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| 1 | T_3-induced liver AMP-activated protein kinase signaling:Redox dependency and upregulation of downstream targets显示文摘AIM:To investigate the redox dependency and promotion of downstream targets in thyroid hormone(T3)-induced AMP-activated protein kinase(AMPK)signaling as cellular energy sensor to limit metabolic stresses in the liver.METHODS:Fed male Sprague-Dawley rats were given a single ip dose of 0.1 mg T3/kg or T3 vehicle(Na OH0.1 N;controls)and studied at 8 or 24 h after treatment.Separate groups of animals received 500 mg N-acetylcysteine(NAC)/kg or saline ip 30 min prior T3.Measurements included plasma and liver 8-isoprostane and serumβ-hydroxybutyrate levels(ELISA),hepaticlevels of m RNAs(q PCR),proteins(Western blot),and phosphorylated AMPK(ELISA).RESULTS:T3 upregulates AMPK signaling,including the upstream kinases Ca2+-calmodulin-dependent protein kinase kinase-βand transforming growth factor-β-activated kinase-1,with T3-induced reactive oxygen species having a causal role due to its suppression by pretreatment with the antioxidant NAC.Accordingly,AMPK targets acetyl-Co A carboxylase and cyclic AMP response element binding protein are phosphorylated,with the concomitant carnitine palmitoyltransferase-1α(CPT-1α)activation and higher expression of peroxisome proliferator-activated receptor-γco-activator-1αand that of the fatty acid oxidation(FAO)-related enzymes CPT-1α,acyl-Co A oxidase 1,and acylCo A thioesterase 2.Under these conditions,T3 induced a significant increase in the serum levels ofβ-hydroxybutyrate,a surrogate marker for hepatic FAO.CONCLUSION:T3 administration activates liver AMPK signaling in a redox-dependent manner,leading to FAO enhancement as evidenced by the consequent ketogenic response,which may constitute a key molecular mechanism regulating energy dynamics to support T3preconditioning against ischemia-reperfusion injury. | Luis A Videla Virginia Fernández Pamela Cornejo Romina Vargas Paula Morales Juan Ceballo Alvaro Fischer Nicolás Escudero Oscar Escobar | 2014 | World Journal of Gastroenterology2014，20，46： | 3 |
| 2 | Reactions of genistein with alkylperoxyl radicals显示文摘 | Arora A Valcic S Cornejo S | 2000 | Chem Res Toxicol2000，13，7： | 1 |
| 3 | Studies on the decontamination of air by Chilean plants显示文摘 | Cornejo J J Munoz F G Ma C Y Stewart A J | 1999 | Ecotoxicology1999，8，： | 1 |
| 4 | Studies on the origin of microorganisms multiplying during manufacture of dry cured raw ham显示文摘 | CORNEJO I CARRASCOSA A V MARIN M E | 1992 | Fleischwirtschaft1992，72，10： | 1 |
| 5 | The first immobilization of pyridine-bis(oxazoline) chiral ligands显示文摘 | CORNEJO A FRAILE J M GARCIA J I | | 0，，22： | 1 |
| 6 | Occurrence and distribution of microorganisms on the surface of dry cured Spanish ham 显示文摘 | CARRASCOSA A V CORNEJO I MARIN M E | 1992 | Fleischwirtschaft1992，72，7： | 1 |
| 7 | Characterization of micrococcaceae strains selected as potential starter cultures to Spanish dry-cured ham processes显示文摘 | CARRASCOSA A V CORNEJO I | 1991 | Fleischwirtschaft1991，71，10： | 1 |
| 8 | Hydrotalcite as sorbent for trinitrophenol sorption capacity and mechanism显示文摘 | Hermosín M C Pavlovic I Ulibarri M A Cornejo J | 1996 | Water research1996，30，1： | 1 |
| 9 | Cellular automaton model for evacuation process with obstacles 显示文摘 | VARAS A CORNEJO M D MAINEMER M | 2007 | Physica A2007，382，2： | 1 |
| 10 | Occurrence and distribution of microorganisms on the surface of dry cured Spanish ham 显示文摘 | CARRASCOSA A V CORNEJO I MARIN M E | 1992 | Fleischwirts Chart1992，72，7： | 1 |
| 11 | Cellular automaton model for evacuation process with obstacles显示文摘 | Varas A Cornejo M D Mainemer D | 2007 | Physica A: Statistical Mechanics and its Applications2007，382，2： | 1 |
| 12 | Cellular automaton model for evacuation process with obstacles显示文摘 | Varas A Cornejo M D Mainemer D | 2007 | Physica A2007，382，： | 1 |
| 13 | Comparison of 18-carboxypropylbetaine and glass bead DNA extraction methods for detection of Mycobacterium bovis in bovine milk samples and analysis of samples by PCR显示文摘 | Cornejo B J Sahagun-Ruiz A Suarez-Guemes F | 1998 | Appl Environ Microbiol1998，64，： | 1 |
| 14 | Osteochondroma ofthe coronoid process显示文摘 | Villanueva J Gonzalez A Cornejo M | 2006 | Med Oral Patol Oral Cir Bucal2006，11，3： | 1 |
| 15 | Renal function at hospital admission as a prognostic factor in adult hemolytic uremic syndrome: The Italian Registry of Haemolytic Uremic Syndrome 显示文摘 | Schieppati A Ruggenenti P Cornejo R P | 1992 | J Am Soc Nephrol1992，2，： | 1 |
| 16 | Nuclear bioavailability of the glucocorticoid receptor in a pediatric asthma cohort with variable corticosteroid responsiveness显示文摘 | CORNEJO S TANTISIRA K RABY B A | 2015 | Pediatr Res2015，78，5： | 1 |
| 17 | Cryopreserved callus:A source of protoplasts for rice transformation显示文摘 | Cornejo M J Wong V I Blechl A E | 1995 | Plant Cell Reports1995，14，2： | 1 |
| 18 | Cellular automaton model for evacuation process with obstacles 显示文摘 | Varas A Cornejo M D Mainemer D | 2007 | Physica A2007，382，2： | 1 |
| 19 | A novel protein phosphatase 2A (PP2A) is involved in the transformation of human protozoan parasite Trypanosoma cruzi显示文摘 | GONZALEZ J CORNEJO A SANTOS MR | 2003 | Biochem J2003，374，3： | 1 |
| 20 | Cellular automaton model for evacuation process with obstacles 显示文摘 | VARAS A CORNEJO M D MAINEMER D | 2007 | Physica A2007，382，2： | 1 |
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