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| 1 | Metastasized pancreatic carcinoma with neoadjuvant FOLFIRINOX therapy and R0 resection显示文摘Patients with metastasized carcinoma of the pancreas have a very poor prognosis, and long-term survival cannot be expected. This case report describes two patients with an initial diagnosis of metastatic pancreatic cancer, both with hepatic metastases and one with an additional peritoneal carcinomatosis. Initially, both patients were treated intravenously with the FOLFIRINOX chemotherapy regimen, consisting of 5-FU, folinic acid, irinotecan and oxaliplatin. Surprisingly, the FOLFIRINOX treatment resulted in complete resolution of the hepatic metastases in both patients, with no lesions detectable by computed tomography scan. Furthermore, treatment response included decreased diameter of the primary tumor in the tail of the pancreas and disappearance of the additional peritoneal carcinomatosis. Both patients were discussed by our multidisciplinary tumor board, which recommended surgical resections of the carcinoma. The R0 resection of the primary tumor was successful in both cases and, interestingly, the resected tissues showed no evidence of the hepatic metastases intraoperatively. In the first case, the patient received a postoperative 6-mo course of adjuvant chemotherapy with gemcitabine. In the second case, the patient continued to receive the FOLFIRINOX regimen for an additional 6 mo postoperatively. At 12 mo after the operation, a nonresectable retroperitoneal lymph node metastasis was detected in the first patient, whereas the second patient remained in complete remission at the time of this report(5 mo after the adjuvant therapy was discontinued). This case report is the first of its kind to describe two cases of hepatic metastatic pancreatic carcinoma that were resectable following treatment with FOLFIRINOX. Further studies are required to examine the role of FOLFIRINOX as a neoadjuvant treatment option in subgroups of patients with initially metastasized pancreatic carcinoma. | Sophie Schneitler Patric Krpil Jasmin Riemer Gerald Antoch Wolfram Trudo Knoefel Dieter Hussinger Dirk Graf | 2015 | World Journal of Gastroenterology2015，21，20： | 9 |
| 2 | Regional lymphadenectomy strongly recommended in T1b gallbladder cancer显示文摘This article discusses the adequate treatment of early gallbladder cancer(T1a,T1b) and is based on published studies extending over nearly 3 decades.Randomized studies and meta analyses comparing different surgical treatments do not exist.The literature shows that in up to 20% of patients lymph node metastasis are found in T1b gallbladder cancer.Due to high malignancy with early angiolymphatic spread and resistance to chemotherapy and radiation on the one hand,and the relative low operative risk of extended cholecystectomy(cholecystectomy and regional lymphadenectomy) on the other hand,we believe that this procedure is mandatory in early gallbladder cancer. | Ulrich Klaus Fetzner Arnulf H Hlscher Dirk L Stippel | 2011 | World Journal of Gastroenterology2011，17，38： | 8 |
| 3 | 霉菌毒素及脱毒方法概述显示文摘 | Dirk Hhler 马玺 赵玉华 | 2000 | 国外畜牧科技2000，27，4： | 5 |
| 4 | Nighttime sap flow of Acacia mangium and its implications for nighttime transpiration and stem water storage显示文摘Aims Nighttime sap flow of trees may indicate transpiration and/or recharge of stem water storage at night.This paper deals with the water use of Acacia mangium at night in the hilly lands of subtropical South China.Our primary goal was to reveal and understand the nature of nighttime sap flow and its functional significance.Methods Granier’s thermal dissipation method was used to determine the nighttime sap flux of A.mangium.Gas exchange system was used to estimate nighttime leaf transpiration and stomatal conductance of studied trees.Important Findings Nighttimesap flowwas substantial and showed seasonal variation similar to the patterns of daytime sap flowin A.mangium.Mean nighttime sap flow was higher in the less precipitation year of 2004(1122.4 mm)than in the more precipitation year of 2005(1342.5 mm)since more daytime transpiration and low soil water availability in