|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Application of a biochemical and clinical model to predict individual survival in patients with end-stage liver disease显示文摘AIM:To investigate the capability of a biochemical and clinical model,BioCliM,in predicting the survival of cirrhotic patients.METHODS:We prospectively evaluated the survival of 172 cirrhotic patients.The model was constructed using clinical(ascites,encephalopathy and variceal bleeding) and biochemical(serum creatinine and serum total bilirubin) variables that were selected from a Cox proportional hazards model.It was applied to estimate 12-,52-and 104-wk survival.The model's calibration using the Hosmer-Lemeshow statistic was computed at 104 wk in a validation dataset.Finally,the model's validity was tested among an independent set of 85 patients who were stratified into 2 risk groups(low risk≤8 and high risk>8).RESULTS:In the validation cohort,all measures of fi t,discrimination and calibration were improved when the biochemical and clinical model was used.The proposed model had better predictive values(c-statistic:0.90,0.91,0.91) than the Model for End-stage Liver Disease(MELD) and Child-Pugh(CP) scores for 12-,52-and 104-wk mortality,respectively.In addition,the Hosmer-Lemeshow(H-L) statistic revealed that the biochemical and clinical model(H-L,4.69) is better calibrated than MELD(H-L,17.06) and CP(H-L,14.23).There were no significant differences between the observed and expected survival curves in the stratified risk groups(low risk,P=0.61;high risk,P=0.77).CONCLUSION:Our data suggest that the proposed model is able to accurately predict survival in cirrhotic patients. | Eduardo Vilar Gomez Luis Calzadilla Bertot Bienvenido Gra Oramas Enrique Arus Soler Raimundo Llanio Navarro Javier Diaz Elias Oscar Villa Jiménez Maria del Rosario Abreu Vazquez | 2009 | World Journal of Gastroenterology2009，15，22： | 6 |
| 2 | Antioxidant and immunomodulatory effects of Viusid in patients with chronic hepatitis C显示文摘AIM:To investigate the efficacy of Viusid,a nutritional supplement,as an antioxidant and an immunomodulator in patients with chronic hepatitis C.METHODS:Sixty patients with chronic hepatitis C who were non-responders to standard antiviral treatment were randomly assigned to receive Viusid(3 sachets daily,n=30) or placebo(n=30) for 24 wk.The primary outcome was the change in serum malondialdehyde and 4-hydroxyalkenals(lipid peroxidation products).Secondary outcomes were changes in serum tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ) and interleukin-10(IL-10).RESULTS:Statistically significant reductions in serum 4-hydroxyalkenals and malondialdehyde levels were observed in both groups in comparison with pretreatment values,but the patients who received Viusid showed a more marked reduction as compared with the control group(P=0.001).TNF-α levels significantly increased from 6.9 to 16.2 pg/mL(P< 0.01) in the patients who received placebo in comparison with almost unchanged levels,from 6.6 to 7.1 pg/mL(P=0.26),in the patients treated with Viusid(P=0.001).In addition,IL-10 levels were markedly increased in the patients treated with Viusid(from 2.6 to 8.3 pg/mL,P=0.04) in contrast to the patients assigned to placebo(from 2.8 to 4.1 pg/mL,P=0.09)(P=0.01).Likewise,the administration of Viusid markedly increased mean IFN-γ levels from 1.92 to 2.89 pg/mL(P< 0.001) in comparison with a reduction in mean levels from 1.80 to 1.68 pg/mL(P=0.70) in the placebo group(P< 0.0001).Viusid administration was well tolerated.CONCLUSION:Our results indicate that treatment with Viusid leads to a notable improvement of oxidative stress and immunological parameters in patients with chronic hepatitis C. | Eduardo Vilar Gomez Yadina Martinez Perez Hector Vega Sanchez Gretel Riveron Forment Enrique Arus Soler Luis Calzadilla Bertot Ali Yasells Garcia Maria del Rosario Abreu Vazquez Licet Gonzalez Fabian | 2010 | World Journal of Gastroenterology2010，16，21： | 2 |
| 3 | Giardia duodencdis: adhesion-deficient clones have reduced a- bility to establish infection in Mongolian gerbils 显示文摘 | Hemandez-Sanchez J Linan RF Del Rosario Salinas-Tobon M | 2008 | Exp Para- sitol2008，119，3： | 1 |
| 4 | BMP- induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK 显示文摘 | Beck SE Jung BH Del Rosario E | 2007 | Cell Signal2007，19，7： | 1 |
| 5 | Muhimodal management of lateral epi- condylatgia in rock climbers:a prospective case series显示文摘 | GONZALEZ-IGLESIAS J CLELAND J A DEL ROSARIO GU- TIERREZ-VEGA M | 2011 | J Manip- ulative Physiol Ther2011，34，9： | 1 |
| 6 | RAGE regulates the metabolic and inflammatory response to high-fat feeding in mice 显示文摘 | Song F Hurtado del Pozo C Rosario R | 2014 | Diabetes2014，63，6： | 1 |
