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	题名	作者	年代	出处	被引量
1	Relation of atrophic gastritis with Helicobacter pylori-CagA^+ and interleukin-1 gene polymorphisms显示文摘AIM: To determine the association of Helicobacter pylori (H pylori) CagA+ infection and pro-inflammatory poly-morphisms of the genes interleukin (IL)-1RN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of gastric cancer. METHODS: Seven biopsy specimens, a fasting blood sample and a questionnaire concerning nutritional and sociodemographic factors were obtained from 501 con-secutive patients who had undergone endoscopy for dyspeptic symptoms. A histopathological diagnosis was made. Pepsinogen concentrations were analyzed by enzyme linked immunosorbent assay (ELISA). Infection with H pylori CagA+ was determined by serology and polymerase chain reaction (PCR). IL-1B and IL-1RN polymorphisms genotyping was performed by PCR-restriction fragment length polymorphism (PCR-RFLP)and PCR respectively. RESULTS: In this dyspeptic population, 86% were H pylori positive and of these, 67.8% were positive for CagA. Atrophic antral gastritis (AAG) was associated with CagA+ status [odd ratio (OR) = 4.1; P < 0.000] and fruit consumption (OR = 0.3; P < 0.00). Atrophic body gastritis (ABG) was associated with pepsinogen PGI/PGII < 3.4 (OR = 4.9; P < 0.04) and alcohol consumption (OR = 7.3; P < 0.02). Duodenal ulcer was associated with CagA+ (OR = 2.9; P < 0.04) and smoking (OR = 2.4; P < 0.04). PGI < 60 μg/L as well as PGI/PGII < 3.4 were associated with CagA+. CONCLUSION: In a dyspeptic population in Costa Rica, H pylori CagA+ is not associated with ABG, but it is a risk factor for AAG. The pro-inflammatory cytokine poly-morphisms IL-1B + 3945 and IL-1RN are not associated with the atrophic lesions of this dyspeptic population.	Rafaela Sierra Clas Une Vanessa Ramírez Warner Alpízar-Alpízar María I González José A Ramírez Antoine de Mascarel Patricia Cuenca Guillermo Pérez-Pérez Francis Mégraud	2008	World Journal of Gastroenterology2008，14，42：	2
2	Patients with pertrochanteric hip fracture may benefit fron preoperative intravenous iron therapy: a pilot study 显示文摘	Cuenca J Garcia Erce JA Munoz M	2004	Transfusion2004，44，：	1
3	Epidemiology and cost of herpes zoster and postherpetic neu? ralgia among patients treated in primary care centres in the valen? cian community of Spain显示文摘	Cebrian - Cuenca AM Diez - Domingo J San - Martin - Ro- driguez M	2011	BMC Intect Dis2011，11，5：	1
4	Flavonoids from Inula viscosa 显示文摘	Grande M Piera F Cuenca A	1985	Planta Med1985，51，4：	1
5	Scopulariopsis brevicaulis , a fungal pathogen resistant to broad- spectrum antifungal agents 显示文摘	Cuenca - Estrella M Gomez - Lopez A Mellado E	2003	Antimicrob Agents Chemother2003，47，7：	1
6	Marchetti nailing of closed fresh humeral shaftfractures显示文摘	Martinez A A Malillos M Cuenca J	2004	Chir Main2004，23，5：	1
7	Vitamin D insufficiency together with high serum levels of vita- min A increases the risk for osteoporosis in postmenopausal women显示文摘	Mata - Granados J M Cuenca - Acevedo JR Luque de Castro MD	2013	Arch Osteoporos2013，8，12：	1
8	Adenosine reverses a preestablished CC14 - induced micronodular cirrhosis through enhancing eollagenolytic aeivity and stimulating hepatocyte cell proliferation in rats 显示文摘	HERNANDEZ MUAOZ R DIAZ MUAOZ M SUAREZ CUENCA J A	2001	Hepatology2001，34，41：	1
9	A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma 显示文摘	Cuenca AG Delano M J Kelly-Scumpia KM	2011	Mol Med2011，17，34：	1
10	A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma显示文摘	Cuenca A G Delano M J Kelly-Scumpia K M	2011	Mol Med2011，17，34：	1
11	Surface deformation induced by water influx in the abandoned coal mines in Limburg,The Netherlands observed by satellite radar interferometry显示文摘	Caro Cuenca M Hooper A J Hanssen R F	2013	Journal of Applied Geophysics2013，88，：	1
12	Hybrid E-tongue for the evaluation of sweetness and bitterness of soft drinks fortified with epigallocatechin gallate显示文摘	Bulbarello A Cuenca M Schweikert L Mannino S Scampicchio M		0，，：	1
13	clinical features and epidemiology of Acinetobacter baumannii colo nization and infection in Spanish hospitals 显示文摘	Rodrguez - Bano J Cisneros J M Fernandez - cuenca F	2004	Infect control hosp epidemiol2004，25，10：	1
14	Tumoral markers in liver cirrhosis and hepatocellularcarcinoma显示文摘	Gomez R M Cuenca M B Dominguez M	2005	Gastroenterol Hepatol2005，28，：	1
15	ARelationship between beta-lactamase production,outer membrane protein and penicillin-binding protein profiles on the activity of carbapenems against clinical isolates of Acinetobacter baumannii显示文摘	Fernandez Cuenca F Martinez Martinez L Conejo M C	2003	J Antimicrob Chemother2003，51，3：	1
16	Helical CT without contrast in choledocholithiasis diagnosis 显示文摘	Jiménez Cuenca I del Olmo Martfnez L Pérez Homs M	2001	Eur Radiol2001，11，2：	1
17	Epidemiological and clinical features associated with colonisation/in- fection by Acinetobacter baumannii with phenotypic heterogeneous re- sistance to carbapenems显示文摘	Femandez - Cuenca F Gomez - Sdnchez M Rodriquez - Bario J	2013	Int J Antimicrob Agents2013，40，3：	1
18	Patients with pertrochanteric hip fracture may benefit from preoperative intravenous iron therapy:A pilot study显示文摘	Cuenca J García-Erce JA Mu(n)oz M		0，，：	1
19	Update on the epidemiology and diagnosis of invasive fungalinfection显示文摘	Cuenca Estrella M Bernal-Martinez L Buitrago MJ	2008	Int J Antimicrob Agents2008，322，：	1
20	Tumoral markers in liver Cirrhosis and hepatocellular CarCinoma显示文摘	GOMEZ RUBIO M de CUENCA MORON B DOMINGUEZ M	2005	GastrOenterol Hepatol2005，28，5：	1

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