the relatively dry 2004 can be the cause of more nighttime sap flow.Although vapor pressure deficit and air temperature were significantly correlated with nighttime sap flow,they could only explain a small fraction of the variance in nighttime sap flow.The total accumulated water loss(E_(L))by transpiration of canopy leaves was only;2.6–8.5%of the total nighttime sap flow(E_(t))during the nights of July 17–18 and 18–19,2006.Therefore,it is likely that the nighttime sap flow was mainly used for refillingwater in the trunk.The stem diameter at breast height,basal area and sapwood area explained much more variance of nighttime water recharge than environmental factors and other tree form features,such as tree height,stem length below the branch,and canopy size.The contribution of nighttime water recharge to the total transpiration ranged from 14.7 to 30.3%depending on different DBH class and was considerably higher in the dry season compared to the wet season. | Hua Wang Ping Zhao Dirk Hölscher Quan Wang Ping Lu Xi A.Cai Xiao P.Zeng | 2012 | Journal of Plant Ecology2012，5，3： | 5 |
| 5 | Prediction of delayed graft function using different scoring algorithms: A single-center experience显示文摘AIM To compare the performance of 3 published delayed graftfunction(DGF) calculators that compute the theoretical risk of DGF for each patient.METHODS This single-center,retrospective study included 247 consecutive kidney transplants from a deceased donor.These kidney transplantations were performed at our institution between January 2003 and December 2012.We compared the occurrence of observed DGF in our cohort with the predicted DGF according to three different published calculators. The accuracy of the calculators was evaluated by means of the c-index(receiver operating characteristic curve).RESULTS DGF occurred in 15.3% of the transplants under study.The c index of the Irish calculator provided an area under the curve(AUC) of 0.69 indicating an acceptable level of prediction,in contrast to the poor performance of the Jeldres nomogram(AUC = 0.54) and the Chapal nomogram(AUC = 0.51). With the Irish algorithm the predicted DGF risk and the observed DGF probabilities were close. The mean calculated DGF risk was significantly different between DGF-positive and DGF-negative subjects(P < 0.0001). However,at the level of the individual patient the calculated risk of DGF overlapped very widely with ranges from 10% to 51% for recipients with DGF and from 4% to 56% for those without DGF.The sensitivity,specificity and positive predictive value of a calculated DGF risk ≥ 30% with the Irish nomogram were 32%,91% and 38%. CONCLUSION Predictive models for DGF after kidney transplantation are performant in the population in which they were derived,but less so in external validations. | Magda Michalak Kristien Wouters Erik Fransen Rachel Hellemans Amaryllis H Van Craenenbroeck Marie M Couttenye Bart Bracke Dirk K Ysebaert Vera Hartman Kathleen De Greef Thiery Chapelle Geert Roeyen Gerda Van Beeumen Marie-Paule Emonds Daniel Abramowicz Jean-Louis Bosmans | 2017 | World Journal of Transplantation2017，7，5： | 3 |
| 6 | Simultaneous occurrence of a hepatocellular carcinoma and a hepatic non-Hodgkin's lymphoma infi ltration显示文摘To investigate the simultaneous occurrence of hepatocellular carcinoma and non-Hodgkin's lymphoma, we report the case of a 70 year old patient with a primary diagnosis of non-Hodgkin's lymphoma in 2002. In a routine follow up investigation of his chronic lymphocytic leukemia a newly detected mass in the Couinaud's segments 2 and 3 was found. No hepatitis C virus or hepatitis B virus infection or cirrhosis was evident. After laparoscopic segmentectomy the histological examination revealed a hepatocellular carcinoma. While the relation between liver parenchyma damages and hepatocellular carcinoma or non-Hodgkin's lymphoma is well known, only a few publications have focused on the coexistence of hepatocellular carcinoma and non-Hodgkin's lymphoma. With this case we demonstrate the coexistence of these diseases without having a pre- damaged liver parenchyma. | Sabine Heidecke Dirk L Stippel Arnulf H Hoelscher Inga Wedemeyer Hans-Peter Dienes Uta Drebber | 2010 | World Journal of Hepatology2010，2，6： | 2 |
