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| 1 | Upper-gastrointestinal bleeding secondary to peptic ulcer disease:Incidence and outcomes显示文摘AIM:To evaluate the incidence,surgery,mortality,and readmission of upper gastrointestinal bleeding(UGIB)secondary to peptic ulcer disease(PUD).METHODS:Administrative databases identified all hospitalizations for UGIB secondary to PUD in Alberta,Canada from 2004 to 2010(n=7079)using the International Classification of Diseases Codes(ICD-10).A subset of the data was validated using endoscopy reports.Positive predictive value and sensitivity with 95%confidence intervals(CI)were calculated.Incidence of UGIB secondary to PUD was calculated.Logistic regression was used to evaluate surgery,in-hospital mortality,and 30-d readmission to hospital with recurrent UGIB secondary to PUD.Co-variants accounted for in our logistic regression model included:age,sex,area of residence(i.e.,urban vs rural),number of Charlson comorbidities,presence of perforated PUD,undergoing upper endoscopy,year of admission,and interventional radiological attempt at controlling bleeding.A subgroup analysis(n=6356)compared outcomes of patients with gastric ulcers to those with duodenal ulcers.Adjusted estimates are presented as odds ratios(OR)with95%CI.RESULTS:The positive predictive value and sensitivity of ICD-10 coding for UGIB secondary to PUD were85.2%(95%CI:80.2%-90.2%)and 77.1%(95%CI:69.1%-85.2%),respectively.The annual incidence between 2004 and 2010 ranged from 35.4 to 41.2 per100000.Overall risk of surgery,in-hospital mortality,and 30-d readmission to hospital for UGIB secondary to PUD were 4.3%,8.5%,and 4.7%,respectively.Interventional radiology to control bleeding was performed in 0.6%of patients and 76%of these patients avoided surgical intervention.Thirty-day readmission significantly increased from 3.1%in 2004 to 5.2%in 2010(OR=1.07;95%CI:1.01-1.14).Rural residents(OR rural vs urban:2.35;95%CI:1.83-3.01)and older individuals(OR≥65 vs<65:1.57;95%CI:1.21-2.04)were at higher odds of being readmitted to hospital.Patients with duodenal ulcers had higher odds of dying(OR=1.27;95%CI:1.05-1.53),requiring surgery(OR=1.73;95%CI:1.34-2.23),and being readmitted to hospital(OR=1.54;95%CI:1.19-1.99)when compared to gastric ulcers.CONCLUSION:UGIB secondary to PUD,particularly duodenal ulcers,was associated with significant morbidity and mortality.Early readmissions increased over time and occurred more commonly in rural areas. | Samuel Quan Alexandra Frolkis Kaylee Milne Natalie Molodecky Hong Yang Elijah Dixon Chad G Ball Robert P Myers Subrata Ghosh Robert Hilsden Sander Veldhuyzen van Zanten Gilaad G Kaplan | 2014 | World Journal of Gastroenterology2014，20，46： | 21 |
| 2 | Respose of ectomycorrhizal Pinus banksiana and Picea glauca to heavy metals in soil显示文摘 | Dixon P K Bushena C A | 1988 | Plant and Soil1988，105，1： | 2 |
| 3 | Psychopathology in female juvenile offenders显示文摘 | Dixon A Howie P Starling J | 2004 | J Child Psychol Psychiatry2004，45，6： | 1 |
| 4 | Assessment of commercial test kits for identification of spring viremia of carp virus 显示文摘 | Dixon P F Longshaw C B | 2005 | Dis Aquatic Org2005，67，： | 1 |
| 5 | Oxidation of biological substrates by chromium(Ⅵ) part1 mechanism of the oxidation of L-Ascorbic acid in aqueous solution显示文摘 | DIXON D A SADLER N P DASGUPTU T P | 1993 | J Chem Soc Dolton Trans1993，，23： | 1 |
| 6 | Gastric dysplasia : the padova international classification 显示文摘 | RUGGE M CORREA P DIXON MF | 2000 | Am J Surg Pathol2000，24，2： | 1 |
| 7 | The Madigan prostatectomy 显示文摘 | Dixon A R Lord P H Madigan M R | 1990 | J Urol1990，144，： | 1 |
| 8 | Planting date effects on winter triticale grain yield and yield components显示文摘 | Schwarte A J Gibson L R Karlen D L Dixon P M Liebman M Jannink J | 2006 | Crop Science2006，46，： | 1 |
| 9 | The effect of write-beam wavelength on the grating formation in Eu-doped alkali silicate glasses 显示文摘 | HAMAD A Y WICKSTED J P DIXON G S | 1999 | Opt Mater1999，12，： | 1 |
| 10 | Integration of logic functions and sequential operation of gates at the molecu- lar-scale显示文摘 | de Silva A P Dixon I M Gunaratne H Q N | 1999 | J Am Chem Soc1999，121，6： | 1 |
| 11 | Gastric mucosal atrophy:interobserver consistency using new criteria for classification and grading显示文摘 | Rugge M Correa P Dixon MF | | 0，，： | 1 |
| 12 | The phenylpropanoid pathway and plant defence-agenomics perspective 显示文摘 | DIXON R A ACHNINE L KOTA P | 2002 | Molecular Plant Pathology2002，3，5： | 1 |
| 13 | Extracellular nucieotides stimulate proliferation in MCF7 breast cancer cells via P2 purinoceptors显示文摘 | Dixon C J Bowler W B Fleetwood P Ginty A F Gallagber J A Carron J A | 1997 | Br J Cane er1997，75，： | 1 |
| 14 | Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1 显示文摘 | Whitby R J Dixon S Maloney P R | 2006 | J Med Chem2006，49，： | 1 |
| 15 | The phenylpropanoid pathway and plant defense a genomic perspective 显示文摘 | Dixon R A Achiogyne L Kota P | 2002 | Physiological and Molecular Plant Pathology2002，3，： | 1 |
| 16 | Involved-field ra diotherapy alone for early stage non-small cell lung cancer显示文摘 | Mackillop WJ Dixon P | 2000 | Int J Radiat Oncol Biol Phys2000，48，： | 1 |
| 17 | Meas urement of human pancreatic perfusion using dynamic computed tomography with perfusion imaging显示文摘 | MILES K A HAYBALL M P DIXON A K | 1995 | Radiol1995，68，： | 1 |
| 18 | Bari-atric surgery: an IDF statement for obese Type 2 diabetes 显示文摘 | Dixon JB Zimmet P Alberti KG | 2011 | Diabet Med2011，28，6： | 1 |
| 19 | An extended adaptive Kalman filter for real-time state estimation of vehicle handling dynamics 显示文摘 | Best M GordonT Dixon P | 2000 | Vehi- cle System Dynamics2000，34，1： | 1 |
| 20 | Gastric mucosalatrophy: interobserver consistency using new criteria forclassification and grading 显示文摘 | RUGGE M CORREA P DIXON M F | 2002 | Aliment Pharmacol Ther2002，16，7： | 1 |
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