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| 1 | Diagnosis of gastrointestinal bleeding: A practical guide for clinicians显示文摘Gastrointestinal bleeding is a common problem encountered in the emergency department and in the primary care setting. Acute or overt gastrointestinal bleeding is visible in the form of hematemesis, melena or hematochezia. Chronic or occult gastrointestinal bleeding is notapparent to the patient and usually presents as positive fecal occult blood or iron deficiency anemia. Obscure gastrointestinal bleeding is recurrent bleeding when the source remains unidentified after upper endoscopy and colonoscopic evaluation and is usually from the small intestine. Accurate clinical diagnosis is crucial and guides definitive investigations and interventions. This review summarizes the overall diagnostic approach to gastrointestinal bleeding and provides a practical guide for clinicians. | Bong Sik Matthew Kim Bob T Li Alexander Engel Jaswinder S Samra Stephen Clarke Ian D Norton Angela E Li | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 13 |
| 2 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 3 | Role of autophagy in differential sensitivity of hepatocarcinoma cells to sorafenib显示文摘AIM: To investigate the role of sorafenib(SFN) in autophagy of hepatocellular carcinoma(HCC). We evaluated how SFN affects autophagy signaling pathway in human HCC cell lines. METHODS: Two different human HCC cell lines, Hep3 B and Huh7, were subjected to different concentrations of SFN. Cell viability and onset of apoptosis were determined with colorimetric assay and immunoblotting analysis, respectively. The changes in autophagy-related proteins, including LC3, ULK1, AMPK, and LKB, were determined with immunoblotting analysis in the presence or absence of SFN. To assess autophagic dynamics, autophagic flux was measured with chloroquine, a lysosomal inhibitor. The autophagic responsiveness between different HCC cell lines was compared under the autophagy enhancing conditions.RESULTS: Hep3 B cells were significantly more resistant to SFN than Huh7 cells. Immunoblotting analysis revealed a marked increase in SFN-mediated autophagy flux in Huh7 cells, which was, however, absent in Hep3 B cells. While both starvation and rapamycin enhanced autophagy in Huh7 cells, only rapamycin increased autophagy in Hep3 B cells. Immunoblotting analysis of autophagy initiation proteins showed that SFN substantially increased phosphorylation of AMPK and consequently autophagy in Huh7, but not in Hep3 B cells.CONCLUSION: The autophagic responsiveness to SFN is distinct between Hep3 B and Huh7 cells. Resistance of Hep3 B cells to SFN may be associated with altered autophagy signaling pathways. | Trevan D Fischer Jin-Hee Wang Adrian Vlada Jae-Sung Kim Kevin E Behrns | 2014 | World Journal of Hepatology2014，6，10： | 5 |
| 4 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 5 | Treatment of hypogonadotropic male hypogonadism: Case-based scenarios显示文摘The aim of this study is to review four case-based scenarios regarding the treatment of symptomatic hypogonadism in men. The article is designed as a review of published literature. We conducted a Pub Med literature search for the time period of 1989-2014, concentrating on 26 studies investigating the efficacy of various therapeutic options on semen analysis, pregnancy outcomes, time to recovery of spermatogenesis, as well as serum and intratesticular testosterone levels. Our results demonstrated that exogenous testosterone suppresses intratesticular testosterone production, which is an absolute prerequisite for normal spermatogenesis. Cessation of exogenous testosterone should be recommended for men desiring to maintain their