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| 1 | sTREM-1 is a specific biomarker of TREM-1 pathway activation显示文摘TREM-1(triggering receptor expressed on myeloid cells-1)is a transmembrane receptor expressed by innate immune cells,including endothelial cells and platelets.TREM-1 is a crucial mediator of septic shock that acts by synergizing with Toll-like receptors(TLRs)to amplify the inflammatory responses to pathogens,thus promoting sepsis-induced immune dysregulation and organ dysfunction[1,2,3]. | Lucie Jolly Kévin Carrasco Margarita Salcedo-Magguilli Jean-Jacques Garaud Simon Lambden Tom van der Poll Alexandre Mebazaa Pierre-François Laterre Sebastien Gibot Amir Boufenzer Marc Derive | 2021 | Cellular & Molecular Immunology2021，18，8： | 8 |
| 2 | Molecular mechanism and functional consequences of lansoprazole-mediated heme oxygenase-1 induction显示文摘AIM:To investigate the molecular mechanism and functional consequences of heme oxygenase-1(HO-1) activation by lansoprazole in endothelial cells and macrophages. METHODS:Expression of HO-1 mRNA was analyzed by Northern blotting.Western blotting was used to determine the HO-1 and ferritin protein levels. NADPH-dependent reactive oxygen species(ROS) formation was measured with lucigenin-enhanced chemiluminescence.HO-1 promoter activity in mouse fibroblasts,stably transfected with a 15-kb HO-1 gene that drives expression of the reporter gene luciferase, was assessed using in vivo bioluminescence imaging. RESULTS:Lansoprazole increased HO-1 mRNA levels in endothelial cells and HO-1 protein levelsin macrophages.In addition,lansoprazole-induced ferritin protein levels in both cell systems.Moreover, induction of the antioxidant proteins HO-1 and ferritin by lansoprazole was followed by a decrease in NADPH- mediated ROS formation.The radical scavenging properties of lansoprazole were diminished in the presence of the HO inhibitor,chromium mesoporphyrin IX.Induction of HO-1 gene expression by lansoprazole was not related to oxidative stress or to the activation of the mitogen-activated protein kinase pathway. However,the phosphatidylinositol 3-kinase inhibitor LY294002 showed a concentration-dependent inhibition of HO-1 mRNA and promoter activity. CONCLUSION:Activation of HO-1 and ferritin may account for the gastric protection of lansoprazole and is dependent on a pathway blocked by LY294002. | Stephanie Schulz-Geske Kati Erdmann Ronald J Wong David K Stevenson Henning Schrder Nina Grosser | 2009 | World Journal of Gastroenterology2009，15，35： | 7 |
| 3 | Performance of the Montreal classification for inflammatory bowel diseases显示文摘AIM:To validate the Montreal classification system for Crohn's disease(CD) and ulcerative colitis(UC) within the Netherlands.METHODS:A selection of 20 de-identified medical records with an appropriate representation of the inflammatory bowel disease(IBD) sub phenotypes were scored by 30 observers with different professions(gastroenterologist specialist in IBD,gastroenterologist in training and IBD-nurses) and experience level with IBD patient care.Patients were classified according to the Montreal classification.In addition,participants were asked to score extra-intestinal manifestations(EIM) and disease severity in CD based on their clinical judgment.The inter-observer agreement was calculated by percentages of correct answers(answers identical to the 'expert evaluation') and Fleiss-kappa(k).Kappa cutoffs:< 0.4-poor; 0.41-0.6-moderate; 0.61-0.8-good; > 0.8 excellent.RESULTS:The inter-observer agreement was excellent for diagnosis(k = 0.96),perianal disease(k = 0.92) and disease location in CD(k = 0.82) and good for age of onset(k = 0.67),upper gastrointestinal disease(k = 0.62),disease behaviour in CD(k = 0.79) and disease extent in UC(k = 0.65).Disease severity in UC was scored poor(k = 0.23).The additional items resulted in a good inter-observer agreement for EIM(k = 0.68) and a moderate agreement for disease severity in CD(k = 0.44).Percentages of correct answers over all Montreal items give a good reflection of the inter-observer agreement(> 80%),except for disease severity(48%-74%).IBD-nurses were significantly worse in scoring upper gastrointestinal disease in CD compared