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| 1 | Hepatic abscess induced by foreign body:Case report and literature review显示文摘Hepatic abscess due to perforation of the gastrointestinal tract caused by ingested foreign bodies is uncommon. Pre-operative diagnosis is difficult as patients are often unaware of the foreign body ingestion and symptoms and imagiology are usually non-specific. The authors report a case of 62-year-old woman who was admitted with fever and abdominal pain. Further investigation revealed hepatic abscess, without resolution despite antibiotic therapy. A liver abscess resulting from perforation and intra-hepatic migration of a bone coming from the pilorum was diagnosed by surgery. The literature concerning foreign body-induced perforation of the gastrointestinal tract complicated by liver abscess is reviewed. | Sofia A Santos Sara CF Alberto Elsa Cruz Eduardo Pires Tomás Figueira lia Coimbra José Estevez Mário Oliveira Luís Novais Joo R Deus | 2007 | World Journal of Gastroenterology2007，13，9： | 10 |
| 2 | Hypothalamic-pituitary-adrenal axis function during perinatal depression显示文摘Abnormal function of the hypothalamic–pituitary–adrenal(HPA) axis is an important pathological finding in pregnant women exhibiting major depressive disorder. They show high levels of cortisol proinflammatory cytokines, hypothalamic-pituitary peptide hormones and catecholamines, along with low dehydroepiandrosterone levels in plasma. During pregnancy, the TH2 balance together with the immune system and placental factors play crucial roles in the development of the fetal allograft to full term. These factors, when altered, may generate a persistent dysfunction of the HPA axis that may lead to an overt transfer of cortisol and toxicity to the fetus at the expense of reduced activity of placental 11β-hydroxysteroid dehydrogenase type 2. Epigenetic modifications also may contribute to the dysregulation of the HPA axis. Affective disorders in pregnant women should be taken seriously, and therapies focused on preventing the deleterious effects of stressors should be implemented to promote the welfare of both mother and baby. | Phillipe Leff Gelman Mónica Flores-Ramos Margarita López-Martínez Carlos Cruz Fuentes Juan Pablo Reyes Grajeda | 2015 | Neuroscience Bulletin2015，31，3： | 6 |
| 3 | 膳食硝酸盐通过减少交感神经过度激活的机制降低血管紧张素Ⅱ诱导的高血压大鼠的血压显示文摘几项实验和临床研究表明,膳食中添加硝酸盐可提高一氧化氮的生物利用度。在口腔中,共生细菌将硝酸盐还原成亚硝酸盐,其随后被吸收到循环中,通过酶系统还原为一氧化氮。已知增加硝酸盐-亚硝酸盐-一氧化氮途径可以改善心血管、肾脏和代谢功能,并且交感神经兴奋有助于疾病的进展,但是膳食硝酸盐对交感神经活动的潜在影响仍有待阐明。 | 刘莉 叶鹏 ■ DD Cruz JC ■ A Zhuge Z Marques SM Naves LM Persson AEG Weitzberg E Lundberg JO Balarini CM Pedrino GR Braga VA ■ M | 2019 | 中华高血压杂志2019，0，3： | 2 |
| 4 | The sensitizer 2,4-Dinitrofluorobenzene activates caspase-3 and induces cell death in a skin dendritic cell line显示文摘 | Cruz MT Duarte CB Goncalo M | 2003 | Int J Toxicol2003，22，1： | 2 |
| 5 | A parallel monte-carlo finite-element procedure for the analysis of multicomponent random media显示文摘 | Cruz M E Petera A | 1995 | International Journal for Numerical Methods in Engineering1995，38，： | 2 |
| 6 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 7 | 新型雄激素受体种系错义突变与非裔男性家族性前列腺癌显示文摘种族、家族史和年龄是众所周知的前列腺癌危险因素。雄激素受体依赖性信号传送是前列腺癌变和肿瘤转移的重要基础。非裔男性的前列腺癌发病率、死亡率高于白人,且临床恶性程度高。本实验探究了非裔男性家族性前列腺癌与雄激素受体(AR)基因突变之间的关系。实验中我们对参与路易斯安那州立大学健康科学中心前列腺癌遗传连锁研究的30个高危黑人和白人家庭的60名前列腺癌患者的基因组HDNA序列进行了检测。应用外显子特异性聚合酶链反应,双向自动测序和限制性内切酶基因分型分析AR基因编码区突变,结果在一个有早发前列腺癌家族史黑人家庭的3名成员中发现了种系AR-A1675T(T559S)替换突变,突变位于DNA结合区。本研究首次在患家族性前列腺癌的黑人男性中发现了种系雄激素受体突变,该突变可能会改变受体与DNA结合亲和力和/或对雄激素、非雄性类固醇或雄激素拈抗剂的反应。今后的研究应当探索AR(A1675T)序列对黑人早发和/或家族性前列腺癌的影响和影响频率。 | Si-Yi Hu Tao Liu Zhen-Zhen Liu Elisa Ledet Cruz Velasco-Gonzalez Diptasri M Mandal Shahriar Koochekpour | 2010 | Asian Journal of Andrology2010，12，3： | 2 |
