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| 1 | Adsorptive hemofiltration for sepsis management: expert recommendations based on the Asia Pacific experience显示文摘To the Editor:In sepsis,bacterial endotoxins play a central role by inducing a dysregulated and exaggerated release of inflammatory mediators and cytokines,often described as the“cytokine storm”or“cytokinemia.”[1]Both endotoxins and cytokines have been implicated in the development of organ dysfunction,including acute kidney injury(AKI).[2]Removing circulating endotoxins and excess cytokines from the circulation restores chemotactic gradients,localizing the immune response to the principal site of infection and re-establishing a regulated immune response.[1,3]Therefore,using hemofilters with enhanced endotoxin and cytokine adsorptive properties may bring about additional therapeutic benefits compared with conventional continuous renal replacement therapy(CRRT)filters. | Ling Zhang Matthew Cove Binh G.Nguyen Nuttha Lumlertgul Kartik Ganesh Alfred Chan Giang T.H.Bui Chunwen Guo Junhua Li Songqiao Liu Mian Peng Kit W.Foong Jian Zhang Minmin Wang Jacques Goldstein Kai Harenski | 2021 | Chinese Medical Journal2021，，18： | 6 |
| 2 | Involvement of substance P and the NK-1 receptor in pancreatic cancer显示文摘Pancreatic cancer is the fourth leading cause of cancer related-death for both men and women and the 1-and5-year relative survival rates are 25%and 6%,respectively.Thus,it is urgent to investigate new antitumor drugs to improve the survival of pancreatic cancer patients.The peptide substance P(SP)has a widespread distribution throughout the body.After binding to the neurokinin-1(NK-1)receptor,SP regulates biological functions related to cancer,such as tumor cell proliferation,neoangiogenesis,the migration of tumor cells for invasion,infiltration and metastasis,and it exerts an antiapoptotic effects on tumor cells.It is known that the SP/NK-1 receptor system is involved in pancreatic cancer progression:(1)pancreatic cancer cells and samples express NK-1 receptors;(2)the NK-1 receptor is overexpressed in pancreatic cancer cells in comparison with non-tumor cells;(3)nanomolar concentrations of SP induce pancreatic cancer cell proliferation;(4)NK-1 receptor antagonists inhibit pancreatic cell proliferation in a concentration-dependent manner,at a certain concentration,these antagonists inhibit100%of tumor cells;(5)this antitumor action is medi-ated through the NK-1 receptor,and tumor cells die by apoptosis;and(6)NK-1 receptor antagonists inhibit angiogenesis in pancreatic cancer xenografts.All these data suggest that the SP/NK-1 receptor system could play an important role in the development of pancreatic cancer;that the NK-1 receptor could be a new promising therapeutic target in pancreatic cancer,and that NK-1 receptor antagonists could improve the treatment of pancreatic cancer. | Miguel Muoz Rafael Coveas | 2014 | World Journal of Gastroenterology2014，20，9： | 4 |
| 3 | Chlorate toxicity in Aspergillus nidulans : Studies of mutants altered in nitrate assimilation 显示文摘 | Cove D J | 1976 | Molecular Genetic Genet1976，146，： | 1 |
| 4 | Almost total replacement of fish meal by plant protein sources in the diet of a marine teleost, the European seabass, Dicentearehus labrax 显示文摘 | Kaudshik S J Coves D Dutto G | 2004 | Aquaculture2004，230，14： | 1 |
| 5 | Heparin stimulates the proliferation of intestinal epithelial cells in primary culture显示文摘 | FLINT N COVE F L EVANS G S | 1994 | J Cell Sci1994，107，2： | 1 |
| 6 | Cytolysin gene expression in Enterococcus faecalis is regulated in response to aerobiosis conditions 显示文摘 | Day AM Cove JH Phillips-Jones MK | 2003 | Mol Genet Genomics2003，269，1： | 1 |
| 7 | Strategic management of small firms in hostile and benign environments 显示文摘 | COVING I SLEVIN D P | 1989 | Strategic Management Journal1989，，10： | 1 |
| 8 | Sequence analysis of expressed sequence tags from an ABA-treated cDNA library identifies stress response genes in the moss Physcomitrella patterns显示文摘 | Machuka J Bashiardes S Ruben E Spooner K Cuming A Knight C Cove D | 1999 | Plant Cell Physiol1999，40，4： | 1 |
| 9 | Contacts among non - sister dendritic branches at bifurcations shape neighboring dendrites and pattern their synaptic inputs显示文摘 | COVE J BLINDER P BARANES D | 2009 | Brain Res2009，1251，： | 1 |
| 10 | Regulation of feed intake, growth, nutrient and energy utilisation in European seabass( Dicentrarchus labrax) fed high fat diets 显示文摘 | Boujard T Gelineau A Coves D | 2004 | Aquaculture2004，231，14： | 1 |
| 11 | Conversion of mouse fi- broblasts into cardiomyocytes using a direct reprogramming strategy 显示文摘 | Ere J A Hi]cove S Kim J etal | 2011 | Nature Cell Biology2011，13，3： | 1 |
| 12 | Superior antibacterial action and reduced incidence of bacterial resistance in minocycline compared to tetracycline-treated acne patients显示文摘 | Eady EA Cove JH Holland KT | 1990 | Br J Dermatol1990，122，2： | 1 |
| 13 | Posterior sternoclavicular dislocations : a review of management and complications 显示文摘 | Cove N Ebraheim NA Glass E | 2006 | Am J Orthop2006，3，： | 1 |
| 14 | Almost total replacement of fish meal by phnt protein sources in the diet of a marine teleost,the European seabass,Dicentrarchus labrax显示文摘 | Kaushik S J Cove's D Dutto G | 2004 | Aquaculture2004，230，： | 1 |
| 15 | Effect of chronic ammonia exposure on growth of European sea bass (Dicentrarchus labrax) juveniles显示文摘 | LEMARIE G DOSDAT A COVE S D | | 0，，： | 1 |
| 16 | The generation and modification of cell polarity显示文摘 | Cove D J | 2000 | Journal of Experimental Botany2000，51，346： | 1 |
| 17 | Superior antibacterial action and reduced incidence of bacterial resistance in minocycline compared to tetracycline- treated ache patients 显示文摘 | Eady EA Cove JH Holland KT | 1990 | Br J Dermatol1990，122，2： | 1 |
| 18 | Almost total replacement of fish meal by plant protein sources in the diet of a marine teleost, the European seabass, Dicentearchus L abrax 显示文摘 | Ksudhik S J Coves D Dutto G | 2004 | Aquaculture2004，230，： | 1 |
| 19 | Superior antibacterial action and reduced incidence of bacterial resistance in minocy- eline compared to tetracycline-treated ache patients 显示文摘 | Eady EA Cove JH Holland KT | 1990 | Br J Dermatol1990，122，： | 1 |
| 20 | Effect of chronic ammo- nia exposure on growth of European seabass (Dicentrarchus labrax) juveniles显示文摘 | Lemarie'G Dosdat A Cove's D | 2004 | Aquaculture2004，229，： | 1 |
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