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| 1 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 2 | Enteric neuropathology of congenital intestinal obstruction:A case report显示文摘试验性的证据显示肠的长期的机械亚吸藏可以损坏伤寒神经系统(ENS ) ,尽管在人的数据正在缺乏。我们这里描述伤寒的第一诉讼与内脏的先天的阻塞有关的退化神经病。3 年的 A 和老女孩开始抱怨了呕吐的 9 瞬间,腹的扩张,有空气液体的便秘在飞机铺平腹的辐射学。她的随后的病历被 3 操作描绘:首先显示出的扩大 duodeno-jejunal 当闭塞的损害不在时循环;第二(2 年以后) 被执行获得扩大的肠的环的完整厚度的活体检视并且在组织病理学说揭示了 hyperganglionosis;第三(在 hyperganglionosis 以后的 9 年被识别) 揭示了 Ladd 被移开的乐队,联系内脏旋转不良被改正。完整厚度的活体检视显示出的重复 intraoperative 与 Cajal 的减少的空隙的房间一起的退化神经病在 Ladd 的乐队下面在阻塞和正常的神经与肌的层上面在扩大的环联网的伤寒。病人容忍了的在最近的外科以后的一年口头的喂并且很好,建议那先天(部分) 在人的小肠的机械阻塞能唤起类似于在肠的机械吸藏的动物模型发现的那些的 ENS 的进步适应变化。如此的 ENS 变化模仿在肠的伪阻塞观察的神经元畸形。 | Giovanni Di Nardo Vincenzo Stanghellini Salvatore Cucchiara Giovanni Barbara Gianandrea Pasquinelli Donatella Santini Cristina Felicani Gianluca Grazi Antonio D Pinna Rosanna Cogliandro Cesare Cremon Alessandra Gori Roberto Corinaldesi Kenton M Sanders Roberto De Giorgio | 2006 | World Journal of Gastroenterology2006，12，32： | 4 |
| 3 | Neurophysiologic follow-up of long-term dietary?Treatment in adult-onset adrenoleukodystrophy显示文摘 | Restuccis D Di Lazzaro V Valeriani M | 1999 | Neurology1999，，： | 2 |
| 4 | Effect of various surface modifications of wood flour on the properties of PP/wood composites显示文摘 | Lívia Dányádi János Móczó Béla Pukánszky | 2009 | Composites Part A2009，，2： | 2 |
| 5 | Reversible and resistant components of PCB adsorption-desorption: Isotherms 显示文摘 | Horzempa L M | 1982 | Environ Sci Technol1982，16，9： | 1 |
| 6 | Iodide excess induces apoptosis in thyroid cells through a p53-independent mechanism involving oxidative stress显示文摘 | Vitale M Di Matola T D'Ascoli F | 2000 | Endocrinology2000，141，2： | 1 |
| 7 | Molecular characterization of an endopolygalacturonase from Fusarium oxysporum expressed during early stages of infection显示文摘 | Garcia-Maceira F I DI Pietro A Huertas-Gonztles M D | 2001 | Applied and Environmental Microbiology2001，67，： | 1 |
| 8 | Study of liver function in healthy elderly subjects using the ^13C-methacetin breath test显示文摘 | Ciccocioppo R Candelli M Di Francesco D | 2003 | Aliment Pharmacol Ther2003，17，2： | 1 |
| 9 | Increased activity of the ubiquitin-proteasome system in patients with symptomatic carotid disease is associated with enhanced inflammation and may destabilize the atherosclerotic plaque: effects of rosiglitazone treatment显示文摘 | Marfella R D'Amico M Di Filippo C | 2006 | J Am Coil Cardio2006，47，12： | 1 |
| 10 | The possible role of the ubiquitin proteasome system in the development of atherosclerosis in diabetes显示文摘 | Marfella R D'Amico M Di Filippo C | | 0，，： | 1 |
| 11 | Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa显示文摘 | De Filippo C Cavalieri D Di Paola M | | 0，，： | 1 |
| 12 | CD28 ligation in the absence of TCR stimulation up-regulates IL-17A and pro-inflammatory cytokines in relapsing-remitting multiple sclerosis T lymphocytes显示文摘 | CamperioC Muscolini M Volpe E Di Mitri D | | 0，，14： | 1 |
| 13 | Massive bone al- lograft reconstruction in high-grade osteosacoma 显示文摘 | Donati D DI llddo M Zavatta M | 2000 | Clin Orthop Relat Res2000，，377： | 1 |
| 14 | IL-21 as a therapeutic target in inflammatory disorders显示文摘 | Di Fusco D Izzo R Figliuzzi M M | 2014 | Expert Opin Ther Targets2014，18，11： | 1 |
| 15 | Thoracic ky- phosis and ventilatory dysfunction in unselected older per- sons: an epidemiological study in Dicomano, Italy显示文摘 | Di Bari M Chiarlone M Matteuzzi D | 2004 | J Am Geriatr Soe2004，52，6： | 1 |
| 16 | Mycophenolate mofetil and roscovitine decrease cyclin expression and increase p27Kipl (Kip11) expression in anti Thyl mesangial proliferative nephritis显示文摘 | Chiara M Menegatti E Di Simone D | 2005 | Clin Exp Immunol2005，139，2： | 1 |
| 17 | Iodide excess induces apoptosis in thyroid cells through a p53-independ- ent mechanism involving oxidative stress 显示文摘 | Vitale M Di Matola T D'Ascoli F | 2000 | Endocrinol- ogy2000，141，2： | 1 |
| 18 | Toxicity of cadmium in sediments: the role of acid volatile sulfide 显示文摘 | Di Toro D M Mahony J D Hansen D J | 1990 | Environmental Toxicology and Chemistry1990，9，12： | 1 |
| 19 | Update on gingival overgrowth by cyelosporine A in renal transplants显示文摘 | Ciavarella D Guiglia R Campisi G Di Cosola M Di Liberto C Sabatucci A | 2007 | Med Oral Patol Oral Cir Bueal2007，12，： | 1 |
| 20 | Assessment of the angiotensin-I-converting enzyme (ACE-l) inhibitory and antioxidant activities of hydrolysates of bovine brisket sarcoplasmic proteins produced by papain and characterisation of associated bioactive peptidic fractions显示文摘 | DI BERNARDINI R MULLEN A M BOLTON D | 2012 | Meat science2012，90，1： | 1 |
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