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| 1 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 2 | Factors influencing mercury accumulation in three species of forage fish from Caddo Lake, Texas, USA显示文摘Most studies that have examined mercury (Hg) contamination of fish have focused on game species feeding near the top of the food web, while studies that examine forage fish that feed near the base of the food web are rare. We conducted a survey of Hg contamination in three species of forage fish, brook silverside (Labidesthes sicculus), threadfin shad (Dorosoma petenense) and gizzard shad (Dorosoma cepedianum), from Caddo Lake, Texas, USA and found species-specific differences in Hg concentrations. We examined total length, age, trophic position (determined using δ15N), and growth rate of forage fish as factors that could have influenced within-and between-species differences in Hg concentration. Total length and age were the best predictors of within-species differences in Hg concentration. Between-species differences in Hg concentrations were most strongly influenced by trophic position. | Matthew M Chumchal Ray W Drenner David R Cross K David Hambright | 2010 | Journal of Environmental Sciences2010，22，8： | 3 |
| 3 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 3 |
| 4 | Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma显示文摘The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral(HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. Recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models toaddress the problems of liver cancer, especially HBVassociated HCC occurrences in Asia. | Amy P Chiu Barbara R Tschida Lilian H Lo Branden S Moriarity Dewi K Rowlands David A Largaespada Vincent W Keng | 2015 | World Journal of Gastroenterology2015，21，42： | 2 |
| 5 | Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage. | Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 6 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 7 | Ecological Linkages Between Aboveground and Belowground Biota显示文摘 | DAVID A W RICHARD D B JOHN N K | 2004 | Science2004，304，： | 1 |
| 8 | Determination of global kinetics of coal volatiles com- bustion 显示文摘 | Shaw David W Zhu Xuedong Misra Mahendra K | 1991 | Symposium (International) on Combustion1991，28，1： | 1 |
| 9 | New frontiers in food enzymology: recombinant lipoxygenases显示文摘 | Casey R West S I Hardy D David S Robinson Zecai W u Richard K Hughes | 1999 | Trends in Food Science & Technology1999，10，： | 1 |
| 10 | Negative pH and extremely acidic mine waters from ironmountain, Califomia显示文摘 | DARRELL K N CHARLES N A CAROL J P DAVID W B | 2000 | Environmental Science and Technology2000，34，： | 1 |
| 11 | Ramsdellite-MnO2 for lithium batteries: The ramsdellite to spinel transformation显示文摘 | THACKERAY M M ROSSOUW M H GUMMOW R J LILES D C PEARCE K KOCK A D DAVID W I F HULLS S | 1993 | Electrochim Acta1993，38，9： | 1 |
| 12 | Combined promotional effect of CO2 and Ni on Co/Mn/Br^-catalyst in the liquid-phase oxidation of p-xylene显示文摘 | David R B Jun K W Jin S | 2002 | Catal Lett2002，81，： | 1 |
| 13 | Treating non-compatible problem from matter element analysis to extenics 显示文摘 | David K W Ng Cai Wen | 1997 | ACM Sigice Bulletin1997，22，3： | 1 |
| 14 | Visible light photoredox catalysis with transition metal complexes:applications in organic synthesis显示文摘 | Christopher K P Danica A R David W C M | 2013 | Chem Rev2013，113，： | 1 |
| 15 | Effects of mutations in Arabidopsis FtsZ1 on plastid division, FtsZ ring formation and position- ing, and FtsZ filament morphology in vivo 显示文摘 | David W Y Deena K K | 2007 | Plant and Cell Physiology2007，48，6： | 1 |
| 16 | Relationships between microbial water quality and environmental conditions in coastal recreational waters: The fylde coast, UK显示文摘 | Crowther J David K Mark D W | 2001 | Water Research2001，35，17： | 1 |
| 17 | Medication er- rors and adverse drug events in pediatric inpatients显示文摘 | Rainu K David W Christopher L | 2001 | JA- MA2001，285，16： | 1 |
| 18 | Real-time landslide warning during heavy rainfall显示文摘 | David K K Raymond C W Robert K M | 1987 | Science1987，238，： | 1 |
| 19 | Regional carbon dynamics in monsoon Asia and its implications for the global carbon cycle显示文摘 | Tian H Q Melillo J M David W K | 2003 | Global and Planetary Change2003，37，34： | 1 |
| 20 | Movements,survivals and reproductions of Sage Grousetranslocated in to central Idaho显示文摘 | DAVID D M CONNELLY J W REESE K P | 1993 | Wildl Manage1993，57，1： | 1 |
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