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| 1 | 高脂饮食诱导的肠道微生物代谢障碍对精子发生和精子运动的损害显示文摘1973至2011年间西方国家男性精子密度快速下降50%以上,且当前无有效治疗方法减缓其下降趋势。越来越多的临床研究及动物实验表明,高脂饮食介导的肥胖、代谢综合征可以重塑肠道菌群,继而影响能量代谢、肠道黏膜屏障、宿主免疫、预防病原菌等生理功能。为了解高脂饮食是否通过肠道菌群影响男性生殖,该研究分别将正常饮食喂养的小鼠肠道菌群移植入6只正常饮食小鼠(组1),高脂饮食喂养的小鼠肠道菌群移植入另外6只正常饮食小鼠(组2)体内,15周后,检测到组2小鼠的精子生成、精子运动、曲细精管内精原干细胞数量、精母细胞数量均显著下降,血液内毒素升高近2倍,但组1小鼠的上述指标无明显改变。 | Ding N Zhang X Zhang XD 季文(编译) | 2020 | 中华医学杂志2020，100，26： | 25 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | The Effects of the Chemical Components of Soil Salinity on Electrical Conductivity in the Region of the Delta Oasis of Weigan and Kuqa Rivers,China显示文摘In order to assess the effects of chemical properties of soil salinity on electrical conductivity of 1:5 soil/water extract (EC1:5), the study focused on revealing the main chemical factors contributing to EC of soil extracts and their relative importance. The relationship between EC1:5 and the chemical properties of soil salinity in the delta oasis of Weigan and Kuqa rivers, China, were studied using path coefficient analysis, a path analysis method. We studied each key element affecting EC1:5 either directly or indirectly. The results obtained show that the salt content, total dissolved solids (TDS), and the sum of the sodium ion concentration and the kalium ion concentration are the most influential factors on 1:5 soil/ water extract (EC1:5) in the 0-10 cm and the 30-50 cm soil layer. The results show that the sequence of direct path coefficients in the 0-10 cm and the 30-50 cm soil layers on soil conductivity is TDS→Na+ + K+→Salt content→Ca2+→Cl-→the sodium dianion ratio (SDR)→pH→SO42-→HCO3-→Mg2+→the soluble sodium percentage (SSP)→sodium absorption ratio (SAR) and TDS→Salt content→Na+ + K+→Ca2+→SDR→Mg2+→HCO3-→SSP→pH→SO42-→SAR→Cl-. The salt content, chlorine ion, and SAR are the main factors affecting 1:5 soil/water extract (EC1:5) in the 10-30 centimeter soil layer. The order of direct path coefficients result is as follows: Salt content→Cl-→SAR→SSP→TDS→Ca2+→Mg2+ = SO42-→HCO3-→pH→SDR→Na+ + K+. Moreover, the effects of HCO3-, pH were very weak. Though the direct path coefficients between EC1:5 and SAR, SO42- and Ca2+ were not high, influence of other chemical factors caused the coefficients to increase, making the summation of their direct and indirect path coefficients relatively high. The models of the different soil layers were structured separately. Evidences showed that multiple regression relations between EC1:5 and most of the primary factors had sound reliability and very good accuracy. The research results can serve as a reference to the scientific management amelioration and utilization of saline in the Delta Oasis of Weigan and Kuqa rivers. | ZHANG Fei Tashpolat Tiyip DING Jian-li Gregory N Taff HE Qi-sheng | 2009 | Agricultural Sciences in China2009，8，8： | 4 |
| 4 | Increased nitric oxide inactivation by reactive oxygen species in Lead - induced hypertension 显示文摘 | Vaziri N D Liang KH Ding YX | 1999 | Kidney Int1999，56，： | 3 |
| 5 | Adaptive iso-planar tool path generation for machining of free- form surfaces 显示文摘 | DING S MANNAN M A POO A N | 2003 | Computer-Aided Design2003，35，2： | 1 |
| 6 | FP-projective dimensions显示文摘 | MAO L X DING N Q | 2005 | Communications in Algebra2005，33，： | 1 |
| 7 | Symmetry-related growth of car- bon nanocoils from Ni based alloy particles 显示文摘 | Ding D Y Wang J N Dozer A | 2004 | Journal of Ap- plied Physics2004，95，9： | 1 |
| 8 | On general principally injective rings显示文摘 | CHEN J L DING N Q | 1999 | Communications in Algebra1999，27，5： | 1 |
| 9 | Thirty-year manuring and fertilization ef- fects on heavy metals in black soil and soil aggregates in Northeastern China显示文摘 | Fan J L Ding W X Ziadi N | 2013 | Communications in Soil Science and Plant Analysis2013，44，： | 1 |
| 10 | On copure flat modules and copure flat resolvents显示文摘 | DING N Q CHEN J L | 1996 | Conununications in Algebra1996，24，3： | 1 |
| 11 | On (m,n)-injectivity of modules显示文摘 | CHEN J L DING N Q LI Y L | 2001 | Comm Algebra2001，29，12： | 1 |
| 12 | Ethanol impaired neuronal migration is associated with reduced aspartyl-asparaginylbeta-hydroxylase expression显示文摘 | Carter J J Tong M Silbermann E Lahousse S A Ding F F Longato L Roper N Wands J R | | 0，，03： | 1 |
| 13 | Electrochemical sensor for detection of p-nitrophenol based on nanoporous gold显示文摘 | Liu Z N Du J G Qiu C C Huang L H Ma H Y Shen D Z Ding Y | | 0，，07： | 1 |
| 14 | Cross-layer routing and dynamic spectrum allocation in cognitive radio Ad hoc networks显示文摘 | DING Lei MELODIA T BATALAMA S N | | 0，，04： | 1 |
| 15 | Structure-activity relationships of saponin derivatives : a series of entry inhibitors for highly patho- genic H5N1 influenza virus 显示文摘 | Ding N Chen Q Zhang W | 2012 | Eur J Med Chem2012，53，4： | 1 |
| 16 | Clinical evaluation of the efficacy of the combination of anenrysm embolization and cerebrospinal fluid replacement in the treatment of anenrysmal subarachnoid hemorrhage 显示文摘 | Ding W Gao N Li MX | 2015 | Eur Rev Med Pharmacol Sci2015，19，3： | 1 |
| 17 | Arsenic trioxide synergizes with everolimus (Rad001) to induce cytotoxicity of ovarian cancer cells through increased autophagy and apoptosis 显示文摘 | Liu N Tai S Ding B | 2012 | Endocrine-related Cancer2012，19，5： | 1 |
| 18 | On strongly copure flat modules and copure fiat dimensions 显示文摘 | FU X H DING N Q | 2010 | Communications in Algebra2010，38，12： | 1 |
| 19 | MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expression显示文摘 | Ding N Tomomori-Sato C Sato S | 2009 | J Biol Chem2009，284，5： | 1 |
| 20 | On the thermal stability of coating in an Al18B4O33w/α-Al2O3/6061Al composite显示文摘 | Ding D Y Wang J N Ning C Q | 2003 | Materials Science and Engineering A2003，358，12： | 1 |
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