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| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 3 | Anaerobic ammonium oxi- dation (anammox) in the marine environment 显示文摘 | Dalsgaard T Thamdrup B Donald E C | 2005 | Research in Mi- crobiology2005，156，4： | 1 |
| 4 | Paleoshoreline evidence for postglacial tilting in Southern Manitoba显示文摘 | Gary E T Donald R C Bruce G B | 1998 | Journal of Paleolin- nology1998，19，： | 1 |
| 5 | The Evolution o fan Aerospace Material: Influence of Design, Manufacturing and In-service Performance 显示文摘 | MILLERALAN G LOVELL DONALD T SEFERIS JAMES C | 1994 | Composites Structure1994，27，12： | 1 |
| 6 | The Influence of Top Management Team Heterogeneity on Firms' Competitive Moves显示文摘 | Hambrick Donald C Seung Cho T Chen Ming-Jer | 1996 | AdministrativeScience Quarterly1996，，： | 1 |
| 7 | Development and evaluation of consensus-based sediment quality guidelines for freshwater ecosystems显示文摘 | Mac Donald D D Ingersoll C G Berger T A | 2000 | Archives of\sEnvironmental Contamination and Toxicology2000，39，1： | 1 |
| 8 | Bandwidth Characterization in the Mieropositioning of Ionic Polymer Actuators 显示文摘 | Kothfra C Donald T L | 2005 | Journal of Intelligent Material Systems and Structures2005，16，1： | 1 |
| 9 | CY angiography with whole brain perfused blood volume imaging: added clinical value in the assessment of acute stroke显示文摘 | Ezzeddine M A Lev M H Mc Donald C T | 2002 | Stroke2002，33，2： | 1 |
| 10 | The effects of Allopuninol and superoxide Dismutase in a Rat model of skin flap Necrosis显示文摘 | Alan T Donald A B Charles W C | 1989 | Arch Otolaryngol Head Neclsurg1989，115，： | 1 |
| 11 | Anaerobic ammonium oxidation (anammox) in the marine environment显示文摘 | DALSGAARD T THAMDRUP B DONALD E C | 2005 | Research in Microbiology2005，156，： | 1 |
| 12 | Organisation and origin of a B chromosome centromeric sequence from Brachycome dichromosomatica显示文摘 | Donald T M Franks T K | 1995 | C h romosoma,1995，103，： | 1 |
| 13 | Ingestion of Bacterially Expressed dsRNAs Can Produce Specific and Potent Genetic Interference in Caenorhabditis Elegans显示文摘 | Lisa T Donald L C Andrew F | 2001 | Gene2001，263，： | 1 |
| 14 | Ribosomal RNA geenes and th e B chromosome of Brachycome dichromosomatica显示文摘 | Leach C R Clough A Timmis J N | 1995 | Heredity1995，74，： | 1 |
| 15 | Shaping customer satisfaction through self-awareness cues显示文摘 | Pham M T Goukens C Donald R Lehmann | | 0，，10： | 1 |
| 16 | Development and evaluation of consensus-based sediment quality guidelines for freshwater ecosystems显示文摘 | Mac Donald D D Ingersoll C Berger T | 2000 | Arch Environ Contam Toxicol2000，39，1： | 1 |
| 17 | Impact of Delayed Transfer of Critically Ill Patients from the Emergency Department to the Intensive Care Unit显示文摘 | Donald B C Stephen T Antonionsh L | 2007 | Crit Care Med2007，35，6： | 1 |
| 18 | Regulation of CCAAT/enhancer binding protein, interleukin-6, interleukin-6 receptor , and gp130 expression during myocardial ischonfia/reperfusion显示文摘 | Bysani C Donald H James T | 1999 | Circulation1999，99，： | 1 |
| 19 | Inhibition of Plasmodium clagy gene function by antisense RNA显示文摘 | Donald G J Deborah C H Elizaberh A T | 2000 | Mol Bioehem Parasitol2000，，110： | 1 |
| 20 | Impact of anthropogenic sources and sinks on carbonyl sulfide in the North Pacific troposphere显示文摘 | Donald C T Bandy A R Byron W B | 1996 | J Geophs Res1996，101，： | 1 |
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