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| 1 | Molecular mechanisms of liver ischemia reperfusion injury:Insights from transgenic knockout models显示文摘Ischemia reperfusion injury is a major obstacle in liver resection and liver transplantation surgery.Understanding the mechanisms of liver ischemia reperfusion injury(IRI) and developing strategies to counteract this injury will therefore reduce acute complications in hepatic resection and transplantation,as well as expanding the potential pool of usable donor grafts.The initial liver injury is initiated by reactive oxygen species which cause direct cellular injury and also activate a cascade of molecular mediators leading to microvascular changes,increased apoptosis and acute inflammatory changes with increased hepatocyte necrosis.Some adaptive pathways are activated during reperfusion that reduce the reperfusion injury.IRI involves a complex interplay between neutrophils,natural killer T-cells cells,CD4+ T cell subtypes,cytokines,nitric oxide synthases,haem oxygenase-1,survival kinases such as the signal transducer and activator of transcription,Phosphatidylinositol 3-kinases/Akt and nuclear factor κβ pathways.Transgenic animals,particularly genetic knockout models,have become a powerful tool at elucidating mechanisms of liver ischaemia reperfusion injury and are complementary to pharmacological studies.Targeted disruption of the protein at the genetic level is more specific and maintained than pharmacological inhibitors or stimulants of the same protein.This article reviews the evidence from knockout models of liver IRI about the cellular and molecular mechanisms underlying liver IRI. | Gourab Datta Barry J Fuller Brian R Davidson | 2013 | World Journal of Gastroenterology2013，19，11： | 50 |
| 2 | Bt水稻对飞虱和叶蝉及其卵寄生蜂扩散规律的影响显示文摘研究了Bt水稻两个纯合品系TT9-3和TT9-4在田间对飞虱、叶蝉及其卵寄生蜂扩散规律的影响。结果表明:在Bt稻区与对照(IR72)区间相互扩散的飞虱有白背飞虱(Sogatellafurcifea)、褐飞虱(Nilaparvatalugens);叶蝉有黑尾叶蝉(Nephotetixcincticeps)、白翅叶蝉(Erythroneurasubrufa)和电光叶蝉(Deltpcephalusdorsalis);其中以白背飞虱和黑尾叶蝉为主。扩散数量叶蝉多于飞虱;扩散方向以Bt稻区向对照区扩散为主,其中TT9-3与IR72、TT9-4与IR72间白背飞虱与黑尾叶蝉的扩散量差异均达显著水平(P<0.05)。在Bt稻区与对照区间相互扩散的飞虱和叶蝉的卵寄生蜂有稻虱缨小蜂(Anagrusspp.)和叶蝉柄翅小蜂(Lynaenonlongicrus),数量上后者多于前者,扩散方向也以Bt稻区向对照区扩散为主。 | 陈茂 叶恭银 胡萃 Tu J Datta S K | 2003 | 浙江大学学报(农业与生命科学版)2003，29，1： | 30 |
| 3 | Extraordinary evanescent field confinement waveguide sensor for mid-infrared trace gas spectroscopy显示文摘Nanophotonic waveguides are at the core of a great variety of optical sensors.These structures confine light along defined paths on photonic chips and provide light-matter interaction via an evanescent field.However,waveguides still lag behind free-space optics for sensitivity-critical applications such as trace gas detection.Short optical pathlengths,low interaction strengths,and spurious etalon fringes in spectral transmission are among the main reasons why on-chip gas sensing is still in its infancy.In this work,we report on a mid-infrared integrated waveguide sensor that successfully addresses these drawbacks.This sensor operates with a 107%evanescent field confinement factor in air,which not only matches but also outperforms free-space beams in terms of the per-length optical interaction.Furthermore,negligible facet reflections result in a flat spectral background and record-low absorbance noise that can finally compete with free-space spectroscopy.The sensor performance was validated at 2.566μm,which showed a 7 ppm detection limit for acetylene with only a 2 cm long waveguide. | Marek Vlk Anurup Datta Sebastián Alberti Henock Demessie Yallew Vinita Mittal Ganapathy Senthil Murugan Jána Jagerská | 2021 | Light(Science & Applications)2021，10，2： | 9 |
