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| 1 | The polymorphism of heat shock protein 70 genes in Chinese Han population in Fujian province显示文摘To understand the polymorphism of the heat shock protein 70 (HSP70) genes in Chinese Han population and to explore the co-relations between HSP70 polymorphism and disease, three polymorphic loci of HSP70 genes in 127 healthy Chinese Han population in Fujian province were analyzed by PCR and restriction enzyme analysis, and the genotypes and allele frequencies of HSP70 in different populations from various area were compared. It was found that the proportions of HSP70-1 genotypes GG, GC and CC among Chinese Han population in Fujian province were 55.1%, 40.2% and 4.7% respectively, while those of HSP70-2 genotypes AA, AG and GG were 44.1%, 48.8% and 6.9% respectively, and those of HSP70-hom genotypes TT, TC and CC were 59.8%, 37.0% and 3.2% respectively. The allele frequencies of G and C in HSP70-1 were 75.2% and 24.8%; those of A and G in HSP70-2 were 68.5% and 31.5% and those of T and C in HSP70-hom were 78.3% and 21.7% respectively. The distribution of the HSP70-1 polymorphisms in Chinese Han population was almost the same as those in Japanese and Mexican populations, but it was rather different from those of American and Spanish populations with a significant differences. Meanwhile, the frequency of GG homozygote in HSP70-1 was significantly higher than those in American and Spanish populations. No significant difference was found in the distribution of HSP70-2 polymorphism between Chinese and Japanese populations, in which the differences among American, Mexican and Spanish populations were quite obvious. The frequency of AA homozygote in HSP70-2 was significantly higher than those in Mexican, American and Spanish populations, while, the distribution of HSP 70-hom genotype and allele frequency in Chinese Han population was almost just the same as those in Japanese and Mexican populations. Furthermore, it was also found that the genotype distribution and allele frequencies of the HSP70 genes in Han population of Fujian province were almost the same as those in Han population in Taiwan, but they were different in certain loci from those of Han population in Wuhan area. It is evident that the distribution of HSP70 gene polymorphisms among Chinese Han population are different from other regions in the world. | JING AN LIN WEN QING LI DE FE YE YUE YONG ZHU | 2005 | Journal of Microbiology and Immunology2005，3，3： | 2 |
| 2 | NOD/SCID mice engineered to express human IL-3, GM-CSF and steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration显示文摘 | Nicolini FE Cashman JD Hogge DE | 2004 | Leukemia2004，18，： | 1 |
| 3 | Coagulopathy,hypothermia and acidosis in trauma patients the rationale for damage control surgery显示文摘 | De Waele JJ Vermassen FE | 2002 | Acta Chir Belg2002，102，5： | 1 |
| 4 | Brain imaging in patients with diabetes: A systematic review显示文摘 | van Harten B de Leeuw FE Weinstein HC | 2006 | Diabetes Care2006，29，11： | 1 |
| 5 | Hypertension and cerebral white matter lesion in a prospective cohort study显示文摘 | De Leeuw FE de Groot JC Oudkerk M | 2002 | Brain2002，125，4： | 1 |
| 6 | Brain imaging in patients with diabetes: a systematic review 显示文摘 | van Harten B de Leeuw FE Weinstein HC | 2006 | Diabetes Care2006，29，11： | 1 |
| 7 | Stage Ⅰ Multiple Myeloma:Value of MR Imaging of the Bone Marrow in the Determination of Prognosis显示文摘 | Van de Berg BC Lecouvet FE Michaux L | 1996 | Radiology1996，201，1： | 1 |
| 8 | Brain imaging in patients with diabetes:systematic review显示文摘 | Van Harten B de Leeuw FE Weinstein HC | 2006 | Diabetes Care2006，29，11： | 1 |
| 9 | Prevalence of cerebral white matter lesions in elderly people:a population based magnetic resonance imaging study, The Rotterdam Scan Study显示文摘 | de Leeuw FE de Groot JC Achten E | 2001 | J Neurol Neurosurg Psychiatry2001，70，1： | 1 |
| 10 | Early irreversible osteonecrosis versus transient lesions of the femoral condyles:prognostic value of subchondral bone and marrow changes on MR imaging显示文摘 | Lecouvet FE van de Berg BC Maldague BE | 1998 | AJR Am J Roentgenol1998，170，1： | 1 |
| 11 | Cererbral haemodynamics in the elderly:The Rotterdam Study显示文摘 | Bakker SLM de Leeuw FE den Heijer T | 2004 | Neuroepdemiology2004，23，： | 1 |
| 12 | Increased expression of both insulin receptor substrates 1 and 2 confers increased sensitivity to IGF-1 stimulated cell migration显示文摘 | de Blaquière GE May FE Westley BR | 2009 | Endocr Relat Cancer2009，16，2： | 1 |
| 13 | Familial primary biliary cirrhosis reassessed:a geographically-based population study显示文摘 | Jones DE Watt FE Metcalf JV | 1999 | J Hepatol1999，30，3： | 1 |
| 14 | Coagulopathy,hypothermia and acidosis intrauma patients:the rationale for damage control surgery显示文摘 | De Waele JJ Vermassen FE | 2002 | Acta Chir Belg2002，102，： | 1 |
| 15 | Hypen ricemia in primary and renal hypetention显示文摘 | Cannon PJ Stason WB De martilli FE | 2006 | N Engl J Med2006，275，6： | 1 |
| 16 | Hypertension and cerebral white matter lesions in a prospective cohort study显示文摘 | de Leeuw FE de Groot JC Oudkerk M | | 0，，： | 1 |
| 17 | HSP- 72 synthesis is promoted by increase in i or activation of G protein but not pHi or camp显示文摘 | Carr FE Burns MR Mcclain DE | 1994 | Amer J Physiol1994，267，： | 1 |
| 18 | Hipp-ocampal volume and subcortical white matter lesions in latelife depression:comparison of early and late onset depres-sion显示文摘 | Janssen J Hulshoff Pol HE de Leeuw FE | 2007 | J Neurol Neurosurg Psychiatry2007，78，6： | 1 |
| 19 | Alzheimer's disease-one clinical syndrome,two radiological expressions:a study on blood pressure显示文摘 | Barkhof F Scheltens P | 2004 | J Neurol Neurosurg Psychiatry2004，75，： | 1 |
| 20 | Time course and risk factors of post-stroke fatigue: a prospective cohort study 显示文摘 | Snaphaana L van der Weft S de Leeuwa FE | 2011 | Eur J Neurol2011，18，4： | 1 |
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