|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | The HITRAN 2008 molecular spectroscopic database 显示文摘 | Rothman L S Gordon I E Barbe A ChrisBenner D Bernath P F Birk M Boudon V Brown L R Campargue A Champi-on J P Chance K Coudert L H Dana V Devi V M Fally S Flaud J M Gamache R R Goldman A Jacquemart D Klein er I Lacome N Lafferty W J Mandin J Y Massie S T Mikhailenko S N Miller C E Moazzen A N Naumenko 0 VNikitin A V Orphal J Perevalov V I Perrin A Predoi C A Rinsland C P Rotger M ime kovd M Smith M A H Sung K Tashkun S A Tennyson J Toth R A Vandaele A C Vander A J | 2009 | Journal of Quantitative Spectroscopy Radiative Transfer2009，110，： | 1 |
| 3 | Design of homogeneous,monopegylated erythropoietin analogs with preserved in vitro bioactivlty显示文摘 | Dana L L Daniel H D Stephen P E | 2006 | Cox Exp Hematology2006，34，6： | 1 |
| 4 | Data transmission over networks for estimation and control显示文摘 | GUPTA V DANA A F HESPANHA J P | 2009 | IEEE Transactions on Automatic Control2009，54，8： | 1 |
| 5 | Twenty-five-year panorama of corneal immunology:emerging concepts in the immunopathogenesis of microbial keratitis,peripheral ulcerative keratitis, and corneal transplant rejection 显示文摘 | Dana MR Qian Y Hamrah P | 2000 | Cornea2000，19，5： | 1 |
| 6 | Governance mechanisms for the promotion of social capital for knowledge transfer in mul- tinational corporations 显示文摘 | Paul G Dana B M Torben P | 2011 | Journal of Management Studies2011，48，1： | 1 |
| 7 | Twenty-five year panorama of corneal immunology 显示文摘 | Dana MR Qian Y Hamrah P | 2000 | Cornea2000，19，5： | 1 |
| 8 | Point-target detection in IR image sequences based on target and clutter temporal profile modeling 显示文摘 | TZANNES Alexis P BROOKS Dana H | 1999 | SPIE1999，3698，： | 1 |
| 9 | Peroxisome proliferator-activated receptor subtype-specific regulation of hepatic and peripheral gene expression in the zucker diabetic fatty rats显示文摘 | Dana S T Hoener P A Bilakovics J M | 2001 | Metabolism2001，50，8： | 1 |
| 10 | Corneal antigen-presenting cells显示文摘 | Hamrah P Dana MR | 2007 | Chem Immunol Allergy2007，92，： | 1 |
| 11 | Contrasting Two Models of Wealth Redistribu-tion显示文摘 | Acs Z J Dana L P | 2001 | Small Business Economics2001，16，2： | 1 |
| 12 | Combining supramolecular chemistry with biology显示文摘 | Dana A U Kat J P Luc B | 2010 | Chem Soc Rev2010，，39： | 1 |
| 13 | Atmospheric Pressure Loading Corrections Applied to GPS Data at the Observation Level显示文摘 | Tregoning P van Dana T | 2005 | Geophys Res Lett2005，32，22： | 1 |
| 14 | Delamination resistant laminates by Zfiber pinning Ⅰ: manufacture and fracture performance显示文摘 | Dana K P CartiE D D R | 2005 | Composites Part A2005，36，1： | 1 |
| 15 | Delamination of Z-pinned carbon fibre reinforced laminates显示文摘 | CartiEd D R Troulis M Dana K P | 2006 | Composites Science and Technology2006，66，6： | 1 |
| 16 | The SELF-PRUNING gene of tomato regulates vegetative to reproductive switching of sympodial meristems and is the ortholog of CEN and TFL1显示文摘 | LILAC P LEA C DANA H | 1998 | Development1998，125，： | 1 |
| 17 | The form of the human dental arch显示文摘 | Stanley B William P Dana E | 1998 | Angle Orthod1998，68，： | 1 |
| 18 | Arginine synthesis is regulated by dietary arginine intake in the enterally fed neonatal piglet显示文摘 | Dana L W Bertolo R F P Brunton J A | 1994 | Biochemical Journal1994，299，： | 1 |
| 19 | The form of the human dental arch显示文摘 | Stanley B William P Dana E | 1998 | Angle Orthod1998，68，1： | 1 |
| 20 | Start-timing for calcium chloride spray programs influences fruit calcium and bitter pit in ‘Braebum' and ‘Honeycrisp' apples 显示文摘 | Frank J P Gerry H N Dana F | 2007 | 105 (1): 1213-12272007，105，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员