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| 1 | Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer显示文摘AIM To investigate association of circulating inflammatory factors at the time of colorectal cancer(CRC) surgery with survival.METHODS Plasma levels from 174 CRC patients(69 females and 105 men), with median age 70 years(range 29-90), localized in the colon(n = 105) or rectum(n = 69), with stage Ⅰ(n = 24), stage Ⅱ(n = 54), stage Ⅲ(n = 67) and stage Ⅳ(n = 29) were measured using commercially available Bio-Plex Pro? Human Chemokine Panel 40-Plex, including 40 different chemokines, cytokines and interleukins. The prognostic association of each inflammatory factor was analysed as CRC-specific and total mortality.RESULTS Out of 174 patients, 66 died during the follow-up, 40 because of CRC specific mortality. High tertile levels of 8 factors were significantly associated with increased CRC-specific mortality, of which CCL1, CCL20, CCL24, CX3CL1, IL-4 and TNF-α remained significant in a multivariate Cox regression analysis. High tertile levels of 14 factors were associated with increased total mortality, of which CCL1, CCL15, CCL20, CX3CL1, CXCL13, IFN-γ, IL-2, IL-4 and IL-10 remained significant after adjustment for clinical covariates. For most of the inflammatory factors the association between higher tertile levels and an increased mortality in general appeared two years after surgery. High tertile levels of TNF-α and CCL24 were exclusively associated with CRC-specific mortality. The distribution of these factors were not associated with TNM stage with exception for CCL20.CONCLUSION High plasma levels of inflammatory factors are associated with increased risk of mortality among CRC patients and could be potential biomarkers for revealing prognosis. | Renate S Olsen Johnny Nijm Roland E Andersson Jan Dimberg Dick Wagsater | 2017 | World Journal of Gastroenterology2017，23，34： | 8 |
| 2 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 3 | Misdiagnosis of tuberculosis and the clinical relevance of nontuberculous mycobacteria in Zambia显示文摘Objective:To determine the accuracy of TB diagnosis of TB in Zambia in the era of increasing HIV prevalence.Methods:Sputum of the clinically diagnosed TB cases was additionally subjected to liquid culture and molecular identification.This study distinguished between TB cases confirmed by positive Mycobacterium tuberculosis(M.tuberculosis) cultures and mycobacterial disease caused by non-tuberculous mycobacteria(NTM).Results:Only 49% of the 173 presumptively diagnosed TB cases was M.tuberculosis cultured,while in 13% (22) cases,a combination of M.tuberculosis and NTM was found.In 18% of the patients only NTM were cultured.In 28% ,no mycobacteria was cultivable.HIV positive status was correlated with the isolation of NTM(P<0.05).Conclusions:The diagnosis of tuberculosis based on symptoms, sputum smear and/or chest X-ray leads to significant numbers of false-positive TB cases in Zambia,most likely due to the increased prevalence of HIV.The role of NTM in tuberculosislike disease also seems relevant to the false diagnosis of TB in Zambia. | Patricia CAM Buijtels Michael D Iseman Shelagh Parkinson Cas S de Graaff Henri A Verbrugh Pieter LC Petit Dick van Soolingen | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，5： | 2 |
| 4 | Catalytic aspects of the steam reforming of hydrocarbons in in- ternal reforming fuel cells显示文摘 | Clarke S H Dicks A L Pointon K | 1997 | Catalysis Today1997，38，： | 1 |
| 5 | Catalytic spans of the steam reforming of hydrocarbons in internal reforming fuel cells显示文摘 | CLARKE S H DICKS A L POINTON K | 1997 | Catal Today1997，38，4： | 1 |
| 6 | Customer Loyalty:Toward and Integrated Conceptual Framework 显示文摘 | Dick A S Basu K | 1994 | Journal-of -Academy of Marketing Science1994，22，： | 1 |
| 7 | Balloon angioplasty versus stenting with nitinol stents in intermediate length superficial femoral artery lesions显示文摘 | Dick P Wallner H Sabeti S | 2009 | Catheter Cardiovasc Interv2009，74，1： | 1 |
| 8 | Effective prevention and therapy of experimental allergic asthma using a GATA-3-specific DNAzyme 显示文摘 | Sel S Wegmann M Dicke T | 2008 | J Allergy Clin Immunol2008，121，4： | 1 |
| 9 | Quantitive C Characterization of Trace Levels of PFOS and PFOA in the Tennesse River显示文摘 | Hansen K J Johnson H O Eldridge J S Butenhoff J L Dick L A | 2002 | Environ Sci Technol2002，36，8： | 1 |
| 10 | Consensus statement on definitions of disease,end poients,and therapeutic response for pemphigus显示文摘 | Murrell DF Dick S Ahmed AR | 2008 | J Am Acad Dermatol2008，58，6： | 1 |
| 11 | Long-segment SFA stenting--the dark sides:in-stent restenosis,clinical deterioration,and stent fractures显示文摘 | Schlager O Dick P Sabeti S | | 0，，06： | 1 |
| 12 | Effective prevention and therapy of experimental allergic asthma using a GATA-3-specifie DNAzyme 显示文摘 | Sel S Wegmann M Dicke T | 2008 | J Allergy Clin Immunol2008，121，4： | 1 |
| 13 | Transient Ground Potential Rise in Gas Insulated Subs- tations - Experimental Studies 显示文摘 | FUJIMOTO N DICK E P BOGGS S A FORD G L | 1982 | IEEE Trans on Power Apparatus and Systems1982，101，1： | 1 |
| 14 | Phacoemulsification and vitrectomy with the erbium:YAG laser and phacoemulsification with the neodymium:YAG laser显示文摘 | Dick HB Kaskel S Hoh H | 2001 | Ophthalmology2001，98，9： | 1 |
| 15 | Customer loyalty:Toward an integrated conceptual framework 显示文摘 | Dick A S Basu K | 1994 | Journal of the Academy of Marketing Science1994，22，2： | 1 |
| 16 | Customer loyalty:toward an integrated conceptual framework显示文摘 | DICK A S BASU K | | 0，，： | 1 |
| 17 | Sustained benefit at 2 years of primary femoropopliteal stenting compared with balloon angioplasty with optional stenting显示文摘 | Schillinger M Sabeti S Dick P | 2007 | Circulation2007，115，21： | 1 |
| 18 | Jasmonate-deficient plants have reduced direct and indirect defences against herbivores 显示文摘 | Thaler J S Farag M A Dicke M | 2002 | Ecology Letters2002，5，： | 1 |
| 19 | Customer loyalty: Towards and integratedconceptual framework 显示文摘 | Dick G S Basu K | 1994 | Journal of the Academy of Marketing Science1994，22，2： | 1 |
| 20 | Customer Loyalty: Toward an Integrated Conceptual Framework显示文摘 | Dick A S Basu K | 1994 | Journal of the Academy of Marketing Science1994，22，2： | 1 |
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