|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 2 | Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study显示文摘 | Hedy L Kindler Tatsuya Ioka Dirk J Richel Jaafar Bennouna Richard Létourneau Takuji Okusaka Akihiro Funakoshi Junji Furuse Young Suk Park Shinichi Ohkawa Gregory M Springett Harpreet S Wasan Peter C Trask Paul Bycott Alejandro D Ricart Sinil Kim Eric Van | 2011 | Lancet Oncology2011，，3： | 4 |
| 3 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 4 | Kontrastmittelsonografie bei B-Bild-morphologisch unklaren Leberraumforderungen – Diagnostische Treffsicherheit im klinischen Alltag (DEGUM-Multicenter – Studie)显示文摘 | D Strobel K Seitz W Blank A Schuler C Dietrich A Herbay M Friedrich-Rust G Kunze D Becker U Will W Kratzer F Albert C Pachmann K Dirks H Strunk C Greis T Bernatik | 2008 | Ultraschall in Med2008，，05： | 2 |
| 5 | Experiments and modeling ofanisotropic aluminum extrusions under multi-axial loading-PartII: Ductile fracture显示文摘 | Luo M Matthieu D Dirk M | | International Journal of0，11，35： | 1 |
| 6 | Galacto mannan, soluble sugar, and starch mobilization following germination of Trigonella foenum graeculy L seeds 显示文摘 | Dirk L M A vanderkrol A R Vreugdenhil D | 1999 | Plant Physiology and Biochemistry1999，37，： | 1 |
| 7 | Assess-ment of C budget for grasslands and drylands of the world显示文摘 | Ojima D S Dirk B 0 M Gleovn E P | 1993 | Water Air Soil Pollut1993，70，： | 1 |
| 8 | Photoemission study of onion like quantum dot quantum well and double quantum well nanocrystals of CdS and HgS显示文摘 | Holger B Dirk D Colm M | 2003 | J Phys Chem2003，107，： | 1 |
| 9 | Assessment of C budget for grasslands and dry lands of the world 显示文摘 | OJIMA D S DIRKS B O M GLEOVEN E P | 1993 | Water Soil Poll1993，70，： | 1 |
| 10 | Assessment of C budget for grasslands and drylands of the world显示文摘 | Dirk B O M Gleovn E P Owensby C E | 1993 | Water Air Soil Pollut1993，70，： | 1 |
| 11 | Assessment of C budget for grasslands and dry lands of the world显示文摘 | Ojima D S Dirks B O M Gleovn E P | 1993 | Water Air and Soil Pollution1993，70，： | 1 |
| 12 | Spermatogonial stem cells: characteristics and experimental possibilities显示文摘 | Pedro M A Maaike A V Dirk D R | 2005 | APMIS2005，113，： | 1 |
| 13 | Microvascular ischemia reperfusion injttry in striated muscle: significance of 'reflow paradox' 显示文摘 | Menger M D Stefan P Dirk S | 1992 | Am J Physiol1992，263，： | 1 |
| 14 | Effects of sleep on the production of cytokines in humans 显示文摘 | Uthgenannt Dirk M D Schoolmann Detlef M D | 1995 | Psychosom Med1995，57，2： | 1 |
| 15 | Neissefial pofin (PorB) canses rapid calcium influx in target ceils and induces apoptesis by the activation of cysteine proteases显示文摘 | Anne M Dirk G Frank D | 1999 | EMBO J1999，18，2： | 1 |
| 16 | Habitat quality and biodiversity indicator perform- maces of a threatened butterfly versus a multispecies group for wet heathlmads in Belgium 显示文摘 | Dirk M Hans V D | 2004 | Biological Conservation2004，123，2： | 1 |
| 17 | Assessment of C budget for grasslands and drylands of the world显示文摘 | OJIMA D S DIRK B O M GLEOVN E P | 1993 | Water Air and Soil Pollution1993，70，： | 1 |
| 18 | Modelling non-stationary dynamic gene regulatory processes with the BGM model显示文摘 | Grzegorczyk M Dirk Husmeier D Rahnenführer J | | 0，，02： | 1 |
| 19 | Plant L-ascorbic acid:chemistry,function,metabolism,bioavailability and effects of processing显示文摘 | Mark W D Marc V M Dirk I | 2000 | Sci Food Agric2000，80，： | 1 |
| 20 | Assessment of C budget for grasslands and dry lands of the world显示文摘 | Ojima D S Dirks B O M Glenn E P | 1993 | Water Air Soil Pollution1993，70，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员