| 7 | Out-of- pocket medical expenses for inpatient care among bene- ficiaries of the National Health Insurance Program in the Philippines 显示文摘 | Tobe M Stickley A del Rosario RB Jr | 2013 | Health Policy Plan2013，28，5： | 1 |
| 8 | The role of lipid peroxidation in storage disorders of fresh fruits and vegetables显示文摘 | Shewfelt RL Del Rosario BA | 2000 | HortScience2000，35，4： | 1 |
| 9 | Repletion of the plasma pool of nutrient transport proteins occurs at different rates during the nutritional rehabilitation of severely malnourished children显示文摘 | Morless JF Forrester T Del Rosario M | 1998 | Nutr1998，128，2： | 1 |
| 10 | Conversion of dextrinized cassava starch into ethanol using cultures of Aspergillus awamori and Saccharomyces cerevisiae显示文摘 | Ernesto J del Rosario Roberto L Wong | 1984 | Enzyme Microb Technol1984，6，： | 1 |
| 11 | First detection of metallo-β- lactamase VIM-2 in Pseudomonas aeruginosa isolates from colombia显示文摘 | Maria Virginia Villegas Karen Lolans Maria del Rosario Olivera | 2006 | Antimicrobial Agents and Chemotherapy2006，50，1： | 1 |
| 12 | Primary and Reversible Pisa Syndrome in Juvenile Normal Pressure Hydrocephalus 显示文摘 | Leon-Sarmiento FE Pradilla G Del Rosario Zambrano M | 2013 | Aeta Neuropsyehiatr2013，25，1： | 1 |
| 13 | Choleretic effect and intestinal propulsion of ‘mate' (Ilex paraguariensis) and its substitutes or adulterants显示文摘 | Rosana Filip María del Rosario Alonso | 2001 | Ethnopharmacology2001，，75： | 1 |
| 14 | Venous angioma with associate cerebellar haemorrrhage 显示文摘 | Sanche Z Medina Y Perez Del Rosario PA | 2013 | Neuro- cirugia2013，24，2： | 1 |
| 15 | Conversion of dextrinized cassava starch into ethanol using cultures of Aspergillus awamori and Saccharomyces cerevisiae 显示文摘 | Ernesto J del Rosario Roberto L Wong | 1984 | Enzyme Microb Technol1984，6，： | 1 |
| 16 | Speciation of metallothionein-like proteins of the mussel Mytilus edulis by orthogonaI separate on mechanisms with induetively coupled plasma-mass spectrometry detection: effect of sele nium Administration 显示文摘 | Ferrarello C N del Rosario Fernandez de la Campa M Carrasco J F | 2002 | Spectrochimica Acta Part B: Atomic Spectroscopy2002，57，3： | 1 |
| 17 | The role of lipid peroxidation in stor-age disorders of fresh fruits and vegetables显示文摘 | SHEWFELT R DEL ROSARIO B | 2000 | Hort Science2000，35，4： | 1 |
| 18 | Synthesis and prelim- inary evaluation of -(-)-phenylephrine as a functional heart neuronal PET agent 显示文摘 | Del Rosario RB Jung YW Caraher J et at | 1996 | Nucl Med Biol1996，23，5： | 1 |
| 19 | Clinical evaluation of carbon-1 l-phenylephrine: MAO-sensitive marker of cardiac sym- pathetic neurons显示文摘 | Raffel DM Corbett JR del Rosario RB et M | 1996 | J Nucl Med1996，37，12： | 1 |
| 20 | Statins decrease the risk of acute pancreatitis after endoscopic ultrasound fine-needle aspiration of pancreatic cysts显示文摘Background: Basic and clinical studies suggest that statins may prevent and even ameliorate acute pan- creatitis. The present study was to evaluate whether statin decreases the risk of acute pancreatitis in patients undergoing endoscopic ultrasound-guided ne-needle aspiration of pancreatic cysts. Methods: Out of 456 patients with pancreatic cysts referred to our center between 2006 and 2018, 365 were nally included in analyses: 86 were treated with statins and 279 were not at the time of endo- scopic ultrasound ne-needle aspiration. We compared the acute pancreatitis incidence between the two groups, and we also compared other complications such as bleeding and infections. Results: Median age was 64 years [interquartile range (IQR) 62 69] and median cyst size was 24mm (IQR, 21 29). The most frequent histology was intraductal papillary mucinous neoplasm (45.3% and 42.3% in the two groups, respectively;P =0.98). All 13 patients experiencing post-endoscopic ultrasound acute pancreatitis were from the control group (4.7%), of which 3 were classi ed as severe pancreatitis. None of statin users developed post-procedural acute pancreatitis (odds ratio: 0.15;95% con dence interval: 0.03 0.98;P=0.03). No difference was registered with regard to severe pancreatitis and other complications. Conclusions: Statins exert a bene cial role in preventing acute pancreatitis in patients with pancreatic cysts undergoing endoscopic ultrasound-guided ne-needle aspiration. If con rmed in prospective trials, our ndings may pave the way to an extensive use of statins as prophylactic agents in pancreatic inter- ventional endoscopy. | Antonio Facciorusso Vincenzo Rosario Buccino Valentina Del Prete Matteo Antonino Antonella Contaldo Nicola Muscatiello | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员