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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | Combination of repeated single-session percutaneous ethanol injection and transarterial chemoembolisation compared to repeated single-session percutaneous ethanol injection in patients with non-resectable hepatocellular carcinoma显示文摘瞄准:为病人评估经皮的乙醇注射(PEI ) 的治疗效果与先进, non-resectable HCC 与 transarterial chemoembolisation 的联合相比(不作声) 并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。方法:在学习时期期间接受了 PEI 治疗的所有病人根据物理地位和肿瘤程度被包括并且成层到下列治疗形式之一:联合不作声并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。包括Okuda分类,门静脉血栓的存在,腹水的存在,肿瘤的数字,最大的肿瘤直径,和假胆硷酯酶( CHE )的临床的参数的预示的价值,以及孩子呸上演, alpha-fetoprotein (法新社),发烧,复杂并发症的发生在这些组之间被估计并且比较。幸存用 Kaplan-Meier 被决定,多,变量回归分析。结果:所有病人的 1 年、 3 年的幸存是 73% 和 47% 。在亚群分析,联合不作声, PEI (1 ) 与更长的幸存被联系(1- , 3- , 5 年的幸存:90% , 52% ,和 43%) 与 PEI 治疗相比独自一个(2 )(1- , 3- , 5 年的幸存:65% , 50% ,和 37%) 。(3 ) 在起始的层化以后的第二等的 PEI 产出可比较的结果不作声(1- , 3- , 5 年的幸存:91% , 40% ,和 30%) 当在到最好的支持的照顾(4 ) 的层化以后的 PEI 与减少的幸存被联系时(1- , 3- , 5 年的幸存:50% , 23% , 12%) 。除了选择治疗形式,为更好的幸存的预言者是肿瘤数字(n <
5 ) ,肿瘤尺寸(<
5 厘米) ,在 PEI 前的没有腹水,和在 PEI 以后的稳定的假胆硷酯酶(P <
0.05 ) 。在在 PEI 以后的 2 wk 以内的死亡是 2.8%(n = 3 ) 。有 24 (8.9%) 主修在包括部分肝梗塞,焦点的肝坏死,和肝脓肿的 PEI 以后的复杂并发症。所有复杂并发症能非通过手术被管理。结论:重复单个会议的 PEI 在有以可接受、可管理的复杂并发症率的先进 HCC 的病人是有效的。病人们成层到联合不作声, PEI 能比那些独自成层到重复 PEI 期望更长的幸存。而且,有在好临床的地位的大或多重的肿瘤的病人可以也从联合获利不作声并且为第二等的 PEI 的再考虑。 | Arne Dettmer Timm D Kirchhoff Michael Gebel Lars Zender Nisar P Malek Bernhard Panning Ajay Chavan Herbert Rosenthal Stefan Kubicka Susanne Krusche Sonja Merkesdal Michael Galanski Michael P Manns Joerg S Bleck | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 3 | 酶在皮革工业中的应用综述显示文摘当今皮革行业面临着新的挑战,包括改善和优化生产过程来满足皮革制品对皮革质量的要求,以及遵循环保法规的相关规定。酶处理皮革是一项非常有前途的技术。酶是有机物质,通常是蛋白质,作为一种生物催化剂能催化复杂的化学反应。酶广泛应用于洗涤剂、食品、医药、精细化工等行业。通常,理想的酶源是微生物。一些研究报导酶用于皮革生产的不同阶段,能够减少在脱毛和浸灰过程中化学品的使用,甚至有报导称酶可以完全替代化学品。一些学者将酶用于染浴过程中来提高染料吸收率和用于鞣制过程来提高鞣制效率。一种新酶的鉴定是一个漫长的过程,需要筛选和分离出符合特定条件的新细菌,并且掌握所选微生物生长所需的营养和其他必要条件。酶应用于制革生产过程中,相关参数如pH、温度和产物对酶的抑制作用等影响,应该做进一步的研究。 | ALINE DETTMER PATRICIA SCHACKER DOS ANJOS MARILIZ GUTTERRES 杜卫宁 | 2013 | 西部皮革2013，，22： | 4 |
| 4 | Mass spectrometry-basedmetabolomics显示文摘 | Dettmer K Aronov PA Hammock BD | 2007 | Mass Spectrom Rev2007，26，1： | 1 |
| 5 | Lactic acid and acidificationinhibit TNF secretion and glycolysis of human monocytes 显示文摘 | Dietl K Renner K Dettmer K | 2010 | JImmunol2010，184，3： | 1 |
| 6 | Distributed form of constraint-induced movement therapy improves functional outcome and quality of life after stroke显示文摘 | Dettmers C Teske U Hamzei F | 2005 | Arch Phys Med Rehabil2005，86，： | 1 |
