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| 1 | Covalently closed-circular hepatitis B virus DNA reduction with entecavir or lamivudine显示文摘AIM: To investigate the reduction in hepatitis B virus(HBV) covalently closed-circular DNA(ccc DNA) with entecavir(ETV) or lamivudine(LAM). METHODS: This analysis included patients who had participated in the randomized Phase Ⅲ study ETV-022 comparing ETV vs LAM in nucleos(t)ide-naive, HBe Agpositive patients. Patients received ETV(0.5 mg daily) or LAM(100 mg daily) for a minimum of 52 wk. Patients were eligible to participate in this sub-study if they had paired biopsies at baseline and week 48 with evaluable measurements for hepatic HBV ccc DNA and total hepatic HBV DNA. The main objective was to compare changes in hepatic HBV ccc DNA and total hepatic HBV DNA at week 48 of ETV or LAM treatment, which was a secondary endpoint of study ETV-022. Additional post hoc analyses included linear regression analyses to assess associations of baseline levels and on-treatment changes of ccc DNA with other baseline factors [sex,age, serum HBV DNA, alanine aminotransferase(ALT), Knodell necroinflammatory score, Ishak fibrosis score, total hepatic HBV DNA, and HBV genotype], or ontreatment factors(changes from baseline at week 48 in serum HBV DNA, ALT, Knodell necroinflammatory score, Ishak fibrosis score, total hepatic HBV DNA, and HBe Ag loss at week 48).RESULTS: Overall, 305 patients(ETV = 159; LAM = 146) of ETV-022 had paired baseline and week 48 liver biopsies with evaluable measurements for hepatic HBV ccc DNA and total hepatic HBV DNA, and were included in this analysis. Baseline demographics and disease characteristics were comparable between the two arms. After 48 wk, ETV resulted in significantly greater reductions in hepatic HBV ccc DNA [-0.9 log10 copies/human genome equivalent(HGEq) vs-0.7 log10 copies/HGEq; P = 0.0033] and total hepatic DNA levels(-2.1 log10 copies/HGEq vs-1.6 log10 copies/HGEq; P < 0.0001) than LAM. Virologic, biochemical, and histologic response rates at week 48 were also greater with ETV than with LAM. Baseline HBV ccc DNA levels were positively associated with baseline levels of serum HBV DNA and total hepatic HBV DNA, and negatively associated with HBV genotype F. On-treatment changes in HBV ccc DNA levels were negatively associated with baseline levels of serum HBV DNA and baseline ALT, and were positively associated with on-treatment changes in the levels of serum HBV DNA, total hepatic HBV DNA levels, and ALT, change in Knodell necroinflammatory score, and HBe Ag loss.CONCLUSION: Forty-eight weeks of ETV resulted in greater reductions in ccc DNA and total hepatic HBV DNA than LAM, but long-term therapy may be needed for ccc DNA elimination. | Scott Bowden Stephen Locarnini Ting-Tsung Chang You-Chen Chao Kwang-Hyub Han Robert G Gish Robert A de Man Miao Yu Cyril Llamoso Hong Tang | 2015 | World Journal of Gastroenterology2015，21，15： | 11 |