| 4 | Downregulation of miR-122 in the rodent and human hepatocellular carcinomas显示文摘 | Kutay H Bai S Datta J | 2006 | J Cell Biochem2006，99，3： | 1 |
| 5 | Design and analysis of trailing-edge flaps and servotabs for primary control 显示文摘 | Falls J Datta A Chopra I | 2010 | Journal of AHS2010，55，3： | 1 |
| 6 | Evolution and soil entrapment of nitrogen gases formed by denitrification in flooded soil 显示文摘 | Samson M I Buresh R J De Datta S K | 1990 | Soil Science and Plant Nutrition1990，36，： | 1 |
| 7 | Image retrieval:ideas,influences,and trends of the new age显示文摘 | Datta R Joshi D Li J | 2008 | ACM ComputingSurveys2008，40，2： | 1 |
| 8 | Adaptive internal model control: Design and stability analysis显示文摘 | Datta A Ochoa J | 1996 | Automatica (S0005-1098)1996，32，2： | 1 |
| 9 | New Results on the Synthesis of PID Controllers显示文摘 | Silva G J Datta A Bhattacharyya S P | 2002 | IEEE Trans on Automatic Control2002，47，2： | 1 |
| 10 | The molecular basis of sun induced premature skin ageing and retinoid antagonism显示文摘 | Fisher G J Datta S C Talwar H S | 1996 | Nature1996，379，6563： | 1 |
| 11 | Selective coactivator interactions in gene activation by SREBP-1 a and-1 c显示文摘 | DATTA S ATHANIKAR J N | 2004 | Mol Cell Biol2004，24，18： | 1 |
| 12 | IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling pathway显示文摘 | Yadav A Kumar B Datta J | 2011 | Mol Cancer Res2011，9，12： | 1 |
| 13 | Effect of amniotic fluid on coagulation and platelet thnction in pregnancy: an evaluation using thromboelastography显示文摘 | Harnett M J Hepner D L Datta S | 2005 | Anaesthesia2005，60，11： | 1 |
| 14 | Arabidopsis vegetative storage protein is an anti-insect acid phosphatase显示文摘 | Liu Y Ahn J E Datta S | 2005 | Plant Physiol2005，139，： | 1 |
| 15 | Effect of saponin extractson oxygen uptake and haematology of an air-breathingclimbing perch,Anabas testudineus(Bloch)显示文摘 | Roy P K Datta Munshi J | 1989 | Fresh-water Biology1989，1，2： | 1 |
| 16 | Investigation of sequential mitomycin C and photodynamic therapy in a mitomycin-resistant bladder cancer cell-line model显示文摘 | French A J Datta S N Allman R | 2004 | BJU Int2004，93，1： | 1 |
| 17 | Field performance of transgenic elite commercial hybrid rice expressing Bacillus thuringensis endoprotein 显示文摘 | Tu J Zhang G Datta K | 2000 | Nature BioTechnology2000，18，： | 1 |
| 18 | Heat-induced andother chemical changes in commercial UHT milks 显示文摘 | Elliott A J Datta N Amenu B | 2005 | Journal of Dairy Research2005，72，4： | 1 |
| 19 | Ghrelin in the regulation of body weight and metabolism显示文摘 | Castaneda TR Tong J Datta R | 2010 | Front Neuroendocrinol2010，31，1： | 1 |
| 20 | Expression and function of a hybrid Bt toxin gene in transgenic rice conferring resistance to insect pests显示文摘 | Tu J Datta K Alam M F | 1998 | Plant Bioteehnol1998，15，： | 1 |
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