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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 3 | Correlation between water diffusion and adhesion loss: Study of an epoxy primer on steel显示文摘 | Elise Legghe Emmanuel Aragon Léna?k Bélec André Margaillan Denis Melot | 2009 | Progress in Organic Coatings2009，，3： | 2 |
| 4 | Obesity and cardiometabolic disease risk factors among US adolescents with disabilities显示文摘AIM: To generate prevalence estimates of weight status and cardiometabolic disease risk factors among adolescents with and without disabilities.METHODS: Analysis of the 1999-2010 National Health and Nutrition Examination Survey data was conducted among 12-18 years old with(n = 256) and without disabilities(n = 5020). Mean values of waist circumference, fasting glucose, high-density-lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressure and metabolic syndrome(Met S, ≥ 3 risk factors present) were examined by the following standardized body mass index(BMI) categories for those with and without disabilities; overweight(BMI ≥ 85th- < 95 th percentile for age and sex), obesity(BMI ≥ 95 th percentile) and severe obesity(BMI ≥35 kg/m2). Linear regression models were fit with each cardiometabolic disease risk factor independently as continuous outcomes to show relationships with disability status. RESULTS: Adolescents with disabilities were significantlymore likely to be overweight(49.3%), obese(27.6%) and severely obese(12%) vs their peers without disabilities(33.1%, 17.5% and 3.6%, respectively, P ≤ 0.01 for all). A higher proportion of overweight, obese and severely obese children with disabilities had abnormal SBP, fasting lipids and glucose as well as Met S(18.9% of overweight, 32.3% of obese, 55% of severely obese) vs their peers without disabilities(9.7%, 16.8%, 36.3%, respectively). US adolescents with disabilities are over three times as likely to have Met S(OR = 3.45, 95%CI: 1.08-10.99, P = 0.03) vs their peers with no disabilities.CONCLUSION: Results show that adolescents with disabilities are disproportionately affected by obesity and poor cardiometabolic health vs their peers with no disabilities. Health care professionals should monitor the cardiometabolic health of adolescents with disabilities. | Sarah E Messiah Denise C Vidot Gabriel Somarriba Kanathy Haney Semra Aytur Ruby A Natale Jeffrey P Brosco Kristopher L Arheart | 2015 | World Journal of Diabetes2015，6，1： | 2 |
| 5 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007，，10： | 2 |
| 6 | Tumor Marker Evolution: Comparison with Imaging for Assessment of Response to Chemotherapy in Patients with Colorectal Liver Metastases显示文摘 | Robbert J. Haas Dennis A. Wicherts Eduardo Flores Michel Ducreux Francis Lévi Bernard Paule Daniel Azoulay Denis Castaing Antoinette Lemoine René Adam | 2010 | Annals of Surgical Oncology2010，，4： | 2 |
| 7 | Management of computed tomography scan detected hemothorax in blunt chest trauma:What computed tomography scan measurements say?显示文摘AIM To investigate the hemothorax size for which tube thoracostomy is necessary.METHODS Over a 5-year period, we included all patients who were admitted with blunt chest trauma to our level 1 trauma center. Focus was placed on identifying the hemothorax size requiring tube thoracostomy.RESULTS A total number of 274 hemothoraces were studied. All patients with hemothoraces measuring above 3 cm received a chest tube. The 50% predicted probability of tube thoracostomy was 2 cm. Pneumothorax was associated with odds of receiving tube thoracostomy for hemothoraces below 2 cm(Odds Ratio:4.967, 95%CI: 2.225-11.097, P < 0.0001).CONCLUSION All patients with a hemothorax size greater than 3% underwent tube thoracostomy. Prospective studies are warranted to elucidate the clinical outcome of patients with smaller hemothoraces. | Mahdi Malekpour Kenneth Widom James Dove Joseph Blansfield Mohsen Shabahang Denise Torres Jeffrey L Wild | 2018 | World Journal of Radiology2018，10，12： | 2 |
| 8 | Diallielic single-stranded conformational polymorphism detected in the bovine prolactin gene显示文摘 | Zhang H M Denise S K Ax R L | 1994 | J Anim Sci1994，72，1： | 1 |
| 9 | Wood-polymer composite: Physi- cal and mechanical properties of some wood species impregnated with styrene and methyl methacrylate 显示文摘 | Denise O S Francisco A R L | 2004 | Materials Research2004，7，4： | 1 |
| 10 | Bio-transformation of betulinic and betulonic acids by fungi 显示文摘 | Denise Z Bastos L Pimentel I C | 2007 | phytochemistry2007，68，： | 1 |
| 11 | Scrutinizing the relationship between shyness and social phobia显示文摘 | Denise A Chavira Murray B Stein Vanessa L Malcarne | 2002 | Journal of Anxiety Disorders2002，，6： | 1 |
| 12 | Comparative bioleaching and mineralogy of eomposited sulfide ores contai- ning enargite, covellite and ehaleoeite by mesophilic and thermophilic microorganisms 显示文摘 | JAEHEON L SEVKET A DENISE L D | 2011 | Hydrometallurgy2011，105，34： | 1 |
| 13 | Evaluating inter-continental transport of fine aerosols:method-ology, global aerosol distribution and optical depth显示文摘 | Junfeng Liu Denise L Mauzerall | 2009 | Atmospheric Environment2009，43，28： | 1 |
| 14 | Equivocal roles of tissue-type plasminogen activator in stroke-induced injury显示文摘 | Karim Benchenane José P. López-Atalaya Mónica Fernández-Monreal Omar Touzani Denis Vivien | 2004 | Trends in Neurosciences2004，，3： | 1 |
| 15 | Changes in endogenous abscisic acid levels during dormancy release and maintenance of mature seeds: studies with the Cape Verde Islands ecotype, the dormant model of Arabidopsis thaliana显示文摘 | Sonia Ali-Rachedi Denise Bouinot Marie-Hélène Wagner Magda Bonnet Bruno Sotta Philippe Grappin Marc Jullien | 2004 | Planta2004，，3： | 1 |
| 16 | High- risk HPV testing in women with borderline and mild dys- karyosis:long-term follow-up data and clinical relevance 显示文摘 | Denise Zielinski G Snijders PJ Rozendaal L | 2001 | Pathol2001，195，3： | 1 |
| 17 | Corrosion Behaviour of Iron and AISI 304 Stainless Steel in Tungstate Aque-ous Solutions Containing Chloride显示文摘 | Denise S Azambuja Emilse M A Martini Iduvirges L Müller | 2003 | Journal of Brazilian Chemical Society2003，14，4： | 1 |
| 18 | Antimicrobial resistance profile of Actinobacillus pleuropneu moniae and Actinobacillus porcitonsillarum显示文摘 | Denise M Alexandra R Sandra L etal | 2007 | Veterinary Microbiology2007，122，： | 1 |
| 19 | Impacts of21st century climate change on global air pollution-related premature mortality显示文摘 | Fang Yuanyuan Mauzerall Denise L Liu Junfeng | 2013 | Climatic Change2013，121，2： | 1 |
| 20 | Sympathetic modulation of immunity:relevance to disease显示文摘 | Denise L Bellinger Brooke A Millar Sam Perez | 2008 | Cell Immunol2008，252，12： | 1 |
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