| 2 | 3D palaeogeographic reconstructions of the Phanerozoic versus sea-level and Sr-ratio variations显示文摘A full global geodynamical model over 600 million years(Ma) has been developed at the University of Lausanne during the past 20 years. We show herein how the 2D maps were converted into 3D(i.e., full hypsometry and bathymetry), using a heuristic-based approach. Although the synthetic topography may be viewed as relatively crude, it has the advantage of being applicable anywhere on the globe and at any geological time. The model allows estimating the sea-level changes throughout the Phanerozoic, with the possibility, for the first time, to flood accordingly continental areas. One of the most striking results is the good correlation with 'measured' sea-level changes, implying that long-term variations are predominantly tectonically-driven. Volumes of mountain relief are also estimated through time and compared with strontium isotopic ratio(Sr-ratio), commonly thought to reflect mountain belt erosion. The tectonic impact upon the general Sr-ratio trend is shown herein for the first time, although such influence was long been inferred. | Christian Vérard Cyril Hochard Peter O.Baumgartner Gérard M.Stampfli | 2015 | Journal of Palaeogeography2015，4，1： | 7 |
| 3 | Geodynamic evolution of the Earth over the Phanerozoic:Plate tectonic activity and palaeoclimatic indicators显示文摘During the last decades, numerous local reconstructions based on field geology were developed at the University of Lausanne(UNIL). Team members of the UNIL participated in the elaboration of a 600 Ma to present global plate tectonic model deeply rooted in geological data, controlled by geometric and kinematic constraints and coherent with forces acting at plate boundaries.In this paper, we compare values derived from the tectonic model(ages of oceanic floor, production and subduction rates, tectonic activity) with a combination of chemical proxies(namely CO2, 87Sr/86 Sr, glaciation evidence, and sea-level variations) known to be strongly influenced by tectonics. One of the outstanding results is the observation of an overall decreasing trend in the evolution of the global tectonic activity, mean oceanic ages and plate velocities over the whole Phanerozoic. We speculate that the decreasing trend reflects the global cooling of the Earth system. Additionally, the parallel between the tectonic activity and CO2 together with the extension of glaciations confirms the generally accepted idea of a primary control of CO2 on climate and highlights the link between plate tectonics and CO2 in a time scale greater than 107 yr. Last, the wide variations observed in the reconstructed sea-floor production rates are in contradiction with the steady-state model hypothesized by some. | Christian Vérard Cyril Hochard Peter O.Baumgartner Gérard M.Stampfli | 2015 | Journal of Palaeogeography2015，4，2： | 6 |
| 4 | 动态^(18)F-FDG PET定量分析用于骨病变鉴别诊断显示文摘目的 评价18F 脱氧葡萄糖 (FDG)PET在骨骼病变中的诊断价值。方法 研究对象为40例原发性骨骼病变患者。所有患者在注射示踪剂后立即开始动态PET采集 ,持续 6 0min。对动态PET图像进行半定量分析 ,分别计算平均和最大标准摄取值 (SUVaver和SUVmax) ,病灶SUV/肌肉SUV比值 (T/M) ,病灶 6 0minSUV/ 30minSUV比值 (SUVaver 60 /3 0min和SUVmax 60 /3 0min)等。采用Patlak作图分析法对动态图像数据进行拟合计算 ,得出摄入常数 (Ki) ,计算FDG代谢率 (MRFDG)。根据接受器工作特性曲线 (ROC)确定各定量指标的诊断阈值 ,并比较其鉴别良恶性病变的灵敏度和特异性。结果 经病理检查证实恶性病变 2 1例 ,良性病变 19例。恶性病变的MRFDG和SUV值高于良性病变 ,但各种指标的数值分布均存在交叉重叠。SUVaver与MRFDG呈正相关 (r=0 6 7)。以SUV值≥ 1 8作为阈值时 ,鉴别良恶性病变的灵敏度和特异性分别为 85 0 %和 82 4% ,以MRFDG(1 1)为阈值时的灵敏度 (82 4% )与SUV相近 ,而特异性 (92 9% )较高。同时采用SUV(1 8)和SUVaver 60 /3 0min(1 1)作为鉴别标准时 ,较之单独采用SUV特异性可改善为 93 3% ,灵敏度略有降低 (81 3% )。结论 骨骼良恶性病变之间存在葡萄糖代谢率差异。单用静态FDGPET获取SUV值不能很好鉴? | 吴华 Antonia Dimitrakopoulou-Strauss Thomas O-Heichel Burkhard Lehner Ludger Bernd Volker Ewerbeck Cyrill Burger Ludwig G Strauss | 2002 | 中华核医学杂志2002，22，2： | 3 |