fertility. Therapies that protect the testis involve human chorionic gonadotropin(h CG) therapy or selective estrogen receptor modulators(SERMs), but may also include low dose h CG with exogenous testosterone. Off-label use of SERMs, such as clomiphene citrate, are effective for maintaining testosterone production long-term and offer the convenience of representing a safe, oral therapy. At present, routine use of aromatase inhibitors is not recommended based on a lack of longterm data. We concluded that exogenous testosterone supplementation decreases sperm production. It was determined that clomiphene citrate is a safe and effective therapy for men who desire to maintain fertility. Although less frequently used in the general population, h CG therapy with or without testosterone supplementation represents an alternative treatment. | Lindsey E Crosnoe-Shipley Osama O Elkelany Cyrus D Rahnema Edward D Kim | 2015 | World Journal of Nephrology2015，4，2： | 3 |
| 6 | Growth factors for fetal and adult human astrocytes in culture显示文摘 | Yong V W Kim S U Pleasure D E | 1998 | Brain Res1998，444，1： | 2 |
| 7 | Molecular biology of cervical myelopathy and spinal cord injury:role of oligodendrocyte apoptosis显示文摘 | Kim D H Vaccaro A R Henderson F C Benzel E C | 2003 | Spine J2003，3，： | 1 |
| 8 | Periodic mesoporous organosilicas with multiple bridging groups and spherical morphology显示文摘 | CHO E B KIM D JARONIEC M | 2007 | Langmuir2007，23，11： | 1 |
| 9 | An optimization model for signal timings and alternate lane use at a signalized intersection显示文摘 | Hong S Shin E Kim D N | 2003 | Journal of the Eastern Asia Society for Transportation Studies2003，5，： | 1 |
| 10 | Berberine activates GLUT1-mediated glueose uptake in 3T3-L1 adipoeytes显示文摘 | KIM S H SHIN E J KIM E D | 2007 | Biol Pharm Bull2007，30，： | 1 |
| 11 | Gas-phase dehydration of glycerol over ZSM-5 catalysts显示文摘 | KIM Y T JUNG K D PARK E D | 2010 | Microporous and Mesoporous Materials2010，131，13： | 1 |
| 12 | Pegylated li- posomal doxorubicin HCL (PLD; Caelyx/Doxil): experience with long-term maintenance in responding patients with recurrent ep- ithelial ovarian cancer显示文摘 | ANDREOPOULOU E GAIOTYI D KIM E | 2007 | Ann Oneol2007，18，4： | 1 |
| 13 | Computational Implemen- tation of Asymmetric Integral Imaging by Use of Two Crossed Lenticular Sheets显示文摘 | Shin D H Cho M Kim E S | 2005 | ETRI J2005，27，： | 1 |
| 14 | Effect of BaWO4 on the microwave dielectric properties of Ba(Mg1/3 Ta2/3 )O3 ceramics显示文摘 | YOON K H KIM D P KIM E S | 1994 | J Am Ceram Soc1994，77，4： | 1 |
| 15 | Tolerance to toxic metals by a gene family of phytochelatin synthases from plants and yeast显示文摘 | CLEMENS S KIM E J NEUMANN D | 1999 | EMBO J1999，18，： | 1 |
| 16 | Comparison of AI-Cu-Fe quasierystalline particle reinforced AI composites fabricated by conventional casting and extrusion显示文摘 | Fleury E Lee S M Choi G Kim W T Kim D H | 2001 | J Mater Sci2001，36，： | 1 |
| 17 | Regulation of ILlheta-mediated MUC2 gene in NCI-H292 human airway epithelial cells显示文摘 | Kim Y D Kwon E J Raque G H | 2000 | Biochem Biophys Res Commum2000，274，5： | 1 |
| 18 | The plant community of Nanjido,a representative nonsanitary landfill in south Korea : Implicationsfor restoration alternatives 显示文摘 | Kim K D Lee E J Cho K H | 2003 | Water Air and Soil Pollution2003，154，14： | 1 |
| 19 | Ventricular diverticula on cardiac CT: more common than previously thought显示文摘 | SRICHAI M B HECHT E M KIM D C | 2007 | Am J Roentgenol2007，189，2： | 1 |
| 20 | Design and optimization of an LPG roller vane pump for suppressing cavitation 显示文摘 | Danardono D Kim K S Roziboyev E | 2010 | International Journal of Automobile Technology2010，11，3： | 1 |
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