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| 1 | Comparison of novel and standard diagnostic tools for the detection of Schistosoma mekongi infection in Lao People’s Democratic Republic and Cambodia显示文摘Background:Given the restricted distribution of Schistosoma mekongi in one province in Lao People’s Democratic Republic(Lao PDR)and two provinces in Cambodia,together with progress of the national control programmes aimed at reducing morbidity and infection prevalence,the elimination of schistosomiasis mekongi seems feasible.However,sensitive diagnostic tools will be required to determine whether elimination has been achieved.We compared several standard and novel diagnostic tools in S.mekongi-endemic areas.Methods:The prevalence and infection intensity of S.mekongi were evaluated in 377 study participants from four villages in the endemic areas in Lao PDR and Cambodia using Kato-Katz stool examination,antibody detection based on an enzyme-linked immunosorbent assay(ELISA)and schistosome circulating antigen detection by lateral-flow tests.Two highly sensitive test systems for the detection of cathodic and anodic circulating antigens(CCA,CAA)in urine and serum were utilized.Results:Stool microscopy revealed an overall prevalence of S.mekongi of 6.4%(one case in Cambodia and 23 cases in Lao PDR),while that of Opisthorchis viverrini,hookworm,Trichuris trichiura,Ascaris lumbricoides and Taenia spp.were 50.4%,28.1%,3.5%,0.3%and 1.9%,respectively.In the urine samples,the tests for CCA and CAA detected S.mekongi infections in 21.0%and 38.7%of the study participants,respectively.In the serum samples,the CAA assay revealed a prevalence of 32.4%,while a combination of the CAA assay in serum and in urine revealed a prevalence of 43.2%.There was a difference between the two study locations with a higher prevalence reached in the samples from Lao PDR.Conclusions:The CCA,CAA and ELISA results showed substantially higher prevalence estimates for S.mekongi compared to Kato-Katz thick smears.Active schistosomiasis mekongi in Lao PDR and Cambodia might thus have been considerably underestimated previously.Hence,sustained control efforts are still needed to break transmission of S.mekongi.The pivotal role of highly sensitive diagnostic assays in areas targeting elimination cannot be overemphasised. | Youthanavanh Vonghachack Somphou Sayasone Virak Khieu Robert Bergquist Govert Jvan Dam Pytsje THoekstra Paul L.A.M.Corstjens Beatrice Nickel Hanspeter Marti Jürg Utzinger Sinuon Muth Peter Odermatt | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 2 | Identification and removal of pol ymer and aggregate forming proteins in human plasma albumin preparations显示文摘 | Jensen LB Dam J TeisnerB | 1994 | Vox Sang1994，67，2： | 1 |
| 3 | Troear implantation metastasis after laparoscopy in patients with advanced ovarian caneer:ean the risk be reduced显示文摘 | Van Dam PA DeCtoedt J Tjalma WA | 1999 | Am J Obstet Gyneeol1999，181，3： | 1 |
| 4 | Parameter estimation of soil hydraulic functions using inverse modeling of transient outflow experiments显示文摘 | Hopmans J W Dam J C van Eching S O | 1994 | Trends in Hydrology1994，1，： | 1 |
| 5 | Diamondoid hydrocarbons as indicators ofoil cracking显示文摘 | DaM J E Moldowan J M Peters K Claypool G Rooney M Michael G Mellos M Kohnen M | 1999 | Nature1999，399，6： | 1 |
| 6 | Cognitive deficits after postoperative adjuvant chemotherapy for breast carci noma显示文摘 | SCHAGEN S B VAN DAM F S MULLER M J | 1999 | Cancer1999，85，3： | 1 |
| 7 | Cloned human snRNP proteins B and B'differ only in their carboxy-terminal part 显示文摘 | Dam A Winkel I Zijistra-Baalbergen J | 1989 | EMBO J1989，8，12： | 1 |
| 8 | Fluorochenfical intermediates, surfactants and their use in coatings 显示文摘 | De witte J Piessens G Dams R | 1995 | Surface coating international1995，78，2： | 1 |
| 9 | Displacement of the Earth's surface due to atmospheric loading: Effects on gravity and baseline measurements显示文摘 | Van Dam T M Wahr J | 1987 | J Geophys Res1987，92，： | 1 |
| 10 | Experimental analysis of thick blunt trailing-edge wind turbine airfoils显示文摘 | Baker J P Mayda E A van Dam C P | 2006 | Journal of Solar Energy Engineering2006，128，4： | 1 |
| 11 | Automatic morpbometriccartilage quantification in the medial tibial plateau from MRI for oste- oarthritis grading显示文摘 | Dam EB Folkesson J Pettersen PC | 2007 | Osteoarthr Cartilage2007，7，15： | 1 |
| 12 | Cyclic oxygenates:A new class of second-generation biofuels for diesel engines显示文摘 | Boot M Frijters P Luijten C Somers B Baert R Donkerbroek A Klein-Douwel R J H Dam N | | 0，，04： | 1 |
| 13 | Intraoperative sentinel node identification with technetium-99m -labeled nanocolloid in patients with cancer of the uterine cervix : a feasibility study 显示文摘 | van Dam PA Hauspy J Vanderheyden T | 2003 | Int J Gynecol Cancer2003，13，2： | 1 |
| 14 | Formation, stability, and properties of in-situ composites based on blends of a thermotropic liquid crystalline polymer and a thermoplastic elastomer显示文摘 | Machiels A G C Denys K F J Van Dam J | 1996 | Polym Eng Sci1996，36，19： | 1 |
| 15 | Formation, Stability, and Properties of In-situ Composites Based on Blends of a Thermotropic Liquid Crystalline Polymer and a Thermoplastic Elastomer显示文摘 | A G C Machiels K F J Denys J Van Dam A P D Boer | 1996 | Polymer Engineering and Science1996，36，19： | 1 |
| 16 | Crustal displacements due to continental water loading显示文摘 | Van Dam T Wahr J Milly P C D | 2001 | Geophysical Research Letters2001，28，4： | 1 |
| 17 | Long term angiographic and clini- cal follow up in patients with stent implantation for symptomatic myocardial bridging 显示文摘 | Haager PK Schwarz ER vom DaM J | 2000 | Heart2000，84，： | 1 |
| 18 | IR Seeker Simulator and IR Scene Generation to Evaluate IR Decoy Effectiveness显示文摘 | Wim de Jong Frans A M Dam Gerard J Kunz | 2004 | SPIE Technologies for Optical Countermeasures2004，5615，： | 1 |
| 19 | A Coded Checklist and Ecological Indicator Values of Freshwater Diatoms from the Netherlands 显示文摘 | VAN DAM H MERTENS A SINKELDAM J | 1994 | Netherlands Journal of Aquatic Ecology1994，28，1： | 1 |
| 20 | Phase II randomized study of neoadjuvant everolimus plus letrozole compared with pla- cebo plus letrozole in patients with estrogen receptor - positive breast cancer 显示文摘 | Baselga J Semiglazov V Van Dam P | 2009 | J Clin Oncol2009，27，16： | 1 |
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