| 5 | The brain-specific tissue-type plasminogen activator inhibitor, neuroserpin, protects neurons against excitotoxicity both in vitro and in vivo显示文摘 | Nathalie Lebeurrier Géraldine Liot José P. Lopez-Atalaya Cyrille Orset Monica Fernandez-Monreal Peter Sonderegger Carine Ali Denis Vivien | 2005 | Molecular and Cellular Neuroscience2005，，4： | 1 |
| 6 | Empirical estimation of tail dependence using Copulas application to Asian mar- kets 显示文摘 | CYRIL C DOMINIQUE G | 2005 | Quantitative Finance2005，，5： | 1 |
| 7 | Near-perfect elastoplasticity in pure nanocrystalline copper 显示文摘 | Yannick C Cyril L Sandrine G M | 2003 | Science2003，300，56： | 1 |
| 8 | Empirical estimation of tail correlation using copulas:application to Asian markets显示文摘 | Cyril C Dominique M G | 2005 | Quantitative Finance2005，5，5： | 1 |
| 9 | Near-perfect elastoplasticity in pure nanocrystalline copper 显示文摘 | YANNICK C CYRIL L SANDRINE G M | 2003 | Science2003，300，5617： | 1 |
| 10 | An overview of toxins and genes from the venom of the Asian scorpion Buthus martensi Karsch显示文摘 | Cyril G Cheng-Wu C Jan T | 2002 | Toxicon2002，40，9： | 1 |
| 11 | TPR study on the preparation of impregnated Co/SiO2 catalysts显示文摘 | ERIC V S SEWELL G S MAKHOTHE R A MAKHOTHE CRAIG M HEIKO M MARTIJIN D L CYRIL T O | 1996 | J Catal1996，162，2： | 1 |
| 12 | Interaction of PRMT1 with BIG/TOB proteins in cell signalling : molecular analysis and functional aspects 显示文摘 | Cyril B Fabienne G Valerie R | 2002 | Genes Cells2002，7，： | 1 |
| 13 | Bridging the gap between fea- ture and grid-based SLAM 显示文摘 | KAI M W CYRILL S GIORGIO G | 2010 | Robotics and Autonomous Sys- tems2010，58，2： | 1 |
| 14 | Changes in membrane polar lipid fatty aeids of seashore paspalum in response to low temperature exposure显示文摘 | Cyril J Powell G L Luncan R R | 2002 | Crop Sci2002，42，： | 1 |
| 15 | Changes in membrane polar lipid fatty acids of seashore paspalum in response to low temperature exposure显示文摘 | Cyril J Powell G L Luncan R R | 2002 | Crop Sci2002，42，： | 1 |
| 16 | Changes in membrane polar lipid fatty acids of seashore paspalum in response to low temperature exposure显示文摘 | Cyril J Powell G L Duncan R R | 2002 | Crop Science2002，42，： | 1 |
| 17 | Changes in membrane polar lipid fatty acids of seashore paspalum in response to low temperature exposure显示文摘 | Cyril J Powell G L Duncan R R | 2002 | Crop Science2002，42，6： | 1 |
| 18 | A qualitative examination of factors affecting reverse logistics systems for end-of-life computers 显示文摘 | IA Michael Knemeyer Thomas G Ponzurick Cyril M Logar | 2002 | International Journal of Physical Distribution & Logistics Management2002，32，6： | 1 |
| 19 | Design and synthesis of new polyphosphorylated upper-rim modifiedcalix arenes as potential and selective chelating agents ofuranyl ion显示文摘 | Evelyne M G Cyrille M Ramon B | 2008 | Tetrahedron2008，65，： | 1 |
| 20 | Changes in membrane polar lipid fatty acids of seashore paspalum in response to low temperature exposure 显示文摘 | CYRIL J POWELL G L DUNCAN R R | 2002 | Crop Sci2002，，42： | 1 |
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