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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | Mimicking unfolding motion of a beetle hind wing显示文摘This paper presents an experimental research aiming to realize an artificial hind wing that can mimic the wing unfolding motion of Allomyrina dichotoma, an insect in coleopteran order. Based on the understanding of working principles of beetle wing folding/unfolding mechanisms, the hind wing unfolding motion is mimicked by a combination of creative ideas and state-of-art artificial muscle actuator. In this work, we devise two types of artificial wings and the successfully demonstrate that they can be unfolded by actuation of shape memory alloy wires to provide actuation force at the wing base and along the leading edge vein. The folding/unfolding mechanisms may provide an insight for portable nano/micro air vehicles with morphing wings. | MUHAMMAD Azhar PARK Hoon C HWANG Do Y BYUN Doyoung GOO Nam S | 2009 | Chinese Science Bulletin2009，54，14： | 3 |
| 3 | Skin color detection through estimation and conversion of illuminant color under various illuminations 显示文摘 | Do H C You J Y Chien S | 2007 | IEEE Transactions on Consumer Electronics2007，53，3： | 1 |
| 4 | Isolation and characterization of a cDNA encoding chalcone synthase homolog from Phalaenopsis显示文摘 | Hsu W S Do Y Y Huang P L | 1997 | Plant Physiol1997，113，： | 1 |
| 5 | Tumor necrosis factor α-induced interleukin-32 is positively regulated via the Syk/protein kinase Cδ/JNK pathway in rheumatoid synovial fibroblasts显示文摘 | Mun S H Kim J W Nah S S Ko N Y Lee J H Kim J D Kim do K Kim H S Choi J D Kim S H Lee C K Park S H Kim B K Kim H S Kim Y M and Choi W S | | 0，，03： | 1 |
| 6 | The use of biodegradable PLGA nanoparticles to mediate SOX9 gene delivery in human mesenchymal stem cells(hMSCs)and in-duce chondrogenesis显示文摘 | Kim J H Park J S Yang H N Woo D G Jeon S Y Do H J | 2011 | Biomaterials2011，32，： | 1 |
| 7 | Intrinsically Microporous Soluble Polyimides Incorporating Troger’s Base for Membrane Gas Separation显示文摘 | Zhuang Y Seong J G Do Y S | 2014 | Macromolecules2014，47，10： | 1 |
| 8 | Correlation of human olfactory responses to airborne concentrations of malodorous volatile organic compounds emitted from swine effluent显示文摘 | Zahn J A Dispiroto A A Do Y S | 2001 | J Environ Qual2001，30，： | 1 |
| 9 | Structural effects of n-aromatic acyl-aminoacid conjugates on their deconjugation in the cecal contentsof rats: implication in design of a colon-specific prodrugwith controlled conversion rate at the target site 显示文摘 | Kong H Kim H Do H Lee Y Hong S Yoon J H JungY Kim Y M | 2011 | Bio pharmaceutics Drug Disposition2011，32，6： | 1 |
| 10 | Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats 显示文摘 | KWON DO Y JUNG Y S KIM S J | 2009 | J Nutr2009，139，1： | 1 |
| 11 | EUC- guided transural cholecystostomy as rescue manage- ment for acute cholecystitis in elderly or high-risk pa- tients: a prospective feasibility study 显示文摘 | LEE S S PARK DO H HWANG C Y | 2007 | Gastrointest Endos2007，66，： | 1 |
| 12 | Risk factors for operativecomplications in elderly patients during laparoscopya -ssisted gastrectomy显示文摘 | Hwang S H Park do J Jee Y S | 2012 | JAm Coll Surg2012，208，2： | 1 |
| 13 | Endovascular treatment com- bined with emboloscleorotherapy for pelvic arteriovenous malfor- mations显示文摘 | Do Y S Kim Y W Park K H | 2012 | J Vasc Surg2012，55，2： | 1 |
| 14 | Early on-treatment predictions of clinical outcomes using alpha-fetoprotein and des-gamma-carboxy prothrombin responses in patients with advanced hepatocellular carcinoma 显示文摘 | Lee M I-I Kim S U Kim do Y | 2011 | J Gastroen- terol Hepatol2011，27，2： | 1 |
| 15 | Salivary alpha-amylase and cortisol re- sponsiveness following electrical stimulation stress in panic disorder patients 显示文摘 | Tanaka Y Ishitobi Y Maruyama Y Kawano A An- do T Imanaga J Okamoto S Kanehisa H Higuma H Ninomiya T Tsuru J Hanada H Isogawa K Akiyoshi J | 2012 | NeurosciRes2012，73，2： | 1 |
| 16 | Identification of IL7RA risk alleles for rapid progression during HIV-1 infec- tion: a comprehensive study in the GRIV cohort 显示文摘 | Limou S Melica G Coulonges C Lelivre JD Do H McGinn S Gut IG L6vy Y Zagury JF | 2012 | Curr HIV Res2012，10，2： | 1 |
| 17 | Identification and chromosomal organization of two rye genome-specific RAPD products useful as introgression markers in wheat显示文摘 | KO J M DO G S SUH D Y SEO B B SHIN D C MOON H P | 2002 | Genome2002，45，1： | 1 |
| 18 | Non-invasive assessment of changes in liver fibrosis via liver stiffness measurement in patients with chronic hepatitis B : impact of antiviral treatment on fibrosis regression显示文摘 | Kim S U Park J Y Kim do Y | 2010 | Hepatol Int2010，4，4： | 1 |
| 19 | Effect of Metal Oxides on the Reactivity of Persulfate/Fe ( II ) in the Remediation of Diesel-contaminated Soil and Sand 显示文摘 | S H Do Y J Kwon S H Kong | 2010 | Journal of Hazardous Materials2010，182，13： | 1 |
| 20 | Angiotensin has multiple profibrotic effects in human cardiac fibroblasts显示文摘 | Kawano H Do Y S Kawano Y | 2000 | Circulation2000，01，10： | 1 |
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