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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Acute fatty liver of pregnancy associated with severe acute pancreatitis:A case report显示文摘Acute fatty liver of pregnancy is a rare disease that affects women in the third trimester of pregnancy. Although infrequent, the disease can cause maternal mortality. The diagnosis is not always clear until the pregnancy is terminated, and significant complications, such as acute pancreatitis, can occur. Pancreatic involvement typically only occurs in severe cases after the development of hepatic and renal impairment. To date, little knowledge is available regarding how the disease causes pancreatitis. Treatment involves supportive measures and pregnancy interruption. In this report, we describe a case of a previously healthy 26-year-old woman at a gestational age of 27 wk and 6 d who was admitted with severe abdominal pain and vomiting. This case illustrates the clinical and laboratory overlap between acute fatty liver of pregnancy and pancreatitis, highlighting the difficulties in differentiating each disease. Furthermore, the hypothesis for this overlapping is presented, and the therapeutic options are discussed. | Cássio Vieira de Oliveira Alecsro Moreira Julio P Baima Leticia de C Franzoni Talles B Lima Fabio da S Yamashiro Kunie Yabuki Rabelo Coelho Ligia Y Sassaki Carlos Antonio Caramori Ferno G Romeiro Giovanni F Silva | 2014 | World Journal of Hepatology2014，6，7： | 3 |
| 3 | Physiological responses to salt stress in young umbu plants显示文摘 | Da Silva E C Nogueira R J M C de Arajo F P etal | 2008 | Environmental and Experimental Botany2008，63，3： | 1 |
| 4 | Nature of carbohydrates associated with water-stable aggregates of two cultivated soils 显示文摘 | PUGET P ANGERS DA CHENU C | 1999 | Soil Biology and Biochemistry1999，31，： | 1 |
| 5 | Soil physical quality of aBrazilian Oxisol under two tillage systems using the least limiting waterrange approach显示文摘 | TORMENA C A DA SILVA A P LIBARDI P L | 1999 | Soil&Tillage Research1999，52，： | 1 |
| 6 | New catalysts fordeep hydrotreatment of diesel fuel: Kinetics of 4,6-dimethyldibenzothiophenehydrodesulfurization over aluminasupportedmolybdenum carbide显示文摘 | Costa P Da Potvin C Manoli J M | 2002 | Journal of MolecularCatalysis A: Chemistry2002，184，12： | 1 |
| 7 | Characterization of Pore Systems in Seal Rocks Using Nitrogen Gas Adsorption Combined with Mercury Injection Capillary Pressure Techniques 显示文摘 | Schmitt M Fernandes C P da Cunha Neto J A B | 2013 | Marine and Petroleum Geology2013，39，1： | 1 |
| 8 | Nutri- ent availability and leaching in an archaeological anthrosol and a Ferralsol of the Central Amazon basin: Fertilizer, manure and charcoal amendments显示文摘 | LEHMANN J DA SILVA JR J P STEINER C | 2003 | Plant and Soil2003，249，2： | 1 |
| 9 | Immobilization of commercial laccase on spent grain显示文摘 | da Silva A M Tavare A P M Rocha C M R | 2012 | Process Biochem2012，479，7： | 1 |
| 10 | Analytical models of adhesively bonded joints-Part I:literature survey显示文摘 | da Silva L F M das Neves P J C Adams R D | 2009 | International Journal of Adhesion and Adhesives2009，29，3： | 1 |
| 11 | Diel Variation of Larval Fish Abundance in the Amazon and Rio Negro显示文摘 | ARAUJO-LIMA C A DA SILVA V V PETRY P | 2001 | Brazilian Journal of Biology2001，61，3： | 1 |
| 12 | Experimental assessment of perfobond and T- perfobond shear connectors' structural response 显示文摘 | Vianna J da C Costa-Neves L F da S Vellasco P C G | 2008 | Journal of Constructional Steel Research2008，65，2： | 1 |
| 13 | The impedance of stainless-steel electrodes显示文摘 | Geddes L A Da Costa C P Wise G | 1971 | Medical & Biological Engineering1971，9，5： | 1 |
| 14 | Structure of NiCrAlY coatings deposited on single-crystal alloy turbine blade material by laser cladding 显示文摘 | VILAR R SANTOS E C FERREIRA P N FRANCO N DA SILVA | 2009 | Acta Materialia2009，57，18： | 1 |
| 15 | Least limiting water range:A potential indicator of changes in near-surface soil physical quality afterthe conversion of Brazilian Savanna into pasture显示文摘 | LEO T P DA SILVA AP MACEDO M C M | 2006 | Soil&Tillage Re-search2006，88，： | 1 |
| 16 | 3D reconstitution of porous media from image processing data using a mulfiscale percolation system 显示文摘 | DAIAN J F FERNANDES C P PHILIPPI P C BELLINI DA CUNHA NETO J A | 2004 | Journal of Petroleum Science and Engineering2004，42，1： | 1 |
| 17 | A parametric study of forced convection in an enclosure with stationary heated cylinders显示文摘 | Guimar?es P M Da Silva C E S | 2010 | International Communications in Heat and Mass Transfer2010，37，5： | 1 |
| 18 | Structural behaviour of T-perfobond shear connectors in composite girders: An experimental approach显示文摘 | Vianna J da C Costa-Neves L F da S Vellasco P C G | 2008 | Engineering Structures2008，30，9： | 1 |
| 19 | Biodistribution of phosphodiester and phosphorothioate siRNA 显示文摘 | BRAASCH DA ZAIN P ANCA C | 2004 | Bioorg Med Chem Lett2004，14，12： | 1 |
| 20 | Detailed aH and 13C NMR structural assignment of three biologically active lignan lactones 显示文摘 | Vladimir C G H Rosangela da S Susimaire P | 2006 | Spectroehim Aeta PartA2006，63，： | 1 |
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