| 7 | Action of rat liver cathepsin L on glucagons 显示文摘 | Kargel H J Dettmer R Etzold G | 1981 | Acta Biol Med Ger1981，40，9： | 1 |
| 8 | Abnormal motor cortex organization contralateral to early upper limb amputation in humans显示文摘 | Dettmers C Liepert J Adler T | 1999 | Neurosci Lett1999，263，1： | 1 |
| 9 | The Heart of a New Machine: Powerformer is a Radically New Generator Design that Could Herald a New Era in a High Voltage Generation显示文摘 | DETTMER Roger | 1998 | IEE Review with IEE News1998，44，6： | 1 |
| 10 | Distributed form of constraint-induced movement therapy improves functional outcome and quality of life after stroke显示文摘 | Dettmers C Teske U Hamzer F | 2005 | Arch Phys Med Rehabil2005，86，： | 1 |
| 11 | Motor excitability changes during ac- tion observation in stroke patients 显示文摘 | Liepert J Greiner J Dettmers C | 2014 | J Rehabil Med2014，46，5： | 1 |
| 12 | Using DORIS Measurements for Modeling the Vertical Total Electron Content of the Earthg Ionosphere 显示文摘 | Denise Dettmering Marco Limberger Michael Schmidt | 2014 | JGeod2014，88，： | 1 |
| 13 | The Nicastrin-likeprotein Nicalin regulates assembly and stability of theNicalin-nodal modulator (NOMO) membrane protein com-plex显示文摘 | Haffner C Dettmer U Weiler T | 2007 | J Biol Chem2007，282，10： | 1 |
| 14 | Steady-state thermal conductivity measurements of AlN and SiC substrate materials 显示文摘 | DETTMER E S ROMENESKO B M CHARLES JR H K | 1989 | Components Hybrids and Manufacturing Technology IEEE Transactions on1989，12，4： | 1 |
| 15 | Observation and execu- tion of upper-limb movements as a tool for rehabilitation of motor defi- cits in paretic stroke patients: protocol of a randomized clinical trial 显示文摘 | Ertelt D Hemmelmann C Dettmers C | 2012 | BMC Neurol2012，12，： | 1 |
| 16 | Short message gets longer显示文摘 | Dettmer R | 1997 | IEE Review1997，，05： | 1 |
| 17 | Automated GC-MS analysis of free amino acids in biological fluids显示文摘 | KASPAR H DETTMER K GRONWALD W | 2008 | Journal of Chromatography B2008，870，2： | 1 |
| 18 | Mass-spectrometrybased metabolomics显示文摘 | DETTMER K ARONOV P A HAMMOCK B D | 2007 | Mass Spectrometry Reviews2007，26，： | 1 |
| 19 | LPS-binding pro-tein protects mice from septic shock caused by LPS or gram-nega-tive baeteria显示文摘 | Lamping N Dettmer R Schroder NW | 1998 | J Clin Invest1998，101，10： | 1 |
| 20 | A computational framework for fluid-rigid body interaction: finite element formulation and applications 显示文摘 | Dettmer W Perie D | 2006 | Comput Mechods Appl Mech Engrg2006，195，： | 1 |
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