| 7 | Efficient photon coupling from a diamond nitrogen vacancy center by integration with silica fiber显示文摘A central goal in quantum information science is to efficiently interface photons with single optical modes for quantum networking and distributed quantum computing.Here,we introduce and experimentally demonstrate a compact and efficient method for the low-loss coupling of a solid-state qubit,the nitrogen vacancy(NV)center in diamond,with a single-mode optical fiber.In this approach,single-mode tapered diamond waveguides containing exactly one high quality NV memory are selected and integrated on tapered silica fibers.Numerical optimization of an adiabatic coupler indicates that near-unity-efficiency photon transfer is possible between the two modes.Experimentally,we find an overall collection efficiency between 16%and 37%and estimate a single photon count rate at saturation above 700 kHz.This integrated system enables robust,alignment-free,and efficient interfacing of single-mode optical fibers with single photon emitters and quantum memories in solids. | Rishi N Patel Tim Schröder Noel Wan Luozhou Li Sara L Mouradian Edward H Chen Dirk R Englund | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 8 | Kontrastmittelsonografie bei B-Bild-morphologisch unklaren Leberraumforderungen – Diagnostische Treffsicherheit im klinischen Alltag (DEGUM-Multicenter – Studie)显示文摘 | D Strobel K Seitz W Blank A Schuler C Dietrich A Herbay M Friedrich-Rust G Kunze D Becker U Will W Kratzer F Albert C Pachmann K Dirks H Strunk C Greis T Bernatik | 2008 | Ultraschall in Med2008，，05： | 2 |
| 9 | Elevated C - reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease 显示文摘 | Fichtlscherer S Rosenberer G Dirk H | 2000 | Circulation2000，102，： | 1 |
| 10 | Tumor necrosis factor receptor-associated factor(TRAF)4 is a new binding partner for the p70S6 serine/threonine kinase显示文摘 | Fleckenstein D S Dirks W G Drexler H G | 2003 | Leuk Res2003，27，8： | 1 |
| 11 | Adrenaline:relationship be- tween infusion rate, plasma concentration, metabolic and hemody- namic effects in volunteers显示文摘 | Ensinger H Lindner KH Dirks B | 1992 | Eur Anaesthesiol1992，9，6： | 1 |
| 12 | The deformational history of the Larsemann Hills,Prydz Bay:the importance of the Pan-African (500 Ma) in East Antarctica显示文摘 | Dirks P H G M Carson C J Wilson C J L | 1993 | Antarctic Science1993，5，2： | 1 |
| 13 | Cryptochromes and neuronal-activity markers colocalize in the retina of migratory birds during magnetic orientation显示文摘 | Mouritsen H Janssen-Bienhold J Liedvogel M Feenders G Stalleicken J Dirks P Weiler R | | 0，，： | 1 |
| 14 | Clinical efficacy of cardiac resynchronization therapy using left ventricular pacing in heart failure patients stratified by severity of ventricular conduction delay显示文摘 | Angelo Auricchio Christoph Stellbrink Christian Butter Stefan Sack Jürgen Vogt Anand Ramdat Misier Dirk B?cker Michael Block Johannes H Kirkels Andrew Kramer Etienne Huvelle | 2003 | Journal of the American College of Cardiology2003，，12： | 1 |
| 15 | A software-based highquality MPEG-2 encoder employing scene change detection and adapfve quantization显示文摘 | DIRK F NIELS M PETER H N | 2001 | IEEE ICCE Digest2001，，： | 1 |
| 16 | HVC set to move on to multi-level PM applications显示文摘 | DIRK S | 2005 | Metal Powder Report2005，60，5： | 1 |
| 17 | SAMPEG,a scene adaptive,parallel MPEG-2 software encoder 显示文摘 | DIRK F NIEIS M PETER H N | 2001 | SPIE Visual Communications and Image Processing2001，43，10： | 1 |
| 18 | Elevated C reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease 显示文摘 | Iehtlscherer S Rosenherer G Dirk H | 2000 | Circulation2000，102，13： | 1 |
| 19 | Randomised comparison of epinephrine and vasopressin in patients with out-of-hospital ventvicular fibrillation显示文摘 | LINDNER K H DIRKS B STROHMENGER H U | 1997 | Lancet1997，349，： | 1 |
| 20 | Fish and immunoeytoehemistry: towards visualising single target molecules in living ceils 显示文摘 | Tanke H J Dirks R W | 2005 | Current Opinion in Biotechnology2005，16，1： | 1 |
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