to gastroenterologists(P = 0.008) and gastroenterologists in training(P = 0.040).Observers with less than 10 years of experience were significantly better at scoring UC severity than observers with 10-20 years(P = 0.003) and more than 20 years(P = 0.003) of experience with IBD patient care.Observers with 10-20 years of experience with IBD patient care were significantly better at scoring upper gastrointestinal disease in CD than observers with less than 10 years(P = 0.007) and more than 20 years(P = 0.007) of experience with IBD patient care.CONCLUSION:We found a good to excellent interobserver agreement for all Montreal items except for disease severity in UC(poor). | Lieke M Spekhorst Marijn C Visschedijk Rudi Alberts Eleonora A Festen Egbert-Jan van der Wouden Gerard Dijkstra Rinse K Weersma | 2014 | World Journal of Gastroenterology2014，20，41： | 4 |
| 4 | 澳大利亚初产妇产后的膳食摄入和身体活动习惯与临床建议的关系显示文摘孕期和产后获得理想的膳食和身体活动行为对健康益处良多。了解预测这些行为的因素是一项重要的公共卫生考虑,然而有关产后妇女的饮食和身体活动行为与临床建议的关系所知甚少。澳大利亚迪肯大学开展了一项研究,旨在比较孕期和产后临床提供的膳食频率和身体活动建议,并评估该建议是否与产后膳食和身体活动行为相关。选取参加墨尔本婴儿喂养行为和营养试验项目(InFANT Extend)中完成了澳大利亚癌症委员会食物频率问卷的448个初产妇作为研究对象,产后3~4个月时评估其日常的水果和蔬菜的摄入量(份/天)。 | van der Pligt P Olander EK Ball K 段一凡 杨振宇 | 2016 | 中华预防医学杂志2016，50，12： | 3 |
| 5 | Itraconazole oral solution and intravenous formulations:a review of pharmacokinetics and pharmacodynamics显示文摘 | Willems L van der Geest R de Beule K | | 0，，： | 2 |
| 6 | Proportionate incresease of fibrinogen and albumin synthesis in nephritic patients:Measurements with stable isotopes显示文摘 | De Sain-van der Velden MGM Kaysen GA De Meek K et la | 1998 | Kidney Int1998，53，1： | 2 |
| 7 | Diffusion weighted magnetic resonance imaging in acute 显示文摘 | Van Everdingen K J Van der ground T Kappelle LJ | 2007 | Stroke2007，29，： | 1 |
| 8 | Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf -independent pathways显示文摘 | Shields J M Rogers Graham K Der C J | 2002 | J Biol Chem2002，277，12： | 1 |
| 9 | On the composition range of amorphous binary transition metal alloys 显示文摘 | VAN DER KOLK G J MIEDEMA A R NIESSEN A K | 1988 | J Less-Common Met1988，145，： | 1 |
| 10 | The friction and wear of Ni-P-PTFE composite deposite and water lubrication 显示文摘 | Ming Der Ger Hou K H WANG L M | 2002 | Materials Chemistry and Physics2002，77，3： | 1 |
| 11 | The Ras superfamily at a glance显示文摘 | Wennerberg K Rossman KL Der CJ | 2005 | J Cell Sci2005，118，5： | 1 |
| 12 | Significant changes in the bacterioplankton community structure of a maritime Antarctic fieshwater lake following nutrient enrichment显示文摘 | PEARCE D A van der GAST C J WOODWARD K | 2005 | Microbiology2005，151，10： | 1 |
| 13 | Catalytic growth of macroscopic carbon nanofiber bodies with high bulk density and high mechanical strength显示文摘 | Lee M K van der Dillen A J van Geus J W Jong K P de Bitter J H | 2006 | Carbon2006，44，： | 1 |
| 14 | Nanoscale engineering of biomimetic surfaces; Cues from the extracellular matrix显示文摘 | Von der Mark K Park J Bauer S | 2010 | Cell Tissue Res2010，339，1： | 1 |
| 15 | Mechanisms of disease: erythropoietin resistance in patients with both heart and kidney failure显示文摘 | van der Putten K Braam B Jie KE | 2008 | Nat Clin Pract Nephrol2008，4，1： | 1 |
| 16 | Graph coloring with adaptive evolutionary algorithms显示文摘 | EIBEN A E HAUW J K van der HEMERT J I van | 1998 | Journal of Heuristics1998，4，1： | 1 |
| 17 | Molecular analysis of the anthocyanin2 gene of petunia and its role in the evolution of flower color显示文摘 | QUATTROCCHIO F WING J F VAN DER WOUDE K | 1999 | Plant Cell1999，11，： | 1 |
| 18 | Central role of double-stranded RNA-activated protein kinase in microbial induction of nitric oxide synthase显示文摘 | Uetani K Der SD Zamanian-Daryoush M et a1 | 2000 | J Immunol2000，165，2： | 1 |
| 19 | Energy ex- penditure and balance following pediatric intensive care unit admis- sion: a longitudinal study of critically ill children 显示文摘 | Oosterveld M J Van Der Kuip M De Meer K | 2006 | Pediatr Crit Care Med2006，7，2： | 1 |
| 20 | Exposure to bleached kraft pulp milleflluent disrupts the pituitary-gonadal axis of white sucker at multiple sites 显示文摘 | Van Der Kraak G J Mun kittrick K R McMaster M E | 1992 | Toxicol Appl Pharmacol1992，，115： | 1 |
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