| 8 | Performance and yield stability of maize hybrids in stress-prone environments in eastern Africa显示文摘Identification and deployment of high-yielding and stress-tolerant maize hybrids adapted to stress-prone agro-ecologies is important for improving the food security and livelihoods of smallholder farmers in eastern Africa.The objectives of this study were to(i)assess the performance of maize hybrids under well-watered and drought stress conditions;(ii)evaluate grain yield stability of 65 intermediate-maturing and 55 early-maturing hybrids in 24 well-watered locations and seven drought stress locations;and(iii)identify representative and/or discriminative testing locations for increasing genetic gains for the target traits.There were significant differences for grain yield among early-and intermediatematuring hybrids tested under well-watered and drought stress environments.Among the early-maturing hybrids,the top 10 hybrids produced 46.8%–73.9%and 31.2%–42.1%higher mean grain yields than the best commercial check under drought and well-watered conditions,respectively.Among the intermediate-maturing hybrids,the top 10 hybrids produced 25.2%–47.7%and 8.5%–13.5%higher grain yield than commercial checks under drought stress and well-watered conditions,respectively,suggesting improvement in the levels of drought tolerance in both early-and intermediate-maturing hybrids.GGE biplot analysis and a bi-segmented regression linear method identified specific early-maturing and intermediate-maturing hybrids that performed well under both well-watered and drought stress conditions.These hybrids could be recommended for commercial production in eastern Africa.Kakamega in Kenya was found to be the most representative and highly discriminating site among well-watered testing locations,while Kabuku in Tanzania was the least representative of test locations.For testing under drought stress conditions,Kiboko in Kenya was identified as the most representative location.This information could be useful for allocating resources and streamlining CIMMYT maize hybrid testing in eastern Africa. | Wender Santos Rezende Yoseph Beyene Stephen Mugo Eric Ndou Manje Gowda Julius Pyton Sserumaga Godfrey Asea Ismail Ngolinda McDonald Jumbo Sylvester O.Oikeh Michael Olsen Aluízio Borém Cosme Damião Cruz Boddupalli M.Prasanna | 2020 | The Crop Journal2020，8，1： | 2 |
| 9 | Chitosan microparticles as injectable scaffolds for tissue engineering 显示文摘 | CRUZ D M IVIRICO J L GOMES M M | 2008 | J Tissue Eng Regen Med2008，2，6： | 1 |
| 10 | The role of major histocompatibility complex alleles in the susceptibility of Brazi-lian patients to develop the myogenic type of Graves' orbitopathy显示文摘 | Akaishi P M Cruz A A Silva F L | 2008 | Thyroid2008，18，4： | 1 |
| 11 | Larval growth and survival of two catarina scallop ( Argopecten circularis , Sowerby, 1835 )populations and their reciprocal crosses 显示文摘 | Cruz P Ibarra A M | 1997 | Journal of Experimental Marine Biology and Ecology1997，212，： | 1 |
| 12 | Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans显示文摘 | Fox D S Cruz M C Sia R A L | 2001 | Molecular Microbiology2001，39，： | 1 |
| 13 | Purification of metallurgical grade silicon by acid leaching显示文摘 | SANTOS I C GONCALVES A P SANTOS C S ALMEIDA M AFONSO M H CRUZ M J | 1990 | Hydrometallurgy1990，23，： | 1 |
| 14 | Clay mineral assemblages in flysch from the Campo de Gibraltar area( Spain ) 显示文摘 | Cruz M D R | 1999 | Clay Mineralogy1999，34，2： | 1 |
| 15 | Study of the migration of benzophenone from printed paperboard packages to cakes through different plastic films 显示文摘 | Pastorelli S Sanches-Silva A Cruz J M | 2008 | Eur Food Res Technol2008，227，： | 1 |
| 16 | Larval growth and survival of two catarina scallop(Argopecten cirularis,Sowerby,1835)population and their reciprocal crosses显示文摘 | Pedro Cruz Ana M Ibarra | 1997 | Journal of Experimental Marine Biology and Ecology1997，212，： | 1 |
| 17 | Amphotericin B therapy: past, present, and future 显示文摘 | Peacock J E Herrington D A Cruz J M | 1993 | Infect Dis Clin Pract1993，2，： | 1 |
| 18 | Effect of different brood stock densities on the reproductive performance of Nile tilapia(Oreochrornis niloticus) in recycling system显示文摘 | RIDHA M T CRUZ E M | 1999 | Aquaculture Re search1999，30，： | 1 |
| 19 | Xylitol Production from Wood Hydrolyzaties by Entrapped Debammyas Hansenii and Candida Guilliermondi Cells显示文摘 | Dominguez J M Cruz J M Roca E | | 0，，： | 1 |
| 20 | Efficiency of chain codes to represent binary objects 显示文摘 | Sdnchez Cruz H Bribiesea E Rodriguez Diaz M A | 2007 | Pattern Recogni- tion2007，40，6： | 1 |
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