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| 1 | Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial显示文摘 | Stephen B Hanauer Brian G Feagan Gary R Lichtenstein Lloyd F Mayer S Schreiber Jean Frederic Colombel Daniel Rachmilewitz Douglas C Wolf Allan Olson Weihang Bao Paul Rutgeerts | 2002 | The Lancet2002，，9317： | 6 |
| 2 | pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus显示文摘AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P < 0.02). Loss of pRb expression increased in a stepwise fashion according to the severity of the histological findings (P < 0.005): normal mucosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). CONCLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy. | Simone S Contu Paulo C Contu Daniel C Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa Joo C Prolla Luis F Moreira | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 3 | 站立30s后直立性低血压与老年抑郁之间的纵向关系显示文摘直立性低血压(orthostatic hypotension,OH)与老年抑郁之间存在明确的横向联系。该观察性研究的目的是为了阐明基线症状性OH(symptomatic OH,sOH-30)与抑郁症之问的纵向关系。该样本包含无基线抑郁症的老年人(平均年龄62岁)〉3000名。 | Robert B Daniel C Sean PK Rose AK 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，5： | 2 |
| 4 | 2009年南极冰穹A的双色天光背景统计和分析显示文摘天光背景是天文台址的一个重要指标。利用2009年位于南极冰穹A的CSTAR望远镜两个波段的观测数据,对南极冰穹A的天光背景进行了统计和分析。结果表明约74%的g波段天光背景的ADU值小于每像素100/s;90.5%的r波段的天光背景的ADU值小于每像素100/s。在不考虑大气消光的情况下,定标后的结果为2009年冰穹A的观测数据中天光背景亮度的中值:g波段为19.9 mag/arcsec2,r波段为20.1 mag/arcsec2。 | 宗伟凯 付建宁 牛家树 Ashley Michael C B 宫雪非 Lawrence J S 刘强 Luong-Van Daniel Pennypacker C R Storey John W V 王灵芝 王力帆 杨惠根 袁祥岩 York Donald G 朱镇熹 | 2014 | 天文研究与技术2014，11，1： | 2 |
| 5 | Activitybased costing accounting for a market orientation 显示文摘 | Daniel J G Greg W M William B C | 1998 | Industrial Marketing Management1998，，127： | 1 |
| 6 | Oral glutamine in the prevention of fluomuracil induced intestinal toxicity: a double blind, placebo controlled, randomized trial显示文摘 | Daniele B Perrone F Gallo C | 2001 | Gut2001，48，1： | 1 |
| 7 | Measurement of scenic beauty :the law of comparative judgment and scenic beauty estimation proce-dures 显示文摘 | Hulliv H B Buhyoff G J Daniel T C | 1984 | Forest Science1984，30，4： | 1 |
| 8 | Gyroscope free strapdown inertial measurement unit by six linear accelerometers显示文摘 | Chen Jeng-heng Lee S C Daniel B | 1994 | Journal of Guidance Control and Dynamics1994，17，2： | 1 |
| 9 | Suppression of allergic immune responses to house dust mite (HDM) in rats exposed to 2,3,7,8-TCDD显示文摘 | Luebke R W Copeland C B Daniels M | 2001 | Toxicol Sci2001，62，1： | 1 |
| 10 | Gyroscope free strapdown inertial measurement unit by six linear accelerometers显示文摘 | Jeng-Heng Chen S C Lee Daniel B | 1994 | Journal of Guidance Control and Dynamics1994，17，2： | 1 |
| 11 | A form of albinism in cattle is caused by a tyrosinase frameshift mutation 显示文摘 | SHEILA M S TOM G B DANIEL C C | 2004 | MammalianGenome2004，15，： | 1 |
| 12 | Crohn,s disease显示文摘 | Daniel C B William J S | 2012 | Lancet2012，380，： | 1 |
| 13 | The evolution of a physiological system: the pulmonary surfactant system in diving mammals 显示文摘 | FOOT N J ORGEIG S DANIELS C B | 2006 | Respiratory Physiology & Neurobiology2006，154，1： | 1 |
| 14 | Lactobacillus species isolated from the vagina: identification, hydrogen peroxide production and nonoxynol-9 resistance显示文摘 | PASCUAL L M DANIELE M B PAJARO C | 2006 | Contraception2006，73，： | 1 |
| 15 | Second harmonic transthoracic echocardiography:The new reference screening method for the detection of patent foramen ovale显示文摘 | Daniels C Weytjens C Cosyns B | 2004 | Eur J Echocardiogr2004，5，6： | 1 |
| 16 | Conserva- tion of surfactant protein A: evidence for a single origin for vertebrate pulmonary surfactant显示文摘 | Sullivan L C Daniels C B Phillips I D | 1998 | Mol Evol1998，46，2： | 1 |
| 17 | Effects of ur- ban sewage on dissolved oxygen,dissolved inorganic and organ- ic carbon,and electrical conductivity of small streams along agradient of urbanization in the Piracicaba river basin显示文摘 | Daniel M H B Montebelo A A Bemardes M C | 2002 | Water Air and Soil Pollution2002，136，： | 1 |
| 18 | The concept of wage-push inflation : Development and policy 显示文摘 | Daniel J B Mitchell C L E | 2008 | Labor History2008，4，49： | 1 |
| 19 | Therapeuticuse of citrulline in cardiovascular disease显示文摘 | MARITZA J R DANIEl H P RUTH B C | 2006 | Cardiovascul Drug Rev2006，24，34： | 1 |
| 20 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
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