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| 1 | Alcoholic pancreatitis:New insights into the pathogenesisand treatment显示文摘Acute pancreatitis is a necro-inflammatory disease of the exocrine pancreas that is characterized by inappropriate activation of zymogens, infiltration of the pancreas by inflammatory cells, and destruction of the pancreatic exocrine cells. Acute pancreatitis can progress to a severe life-threatening disease. Currently there is no pharmacotherapy to prevent or treat acute pancreatitis. One of the more common factors associated with acute pancreatitis is alcohol abuse. Although commonly associated with pancreatitis alcohol alone is unable to cause pancreatitis. Instead, it appears that alcohol and its metabolic by-products predispose the pancreas to damage from agents that normally do not cause pancreatitis, or to more severe disease from agents that normally cause mild pancreatic damage. Over the last 10 to 20 years, a tremendous amount of work has defined a number of alcohol-mediated biochemical changes in pancreatic cells. Among these changes are: Sustained levels of intracellular calcium, activation of the mitochondrial permeability transition pore, endoplasmic reticulum stress, impairment in autophagy, alteration in the activity of transcriptional activators, and colocalization of lysosomal and pancreatic digestive enzymes. Elucidation of these changes has led to a deeper understanding of the mechanisms by which ethanol predisposes acinar cells to damage. This greater understanding has revealed a number of promising targets for therapeutic intervention. It is hoped that further investigation of these targets will lead to the development of pharmacotherapy that is effective in treating and preventing the progression of acute pancreatitis. | Dahn L Clemens Katrina J Schneider Christopher K Arkfeld Jaclyn R Grode Mark A Wells Shailender Singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 10 |
| 2 | Alcoholic pancreatitis:Lessons from the liver显示文摘The association between alcohol consumption and pancreatitis has been recognized for over 100 years. Despite the fact that this association is well recognized, the mechanisms by which alcohol abuse leads to pancreatic tissue damage are not entirely clear. Alcohol abuse is the major factor associated with pancreatitis in the Western world. Interestingly, although most cases of chronic pancreatitis and many cases of acute pancreatitis are associated with alcohol abuse, only a small percentage of individuals who abuse alcohol develop this disease. This situation is reminiscent of the association between alcohol abuse and the incidence of alcoholic liver disease. The liver and the pancreas are developmentally very closely related. Even though these two organs are quite different, they exhibit a number of general structural and functional similarities. Furthermore, the diseases mediated by alcohol abuse in these organs exhibit some striking similarities. The diseases in both organs are characterized by parenchymal cell damage, activation of stellate cells, aberrant wound healing, and fibrosis. Because of the similarities between the liver and the pancreas, and the alcohol-associated diseases of these organs, we may be able to apply much of the knowledge that we have gained regarding the effects of alcohol on the liver to the pancreas. | Dahn L Clemens Katrina J Mahan | 2010 | World Journal of Gastroenterology2010，16，11： | 5 |
| 3 | Electrochemistry of in Sb as a Li insertion host:problems and prospects显示文摘 | HEWITT K C BEAULIEU L Y DAHN J R | 2001 | J Electrochem Soc2001，148，： | 1 |
| 4 | The reaction of lithium with Sn-Mn-C intermetallics prepared by mechanical alloying显示文摘 | BEAULIEU L Y DAHN J R | 2000 | J Electrochem Soc2000，147，： | 1 |
| 5 | Layered Li-Mn-Oxide with the O2 Structure: A cathode material for Li-ion cells which does not convert to spinel 显示文摘 | PAULSEN J M THOMAS C L DAHN J R | 1999 | Journal of The Electrochemical Social1999，146，10： | 1 |
| 6 | Spectroelectrochemical studies of redox shuttle overcharge additive for LiFePO4-based Li-ion batteries显示文摘 | Moshurchak L M Buhrmester C Dahn J R | 2005 | J Eletrochem Soc2005，152，： | 1 |
| 7 | High-rate overcharge protection of LiFePO4-based Li-ion cells using the redox shuttle additive 2,5-ditertbuty-1,4-dimethoxybenzene显示文摘 | Dahn J R Jiang J Moshurchak L M | 2005 | J Eletrochem Soc2005，152，： | 1 |
| 8 | Calculations of oxidation potentials of redox shuttle additives for Li-ion cells 显示文摘 | WANG R L BUHRMESTER C DAHN J R | 2006 | J Electrochem Soc2006，153，2： | 1 |
| 9 | High-stability bimorph scanning tunneling microscope显示文摘 | Blackford B L Dahn D C Jericho M H | 1987 | Rev Sci Instrum1987，58，8： | 1 |
| 10 | First principlesstudies of silicon as a negative electrode material for lithium-ionbatteries显示文摘 | CHEVRIER V L ZWANZIGER J W DAHN J R | 2009 | Canadian Journal of Physics2009，87，： | 1 |
| 11 | Synthesis,structure,and electrochemical behavior of LiO2显示文摘 | LU Zhong-hua BEAULIEU L Y DONABERGER R A THOMAS C L DAHN J R | 2002 | Journal of the Electrochemical Society2002，149，6： | 1 |
| 12 | High-rate overcharge protection of LiFePO4-based Li-ion cells using the redox shuttle additive 2,5-ditertbuty-1,4-dimethoxybenzene显示文摘 | Dahn J R Jiang J Moshurchak L M | 2005 | Journal of the Electrochemical Society2005，152，： | 1 |
| 13 | Smart micro- and nanocontainers for storage, transport, and release 显示文摘 | Ibarz G Dahne L Donath E | 2001 | Adv Mater2001，3，： | 1 |
| 14 | Impact of Binder Choice on the Performance of a-Fe203 as a Negative Electrode 显示文摘 | Li J Dahn H M Krause L J' | 2008 | Journalof the Electrochemical Society2008，155，11： | 1 |
| 15 | High-Rate overcharge protection of LiFePO4-based Li-ion cells using the redox shuttle additive 2,5-ditertbutyl-1,4-dimethoxybenzene 显示文摘 | DAHN J R JIANG J W MOSHURCHAK L M | 2005 | J Electrochem Soc2005，152，6： | 1 |
| 16 | Comparison of PVDF and PVDF-TFE-P as binders for electrode materials showing large volume changes in lithium-ion batteries显示文摘 | Chen Z H Christensen L Dahn J R | 2003 | J Electrochem Soc2003，150，8： | 1 |
| 17 | 查看详情显示文摘 | Peyratout C.S Dahne L | | 0，，： | 1 |
| 18 | Antibioticresistant bacteria in pediatric chronic sinusitis显示文摘 | Slack C L Dahn K A Abzug M J | 2001 | Pediatr Infect Dis J2001，20，： | 1 |
| 19 | Layered Li-Mn-Oxide, with O2 Structure: A Cathode Material For Li-Ion Cell which Does Not Convert to Spinel 显示文摘 | Pauslsen J M Thomas C L Dahn J R | 1999 | J Electrochem Soc1999，146，10： | 1 |
| 20 | Effect of the sintering agent, B203, on LiO2 materials density, structure, and electrochemical properties显示文摘 | JOUANNEAU S BAHMET W EHERMAN K W KRAUSE L J DAHN J R | 2004 | Journal of the Electrochemical Society2004，151，11： | 1 |
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