiated myoepithelial and luminal subpopulations were both characterized by the differential expression of 4 genes involved in cell identity maintenance: CBX6 and PCGF2, encoding proteins belonging to the Polycomb group, and SMARCD3 and SMARCE1, encoding proteins belonging to the Trithorax group. In addition to these common genes, the myoepithelial phenotype was associated with the differential expression of HDAC1, which encodes histone deacetylase 1, whereas the luminal phenotype was associated with the differential expression of SMARCA4 and HAT1, which encode a Trithorax protein and histone acetylase 1, respectively. The luminal compartment was further characterized by the overexpression of ALDH1A3 and GATA3, and the down-regulation of NOTCH4 and CCNB1, with the latter suggesting a block in cell cycle progression at the G2 phase. In contrast, myoepithelial differentiation was associated with the overexpression of MYC and the down-regulation of CCNE1, with the latter suggesting a block in cell cycle progression at the G1 phase. | Danila Coradini Patrizia Boracchi Saro Oriana Elia Biganzoli Federico Ambrogi | 2014 | Chinese Journal of Cancer2014，33，10： | 2 |
| 3 | Epithelial cell polarity and tumorigenesis: new perspectives for cancer detection and treatment显示文摘房间房间粘附和房间极性的损失通常与他们的侵略在上皮的起源和相互关联的肿瘤被观察进转移的邻近的纸巾和形成。成长证据显示房间极性和房间房间粘附的损失可能也在癌症的早舞台是重要的。在这评论的第一部分,我们描出建立并且维持并且在肿瘤讨论房间极性和顶端的 junctional 建筑群部件的参与上皮的纸巾的极性的机制的当前的理解致病。在第二部分,我们在癌症诊断和预后探讨房间极性和 junctional 建筑群部件的临床的意义。最后,我们在癌症的治疗作为治疗学的目标探索他们的潜在的使用。 | Danila CORADINI Claudia CASARSA Saro ORIANA | 2011 | Acta Pharmacologica Sinica2011，32，5： | 2 |
| 4 | Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties显示文摘 | Ponti D Costa A Zaffaroni N Pratesi G Petrangolini G Coradini D | 2005 | Cancer Res2005，65，： | 1 |
| 5 | Inhibition of hepatoeellular carcinomas in vitro and hepatic metastases in vivo in mice by the histone deacetylase inhibitor HA - But 显示文摘 | Coradini D Zorzet S Rossin R | 2004 | Clin Cancer Res2004，10，： | 1 |
| 6 | Hyaluronic acid as drug delivery for sodium butyrate: improvement of the anti-proliferative activity on a breast-cancer cell line显示文摘 | Coradini D Pellizzaro C Miglierini G | 1999 | Int J Cancer1999，81，3： | 1 |
| 7 | Hyaluronic-acid butyric esters as promising antineoplastic agents in human lung carcinoma: A preclinical study显示文摘 | Coradini D Pellizzaro C Abolafio G | 1998 | J Controlled Release1998，50，13： | 1 |
| 8 | Re:Levels of hypoxia-inducible factor-1alpha during breast carcinogenesis显示文摘 | Costa A Coradini D Carrassi A | 2001 | J Natl Cancer Inst2001，93，15： | 1 |
| 9 | p53 status identifies two subgroups of triple-negative breast cancers with distinct biological features 显示文摘 | Biganzoli E Coradini D Ambrogi F | 2011 | Jpn J Clin Oncol2011，41，2： | 1 |
| 10 | Modulation of angiogenesis-related proteins synthesis by sodium butyrate in colon cancer cell line HT29显示文摘 | Pellizzaro C Coradini D Daidone MG | 2002 | Carcinogenesis2002，23，5： | 1 |
| 11 | Antiproliferative Effect of Fermented Milk on the Growth of A Human Breast Cancer Cell Line显示文摘 | BIFFI A CORADINI D LARSEN R | 1997 | Nutrition and Cancer1997，28，： | 1 |
| 12 | Sodium butyrate modulates cell cycle-related proteins in HT29 human colonic adenocarcinoma cells显示文摘 | Coradini D Pellizzaro C Marimpietri D | 2000 | Cell Prolif2000，33，3： | 1 |
| 13 | Antiproliferative effect of fermented milk on the growth of a human breast cancer cell line显示文摘 | BIFFI A CORADINI D | 1997 | Nutr Cancer1997，28，1： | 1 |
| 14 | Free and nanoencapsu- lated curcumin suppress β - amyloid - induced cognitive impair- ments in rats: involvement of BDNF and Akt/GSK -3β signaling pathway显示文摘 | Hoppe JB Coradini K Frozza RL | 2013 | Neurebiol Learn Mem2013，106，： | 1 |
| 15 | Antiproliferative effect of fermented milk on the growth of a human breast cancer cell line显示文摘 | BIFFI A CORADINI D LAR SEN R | 1997 | Nutrition and Cancer1997，28，： | 1 |
| 16 | TP53 mutation, epitheli- al--mesenchymal transition, and stemlike features in breast cancer subtypes显示文摘 | Coradini D Fomili M Ambrogi F | 2012 | J Biomed Biotectmol2012，2012，25： | 1 |
| 17 | P53 status identifies two subgroups of triple-negative breast cancers with distinct biological features显示文摘 | Biganzoli E Coradini D Ambrogi F | 2011 | Jpn J Clin Oncol2011，41，2： | 1 |
| 18 | TP53 mu- tation, epithelial-mesenchymal transition, and stemlike features in breast cancer subtypes 显示文摘 | CORADINI D FORNILI M AMBROGI F | 2012 | J Biomed Biotechn- ol2012，2012，25： | 1 |
| 19 | TP3 mutation, epithelial-mesenchymal transition, and stemlike features in breast cancer subtypes 显示文摘 | DANILA CORADINI MARCO FORNILI FEDERICO AMBRO- GI | 2012 | J Biomed Biotechnol2012，10，： | 1 |
| 20 | Co- encapsulation of resveratrol and curcumin in lipid-core nanocapsules improves their in vitro antioxidant effects 显示文摘 | CORADINI K LIMA F O OLIVEIRA C M | 2014 | Eur J Pharm Biopharm2014，88，： | 1 |
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