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| 1 | AU-rich element-binding proteins in colorectal cancer显示文摘Trans-acting factors controlling mRNA fate are critical for the post-transcriptional regulation of inflammation-related genes, as well as for oncogene and tumor suppressor expression in human cancers. Among them, a group of RNA-binding proteins called 'Adenylate-Uridylate-rich elements binding proteins'(AUBPs)control mRNA stability or translation through their binding to AU-rich elements enriched in the 3'UTRs of inflammation-and cancer-associated mRNA transcripts. AUBPs play a central role in the recruitment of target mRNAs into small cytoplasmic foci called Processing-bodies and stress granules(also known as P-body/SG). Alterations in the expression and activities of AUBPs and Pbody/SG assembly have been observed to occur with colorectal cancer(CRC)progression, indicating the significant role AUBP-dependent post-transcriptional regulation plays in controlling gene expression during CRC tumorigenesis.Accordingly, these alterations contribute to the pathological expression of many early-response genes involved in prostaglandin biosynthesis and inflammation,along with key oncogenic pathways. In this review, we summarize the current role of these proteins in CRC development. CRC remains a major cause of cancer mortality worldwide and, therefore, targeting these AUBPs to restore efficient post-transcriptional regulation of gene expression may represent an appealing therapeutic strategy. | Noémie Legrand Dan A Dixon Cyril Sobolewski | 2019 | World Journal of Gastrointestinal Oncology2019，11，2： | 7 |
| 2 | Stress granules in colorectal cancer:Current knowledge and potential therapeutic applications显示文摘Stress granules(SGs)represent important non-membrane cytoplasmic compartments,involved in cellular adaptation to various stressful conditions(e.g.,hypoxia,nutrient deprivation,oxidative stress).These granules contain several scaffold proteins and RNA-binding proteins,which bind to mRNAs and keep them translationally silent while protecting them from harmful conditions.Although the role of SGs in cancer development is still poorly known and vary between cancer types,increasing evidence indicate that the expression and/or the activity of several key SGs components are deregulated in colorectal tumors but also in pre-neoplastic conditions(e.g.,inflammatory bowel disease),thus suggesting a potential role in the onset of colorectal cancer(CRC).It is therefore believed that SGs formation importantly contributes to various steps of colorectal tumorigenesis but also in chemoresistance.As CRC is the third most frequent cancer and one of the leading causes of cancer mortality worldwide,development of new therapeutic targets is needed to offset the development of chemoresistance and formation of metastasis.Abolishing SGs assembly may therefore represent an appealing therapeutic strategy to re-sensitize colon cancer cells to anti-cancer chemotherapies.In this review,we summarize the current knowledge on SGs in colorectal cancer and the potential therapeutic strategies that could be employed to target them. | Noémie Legrand Dan A Dixon Cyril Sobolewski | 2020 | World Journal of Gastroenterology2020，26，35： | 4 |
| 3 | Respose of ectomycorrhizal Pinus banksiana and Picea glauca to heavy metals in soil显示文摘 | Dixon P K Bushena C A | 1988 | Plant and Soil1988，105，1： | 2 |
| 4 | Nitric oxide functions as a signal in plant disease resistance 显示文摘 | Delledone M Xia Y Dixon R A | 1998 | Nature1998，394，： | 1 |
| 5 | The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds 显示文摘 | Toth E A Worby C Dixon J E | 2000 | J Mol Biol2000，301，： | 1 |
| 6 | Data fusion for defect characterization using a dual probe system显示文摘 | EDWARDS R S SOPHIAN A DIXON S | 2008 | Sensors and Actuators A:Physical2008，144，1： | 1 |
| 7 | Data Fusion for Defect Characteristic Using a Dual Probe System 显示文摘 | Edwards R S Sophian A Dixon S | 2008 | Sensors and Actuators2008，144，2： | 1 |
| 8 | H2O2 from the oxidative burst orchestrates the plant hypersensitive disease resistance reponse显示文摘 | LEVINE A TENHAKEN R DIXON R | 1994 | Cell1994，79，： | 1 |
| 9 | Psychopathology in female juvenile offenders显示文摘 | Dixon A Howie P Starling J | 2004 | J Child Psychol Psychiatry2004，45，6： | 1 |
| 10 | Update on family psychoeducation for schizophrenia显示文摘 | Dixon L Adams C Lucksted A | 2000 | Schizoph Bull2000，26，11： | 1 |
| 11 | R-Spondin family members regulate the Wnt pathway by a common mechanism显示文摘 | Kim K A Wagle M Tran K Zhan X Dixon M A Liu S | 2008 | Mol Biol Cell2008，19，： | 1 |
| 12 | The role ofthe dissolution of silicic acid powders in aluminosilicatesynthesis mixtures in the crystallization of largemordenite crystals显示文摘 | WARZYWODA J DIXON A G SUIB S L | 1996 | Zeolites1996，16，23： | 1 |
| 13 | Diagenesis and preservation of porosity in Norphlet Formation (Upper Jurassic), southern Alabama显示文摘 | DIXON S A SUMMERS D M SURDAM R C | 1989 | Am Assoc Pet Geol Bull1989，73，： | 1 |
| 14 | Oxidation of biological substrates by chromium(Ⅵ) part1 mechanism of the oxidation of L-Ascorbic acid in aqueous solution显示文摘 | DIXON D A SADLER N P DASGUPTU T P | 1993 | J Chem Soc Dolton Trans1993，，23： | 1 |
| 15 | Proanthocyanidins - a final frontier in flavonoid resarch显示文摘 | DIXON R A DE-YU XIE SHARMA S B | 2005 | New Phytol2005，165，： | 1 |
| 16 | Ecopreneurship- A new approach to managing the triple boltom line显示文摘 | Dixon S E and Clifford A | 2007 | Journal of Organiza- tional Change Management2007，20，3： | 1 |
| 17 | Carbon pools and flux of global forest ecosystems 显示文摘 | Dixon R K Brown S Houghton R A | 1994 | Science1994，263，： | 1 |
| 18 | Carbon pools and flux of global forest ecosystems显示文摘 | Dixon R K Brown S Houghton R A | 1994 | Science1994，262，： | 1 |
| 19 | The oxidative busrt in Plant disease re- sistance 显示文摘 | Lamb C Dixon R A | 1997 | Annual Review of Plant Physiology and Plant Mo- lecular Biology1997，48，： | 1 |
| 20 | Current control strategy for brushless DC motors based on a common DC signal显示文摘 | Juan W Dixon Ivan A Leal | 2009 | IEEE Transaction on Power Electronics2009，17，2： | 1 |
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