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| 1 | Endoscopy-based management decreases the risk of postoperative recurrences in Crohn's disease显示文摘AIM: To investigate whether an endoscopy-based management could prevent the long-term risk of postoperative recurrence.METHODS: From the pathology department database, we retrospectively retrieved the data of all the patients operated on for Crohn's disease(CD) in our center(1986-2015). Endoscopy-based management was defined as systematic postoperative colonoscopy(median time after surgery = 9.5 mo) in patients with no clinical postoperative recurrence at the time of endoscopy. RESULTS: From 205 patients who underwent surgery, 161 patients(follow-up > 6 mo) were included. Endoscopic postoperative recurrence occurred in 67.6%, 79.7%, and 95.5% of the patients, respectively 5, 10 and 20 years after surgery. The rate of clinical postoperative recurrence was 61.4%, 75.9%, and 92.5% at 5, 10 and 20 years, respectively. The rate of surgical postoperative recurrence was 19.0%, 38.9% and 64.7%, respectively, 5, 10 and 20 years after surgery. In multivariate analysis, previous intestinal resection, prior exposure to anti-TNF therapy before surgery, and fistulizing phenotype(B3) were postoperative risk factors. Previous perianal abscess/fistula(other perianal lesions excluded), were predictive of only symptomatic recurrence. In multivariate analysis, an endoscopy-based management(n = 49/161) prevented clinical(HR = 0.4, 95%CI: 0.25-0.66, P < 0.001) and surgical postoperative recurrence(HR = 0.30, 95%CI: 0.13-0.70, P = 0.006).CONCLUSION: Endoscopy-based management should be recommended in all CD patients within the first year after surgery as it highly decreases the long-term risk of clinical recurrence and reoperation. | Anne-Laure Boucher Bruno Pereira Stéphanie Decousus Marion Goutte Felix Goutorbe Anne Dubois Johan Gagniere Corinne Borderon Juliette Joubert Denis Pezet Michel Dapoigny Pierre J Déchelotte Gilles Bommelaer Anthony Buisson | 2016 | World Journal of Gastroenterology2016，22，21： | 3 |
| 2 | Assessment of large aperture lightweight imaging concepts 显示文摘 | BELL K D BOUCHER R H | 1999 | IEEE1999，，： | 3 |
| 3 | Health-related quality of life after short segment instrumentation of lumbar burst fractures显示文摘 | Boucher M Bhandari M Kwok D | 2001 | J Spinal Disord2001，14，5： | 1 |
| 4 | Apelin,a newly identified adipokine up-regulated by insulin and obesity显示文摘 | Boucher J Masri B Daviaud D | 2005 | Endocr inology2005，146，4： | 1 |
| 5 | Apelin, a newly identified adipoklne up-regulated by insulin and obesity 显示文摘 | Boucher J Masri B Dviaud D | 2004 | Endocrinology2004，146，4： | 1 |
| 6 | Double cortin is a developmentally regulated,microtubule-associated protein expressed in migrating and differentiating neurons显示文摘 | Francis F Koulakoff A Boucher D | 1999 | Neuron1999，23，2： | 1 |
| 7 | Annexin V binding to plas- ma membrane predicts the quality of human cryopreserved spermatozoa显示文摘 | Sion B Janny L Boucher D | 2004 | International Journal of Andrology2004，27，： | 1 |
| 8 | Growth and physiological response of eastern white pine seedlings to partial cutting and site preparation显示文摘 | Boucher J F Bernier P Y Margolis H A Munson A D | | 0，，： | 1 |
| 9 | 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort 显示文摘 | Hypponen E Boucher B J Berry D J | 2008 | Diabetes2008，57，2： | 1 |
| 10 | Apelin, a newly identified adi- pokine up-regulated by insulin and obesity 显示文摘 | Boucher J Masri B Daviaud D | 2005 | Endocrinology2005，146，19： | 1 |
| 11 | Epidemiology and susceptibility of pathogenic bacteria responsible for upper respiratory tract infections in pet rabbits显示文摘 | Rougier S Galland D Boucher S | 2006 | Vet Microbiol2006，115，13： | 1 |
| 12 | The kinetics and mechanism of the oxidation of 1,4-thioxane by potassium ferrate显示文摘 | Boucher K D Mehlman S A | 1998 | Inorganica Chim Acta1998，267，1： | 1 |
| 13 | Skew cyclic code显示文摘 | Boucher D Geiselmann W Ulmer F | 2007 | Applied Algebra in Engineering Communication and Com- puting2007，18，4： | 1 |
| 14 | Effect of wine ethanol on serum iron and ferritin levels in patients with coronary heart disease 显示文摘 | de Lorgeril M Salen D Boucher F | 2001 | Nutr Metab Cardiovasc Dis2001，11，3： | 1 |
| 15 | Apelin,a newly identified adipokine up-regulated by insulin and obesity显示文摘 | Boucher J Masri B Daviaud D | 2005 | Endocrinology2005，146，4： | 1 |
| 16 | Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth:involvement of transforming growth factor β1显示文摘 | Gohongi T Fukumura D Boucher Y | 1999 | Nat Med1999，5，： | 1 |
| 17 | Effects of trimetazidine on ischemic contracture in isolatecl perfused rat hearts显示文摘 | Boucher F R Hearse D J Opie L H | 1994 | J Cardiovasc Pharmacol1994，24，1： | 1 |
| 18 | Apehn, a newly identified adipokine up-regulated by insulin and obesity显示文摘 | Boucher J Masri B Daviaud D | 2005 | Endocrinology2005，146，4： | 1 |
| 19 | Empirical methods for controlling false positives and estimating confidence in ChlP-Seq peaks 显示文摘 | Nix D A Courdy S J Boucher K M | 2008 | BMC Bioinformatics2008，，9： | 1 |
| 20 | Serum concentrations, efficacy, and safety of a new, intravenously administel'ed varicella zoster immune globulin in pregnant women显示文摘 | Koren G Money D Boucher M | 2002 | J Clin Pharmacol2002，42，3： | 1 |
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